ID A0A0D9RWW0_CHLSB Unreviewed; 1220 AA.
AC A0A0D9RWW0;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE SubName: Full=Adhesion G protein-coupled receptor G6 {ECO:0000313|Ensembl:ENSCSAP00000013099.1};
GN Name=ADGRG6 {ECO:0000313|Ensembl:ENSCSAP00000013099.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000013099.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000013099.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000013099.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily.
CC {ECO:0000256|ARBA:ARBA00007343}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR EMBL; AQIB01064020; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01064021; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01064022; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01064023; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01064024; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01064025; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01064026; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01064027; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01064028; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01064029; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008005026.1; XM_008006835.1.
DR AlphaFoldDB; A0A0D9RWW0; -.
DR STRING; 60711.ENSCSAP00000013099; -.
DR Ensembl; ENSCSAT00000015151.1; ENSCSAP00000013099.1; ENSCSAG00000017057.1.
DR GeneID; 103240264; -.
DR CTD; 57211; -.
DR eggNOG; KOG3714; Eukaryota.
DR eggNOG; KOG4193; Eukaryota.
DR GeneTree; ENSGT00940000155621; -.
DR OMA; AVHHPIC; -.
DR OrthoDB; 3026989at2759; -.
DR BioGRID-ORCS; 103240264; 1 hit in 8 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 13.
DR Bgee; ENSCSAG00000017057; Expressed in liver and 5 other cell types or tissues.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:Ensembl.
DR GO; GO:0019933; P:cAMP-mediated signaling; IEA:Ensembl.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0042552; P:myelination; IEA:Ensembl.
DR GO; GO:0014037; P:Schwann cell differentiation; IEA:Ensembl.
DR CDD; cd00041; CUB; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.60.220.50; -; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001759; Pentraxin-related.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR12011; ADHESION G-PROTEIN COUPLED RECEPTOR; 1.
DR PANTHER; PTHR12011:SF290; ADHESION G-PROTEIN COUPLED RECEPTOR G6; 1.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF00431; CUB; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00354; Pentaxin; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00042; CUB; 1.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00159; PTX; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 1.
DR PROSITE; PS01180; CUB; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00059};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023040};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..37
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 38..1220
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002345821"
FT TRANSMEM 865..888
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 900..921
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 927..949
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 969..990
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1018..1048
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1069..1088
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1094..1116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 41..149
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 863..1117
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 1155..1175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 94..111
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
SQ SEQUENCE 1220 AA; 136604 MW; 60496D1FCB72E18E CRC64;
MMFRSDRMWS CHWKWKPSPL LFLFALYIMC VPHSVWGCAN CRVVLSNPSG TFTSPCYPND
YPNSQACMWT LRAPTGYIIQ ITFNDFDIEE APNCIYDSLS LDNGESQTKF CGATAKGLSF
NSSANEMHVS FSSDFSIQKK GFNASYIRVA VSLRNQKVIL PQTSDAYQVS VAKSVSIPEL
SAFTLCFEAT KVGHEDNDWT AFSYSNASFT QLLSFGKAKS GYFLSISDSK CLLNNALPVK
EKEDIFAESF EQLCLVWNNS LGSIGVNFKR NYETVPCDST ISKVIPGNGK LLLGSNQNEI
VSLKGDIYNF RLWNFTMNAK ILSNLSCNMK GNVVDWQNDF WNIPNLALKA ESNLSCGSYL
IPLPAAELAS CADLGTLCQA TVNSPSTTPP TVTTNMPVTN RIDKQKNDGI IYRISVVIQN
ILRHPEVKVQ SKVAEWLNST FENWNYTVYV INISFHLSGG EDKIKVKRSV ENEPRLVLWA
LLVYNATNNT NLEGKIIQQK LLKNNESLDE GLRLHTVNVR QLGHCLAVEE PKGYYWPSIQ
PSEYVLPCPD KPDFSASRIC YYNATNPSVT YWGPPDISNC SKANDVANQI LDLTADGQNL
TSANITNIVE QVKRIVNKEE NIDITLGSTL MNIFSNILSS SDSDLLESSS EALKTIDELA
FKIDLNSTSH VNITTRNLAL GVSSLLPGTN AISNFSIGLP SNNESYFQMD FESGQVDPLA
SVILPPNLLE NLSQEDSVLV RRAQFTFFNK TGLFQDVGPQ RKTLVSYVMA CSIGNITIQN
LKDPVQIKIK HTRTQEVHHP ICAFWDLNKN KSFGGWNTSG CVAHRDSDAS ETVCLCNHFT
HFGVLMDLPR SASQLDARNT KVLTFISYIG CGISAIFSAA TLLTYVAFEK LRRDYPSKIL
MNLSAALLFL NLLFLLDGWI TSFNVDGLCI AVAVLLHFFL LATFTWMGLE AIHMYIALVK
VFNTYIRRYI LKFCIIGWGL PALVVSIVLA SRNKNEVYGK ESYGKEKGDE FCWIQDPVIF
YVTCAGYFGV MFFLNIAMFI VVMVQICGRN GKRSNRTLRE EVLRNLRSVV SLTFLLGMTW
GFAFFAWGPL NIPFMYLFSI FNSLQGLFIF IFHCAMKENV QKQWRRHLCC GRFRLADNSD
WSKTATNIIK KSSDNLGKSL SSSSIGSNST YLTSKSKSSS TTYFKRNSHT DNVSYEHSFN
KSGSFRQCFH GQVLVKTGPC
//
