ID A0A0D9RVW3_CHLSB Unreviewed; 2624 AA.
AC A0A0D9RVW3;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Telomerase associated protein 1 {ECO:0000313|Ensembl:ENSCSAP00000012752.1};
GN Name=TEP1 {ECO:0000313|Ensembl:ENSCSAP00000012752.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000012752.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000012752.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000012752.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AQIB01128678; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01128679; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR STRING; 60711.ENSCSAP00000012752; -.
DR Ensembl; ENSCSAT00000014791.1; ENSCSAP00000012752.1; ENSCSAG00000016766.1.
DR eggNOG; KOG3602; Eukaryota.
DR eggNOG; KOG4155; Eukaryota.
DR GeneTree; ENSGT00940000161338; -.
DR OMA; WQILPKG; -.
DR Proteomes; UP000029965; Chromosome 29.
DR Bgee; ENSCSAG00000016766; Expressed in adrenal cortex and 7 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0016363; C:nuclear matrix; IEA:Ensembl.
DR GO; GO:0005697; C:telomerase holoenzyme complex; IEA:Ensembl.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0002039; F:p53 binding; IEA:Ensembl.
DR GO; GO:0003720; F:telomerase activity; IEA:Ensembl.
DR GO; GO:0070034; F:telomerase RNA binding; IEA:Ensembl.
DR GO; GO:0000722; P:telomere maintenance via recombination; IEA:Ensembl.
DR CDD; cd00200; WD40; 2.
DR Gene3D; 1.25.40.370; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 6.
DR InterPro; IPR025139; DUF4062.
DR InterPro; IPR045804; DUF5920.
DR InterPro; IPR007111; NACHT_NTPase.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008850; TEP1_N.
DR InterPro; IPR008858; TROVE_dom.
DR InterPro; IPR037214; TROVE_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR44791:SF1; TELOMERASE PROTEIN COMPONENT 1; 1.
DR PANTHER; PTHR44791; TELOMERASE PROTEIN COMPONENT 1 TEP1; 1.
DR Pfam; PF13271; DUF4062; 1.
DR Pfam; PF19334; DUF5920; 1.
DR Pfam; PF05729; NACHT; 1.
DR Pfam; PF05386; TEP1_N; 4.
DR Pfam; PF05731; TROVE; 1.
DR Pfam; PF00400; WD40; 7.
DR SMART; SM00320; WD40; 17.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF140864; TROVE domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 3.
DR PROSITE; PS50837; NACHT; 1.
DR PROSITE; PS51226; TEP1_N; 4.
DR PROSITE; PS50988; TROVE; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 6.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW WD repeat {ECO:0000256|PROSITE-ProRule:PRU00221}.
FT DOMAIN 224..677
FT /note="TROVE"
FT /evidence="ECO:0000259|PROSITE:PS50988"
FT DOMAIN 1163..1431
FT /note="NACHT"
FT /evidence="ECO:0000259|PROSITE:PS50837"
FT REPEAT 1883..1915
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2060..2101
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2106..2146
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2147..2177
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2237..2270
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2548..2578
