ID A0A0D9RWP1_CHLSB Unreviewed; 1097 AA.
AC A0A0D9RWP1;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=LIF receptor subunit alpha {ECO:0000313|Ensembl:ENSCSAP00000013030.1};
GN Name=LIFR {ECO:0000313|Ensembl:ENSCSAP00000013030.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000013030.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000013030.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000013030.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the type I cytokine receptor family. Type 2
CC subfamily. {ECO:0000256|ARBA:ARBA00008921}.
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DR EMBL; AQIB01112117; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01112118; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007959628.1; XM_007961437.1.
DR RefSeq; XP_007959629.1; XM_007961438.1.
DR RefSeq; XP_007959630.1; XM_007961439.1.
DR AlphaFoldDB; A0A0D9RWP1; -.
DR STRING; 60711.ENSCSAP00000013030; -.
DR Ensembl; ENSCSAT00000015080.1; ENSCSAP00000013030.1; ENSCSAG00000016984.1.
DR GeneID; 103215156; -.
DR CTD; 3977; -.
DR eggNOG; ENOG502QQF6; Eukaryota.
DR GeneTree; ENSGT00940000155776; -.
DR OMA; FFLYGCK; -.
DR OrthoDB; 5347052at2759; -.
DR BioGRID-ORCS; 103215156; 3 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 4.
DR Bgee; ENSCSAG00000016984; Expressed in liver and 6 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0043235; C:receptor complex; IEA:Ensembl.
DR GO; GO:0005127; F:ciliary neurotrophic factor receptor binding; IEA:Ensembl.
DR GO; GO:0019838; F:growth factor binding; IEA:Ensembl.
DR GO; GO:0004923; F:leukemia inhibitory factor receptor activity; IEA:Ensembl.
DR GO; GO:0004924; F:oncostatin-M receptor activity; IEA:Ensembl.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IEA:Ensembl.
DR CDD; cd00063; FN3; 3.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR003529; Hematopoietin_rcpt_Gp130_CS.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR048497; LIF-R-like_Ig-like.
DR InterPro; IPR040817; LIFR_D2.
DR InterPro; IPR040901; LIFR_N.
DR PANTHER; PTHR23036; CYTOKINE RECEPTOR; 1.
DR PANTHER; PTHR23036:SF105; LEUKEMIA INHIBITORY FACTOR RECEPTOR; 1.
DR Pfam; PF00041; fn3; 1.
DR Pfam; PF21177; LIF-R_Ig-like; 1.
DR Pfam; PF17971; LIFR_D2; 1.
DR Pfam; PF18207; LIFR_N; 1.
DR SMART; SM00060; FN3; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR PROSITE; PS50853; FN3; 4.
DR PROSITE; PS01353; HEMATOPO_REC_L_F2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 834..859
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 335..434
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 435..534
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 538..629
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 726..833
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 983..1006
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1066..1097
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1081..1097
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1097 AA; 123817 MW; 209017C077DE9404 CRC64;
MMDIYVCLKR ASWMVDNKRM RTASNFQWLL STFILLYLMS QVNSQKKGAP HDLKCVTNNL
QVWDCYWKAP SGTGRGTDYE VCIENRSHSC YQLEKTNIKI PALSHGGYEI TINSLHDFGS
STSKFTLNEQ NVSLIPDTPE ILNLSADFST SILYLKWNDR GSVFPHHSNV IWEIKILRKE
SMELVKLVTH NTTLNGKDTL HHWSWASDMP LECAIHFVEI RCYIDNLHFS GRKEWSDWSP
VKNISWMPDS QTKVFPQDKV ILVGSDITFC CVSQEKVLSA LIGHTNCPLI HLDGENVAIK
IHNISVSASS GTNVVFTTED NIFGTVIFAG YPPDTPQQLN CETHDLKEIL CSWNPGRATA
LVGPRATSYT LLESFSGKYV RFKRAEAPTN ESYQLFFQML PNQEIYNFTL NAHNPLGRSE
STILVNITEK VYPHTPTSFK VKDINSTAVK LSWHLPGNFA KINFLCQIEI KKSNRVQEQR
NVTIKGVENS SYLVALDKLN PYTVYTFRIR CSTETFWKWS KWSNKKQHLT TEAIPSKGPD
TWREWSSDGK NLIIYWKPLP INEANGKILS YNVSCSSDEE TQSLSEIPDP QHKAEIQLDK
NDYIISVVAK NSVGSSPPSK IASMEIPNDD LKIEQVVGMG KGILLTWHYD PNMTCDYVIK
WCNSSRSEPC LMDWRKVPSN STETVIESDQ FRPGVRYNFF LYGCKNQGYQ LLRSMIGYIE
ELAPTVAPNF TVEDTSADSI LVKWEDIPVE ELRGFLRGYL FYFGKGERDT SKMRVLESGR
SDIKVKNITD ISQKTLRIAD LQGKTSYHLV LRAYTDGGVG PEKSMYVVTK ENSVGLIIAI
LIPVAVAVIV GVVTSILCYR KREWIKETFY PDIPNPENCK ALQFQKSVCE GSSGLKTLEM
NPCTPNNVEV LETRSAFPKI EDTEIISPVA ERPEDRSDAE PENHVVVSYC PPIIEEEIPN
PAADEAGGTA QVIYIDVQSM YQPQAKPEEE QENDPVGGAG YKPQMHLPIN STVEDIAAEE
DLEKTAGYRP QANVNTWNLV SPDSPRSIDS NSEIVSFGSP CSINSRQFLI PPKDEDSPKS
NGGGWSFTNF FQNKPND
//
