ID A0A0D9RWI8_CHLSB Unreviewed; 907 AA.
AC A0A0D9RWI8;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Klotho beta {ECO:0000313|Ensembl:ENSCSAP00000012977.1};
GN Name=KLB {ECO:0000313|Ensembl:ENSCSAP00000012977.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000012977.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000012977.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000012977.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AQIB01114273; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01114274; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01114275; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01114276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9RWI8; -.
DR STRING; 60711.ENSCSAP00000012977; -.
DR Ensembl; ENSCSAT00000015025.1; ENSCSAP00000012977.1; ENSCSAG00000016930.1.
DR eggNOG; KOG0626; Eukaryota.
DR GeneTree; ENSGT00940000157489; -.
DR OMA; ARMKVTH; -.
DR Proteomes; UP000029965; Chromosome 27.
DR Bgee; ENSCSAG00000016930; Expressed in liver.
DR GO; GO:0017134; F:fibroblast growth factor binding; IEA:Ensembl.
DR GO; GO:0005104; F:fibroblast growth factor receptor binding; IEA:Ensembl.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0090080; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway; IEA:Ensembl.
DR Gene3D; 3.20.20.80; Glycosidases; 2.
DR InterPro; IPR001360; Glyco_hydro_1.
DR InterPro; IPR017853; Glycoside_hydrolase_SF.
DR PANTHER; PTHR10353:SF68; BETA-KLOTHO; 1.
DR PANTHER; PTHR10353; GLYCOSYL HYDROLASE; 1.
DR Pfam; PF00232; Glyco_hydro_1; 3.
DR PRINTS; PR00131; GLHYDRLASE1.
DR SUPFAM; SSF51445; (Trans)glycosidases; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..907
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002345978"
FT REGION 888..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 907 AA; 103623 MW; B76451BF6982669B CRC64;
MSNGGLQRSV ILSALILLRA VTGFSGDGRA IWSKNPNFTP VNESQLFLYD TFPKNFFWGV
GTGALQVEGS WKKDGKGPSI WDHFVHTHLK NVSSTNGSSD SYIFLEKDLS ALDFIGVSFY
QFSISWPRLF PDGIVTVANA KGLQYYNTLL DSLVLRNIEP IVTLYHWDLP LALQEKYGGW
KNDTIIDIFN DYATYCFQTF GDRVKYWITI HNPYLVAWHG YGTGMHAPGE KGNLAAVYTV
GHNLIKAHSK VWHNYNTHFR PHQKGWLSIT LGSHWIEPNR SENTMDILKC QQSMVSVLGW
FANPIHGDGD YPEGMKKKLL SILPLFSEAE KNEVRGTADF FAFSFGPNNF KPLNTMAKMG
QNVSLNLREA LNWIKLEYNN PRILIAENGW FTDSHVKTED TTAIYMMKNF LSQVLQAIRL
DEIRVFGYTA WSLLDGFEWQ DAYTIRRGLF YVDFNSKQKE RKPKSSAHYY KQIIRENGFS
LKEATPDVQG QFPCDFSWGV TESVLKPESV ASSPQFSDPY LYLWNATGNR LLHRVEGVRL
KTRPAQCTDF VNIKKQLEML ARMKVTHYRF ALDWASVLPT GNLSAVNRQA LRYYRCVVSE
GLKLGISAMV TLYYPTHAHL GLPEPLLHDG GWLNPLTVEA FQAYAGLCFQ ELGDLVKLWI
TINEPNRLSD IYNRSGNDTY GAAHNLLVAH ALAWRLYDRQ FRPSQRGAVS LSLHADWAEP
ANPYADSHWR AAERFLQFEI AWFAEPLFKT GDYPAAMREY IASKHRRGLS SSALPRLTEA
ERRLLKGTVD FCALNHFTTR FVMHEQLAGS RYDSDRDIQF LQDITRLSSP TRLAVIPWGV
RKLLRWVRRN YGDMDIYITA SGIDDQALED DRLRKYYLEK YLQEVLKGKG GAPSDTGQSE
ISDKNKE
//