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REGION 384..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2512..2550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2624 AA; 290416 MW; 5EA757ED311D34DA CRC64;
MEKPHGHVSA HPDILSLENR CLAMLPHLQP MEKLHQHISA HSDILSLKNQ CLATLPDLKT
VEKPHGYVSV HPDILSLENR CLATLSDLKT MEKPHGHVSA HPDILSLENR CLATLPSLKS
TVSASRFFQS LQISHMTQAD LYCVNNSNCL LSEPPSWRAQ HFSKGLDLST CPIALKSVSA
TGTVQEATLG RWFDSEEKKG AEAQMPSYSL SLGEEEEEVE DLAVKLTSGD SESHIEPTDQ
VLQEKKMALL SLLCSTLVSE VNMKDASDPT LTAIFENCRE LAPLEPEFIL KASLYARQQL
NVRNVANKIL AIAAFLPACR PHLRRYFCAI VQLPSDWIQV AELYQSLAEG DENKLVPLPS
CLRAAMTDKF AQFDEYQLAK YNPRKHRAKR HPRRPPRSPR MEPPFSRRPF PRYMVFLRDE
QKKFEKAYDT VSEKKNPPRF TLKKLVQRLH IHEPAQHVQA LLGYRYPSNL QLFSRSRLPG
PWDSSRAGKR MKLSRPETWE RELSLRGNKA SVWEELIENG KLPFMAMLRN LCNLLRVGIS
ARHHELILQR LQHAKSVIHS RQFPFRFLNA YDSIDALEAQ LRNQALPFPS NTTLMRRILT
RSDKNRPRRR FLCHLSCQQL RTVMRVPVMY EKLKREKLRV HKARQWKYDG EMLNRYRQAL
ETAVNLSVKH SLPLLPGRTI LVYLTDANAD KLCPKSNPQG PPLNYALLLI GMMITRAEQV
DVVLCGGDTL KTAVLKAEEG ILKTAIRLQA QVQEFDENGE WSLNTFGKYL LSLAGQRVPV
DRVILFGQSM DEGMINVAKQ LYWQHVNSKC LFVGIVLRRV QYLSPDLNPN DVTLSGCTDG
ILKFIAEHGA SHLLEHVGQM DKIFKIPPPP GKTGVQSLRP LEEDTPSPLA PISQQGWRSI
RLFISSTFRD MHGERDLLLR SVLPALQARA APHRISLHGI DLRWGVTEEE TRRNRQLEVC
LGEVENAQLF VGILGSRYGY IPPSYNLPDH PHFHWAQQYP SGRSVTEMEV MQFLNRSQRL
QPSAQALIYF RDSSFLSSVP DAWKSDFVSE SEEAACRISE LKSCLSRQKG ITCRRYPCEW
GGVAAGRPYV GGLEEFGQLV LQDVWNTIQK LYLQPGALLE QPVSIPDDDL VQATFQQLQK
PPSTARPRLL QDTVQQLMLH HGRLSLVTGQ SGQGKTAFLA SLVSALLAPD GAKVAPLVFF
HFSGARPDQG LALTLLRRLC TYLRGQLKEP GALPNTYRSL VWELQQRLLP KSAESLHPGQ
MLVLIIDGAD RLVDQNGQLI SDWIPKKLPR CVHLVLSVSR DAGLGETLEQ SQGAHVVALG
PLEASARARL VREELALYGK RLEESPFNNQ MRLLLVKRES GRPLYLRLVT DHLRLFTLYE
QVSERLRTLP ATVPLLLQHI LSTLEQEHGP DVLPQALTTL EVTRSGLTVD QLHGVLSVWR
TLPKGTKSWE EAVAAGNSGD PYPMGPFAYL VQSLRSLLGE GPLERPGARL CLPDGPLRTA
AKRRYGKRPG QEDTAHILIA AQLWKTCDAD ASGTFRSCPP EALVDLPYHL LQSGNWGLLS
KFLTNIHVVA AHLELGLVSR LLETHALYAS SVPKEEQKLP EADVAVFRTF LRQQASILSQ
YPQLLPQQAA NQPLDSPVCQ QAPLLSQRWH LQHTLRWLNK PQTMKNQQSS SLSLAVSSSP
TAVAFSTNGQ RAAVGTANGT VYLLDLRTWQ EEKSLVSGCD GISACLFLSN DTLFLTAFDG
LLELWDLQHG CRDRVLQTKA HQYQITGCCL SPDRRLLATV CLGGCLKLWD TVRGQLAFQH
TYPKPLNCVA FHPEGQVIAT GSWAGSISFF QVDGLKVTKD LGAPGASVRT LAFNVPGGVV
AVGRLDSMVE LWAWREGARL AAFPAHHGFV AAALFLHASC QLLTAGEDGK VQVWSGSLGR
PRGHLGSLPL SPALSVALSP DGDRVAVGYR ADGIRIYKIS SGSQGAQGQA LDVAVSALAW
LSPKVLVSGA EDGSLQGWAL KECSLQSLWL LSRFQKPVLG LATSQELLAS ASEDFTVRLW
PRQLLTLPHK AEDFPGGTEL RGHEGPVSCC SFSTDGGSLA TGGRDRSLLC WDVRTPKAPI
LIHSFPACHR DWVTGCAWTK DNLLISCSSD GSVGLWDPES GQRLGQFLGH QSAVSAVAAV
EDHVVSVGRD GTLKVWDHQG VELTSIPAHS GPISHCAAAM EPRAAGQPGS ELLVVTIGLD
GATRLWHPLL VSQTHTFLGH SGPVCAAAVS ETSGLLLTAS EDGSVRLWQV PKEADDTCIP
RSSAAITAMA WAPDGSMAVS GNQAGELILW QEAKAVATAQ APGHIGALIW SSARTFFVLS
ADEKISEWQV KLRKGSAPGN FSLHLNRILR EDLGVLTSLG WAPDGHCLIL AKADLKLLCM
KPGGAPSEIW SSYTENPMIL STHKEYGVFV LQPKDPGVLS FLRQKESGEF EERLNFDINL
ENPSRTLISI TQAKPESESS FLCASSDGML WNLAKCSPEG EWTTGNIWQK KANIPETQTP
GADPSTCRES DAGMDSEPTS QLKTRQRRKI HSGSVTALHV LPELLVTASK DRDVKLWERP
SMQLLGLFRC EGSVSCLEPW LGTNSTLQLA VGDVQGNVYF LSWE
//
