ID A0A0D9RX09_CHLSB Unreviewed; 539 AA.
AC A0A0D9RX09;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Interleukin 18 receptor 1 {ECO:0000313|Ensembl:ENSCSAP00000013148.1};
GN Name=IL18R1 {ECO:0000313|Ensembl:ENSCSAP00000013148.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000013148.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000013148.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000013148.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the interleukin-1 receptor family.
CC {ECO:0000256|ARBA:ARBA00009752}.
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DR EMBL; AQIB01138485; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008006448.1; XM_008008257.1.
DR AlphaFoldDB; A0A0D9RX09; -.
DR STRING; 60711.ENSCSAP00000013148; -.
DR Ensembl; ENSCSAT00000015202.1; ENSCSAP00000013148.1; ENSCSAG00000017115.1.
DR GeneID; 103241155; -.
DR KEGG; csab:103241155; -.
DR CTD; 8809; -.
DR eggNOG; ENOG502QUAC; Eukaryota.
DR GeneTree; ENSGT01090000259985; -.
DR OMA; HFMGRDE; -.
DR OrthoDB; 4322253at2759; -.
DR BioGRID-ORCS; 103241155; 1 hit in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 14.
DR Bgee; ENSCSAG00000017115; Expressed in blood and 3 other cell types or tissues.
DR GO; GO:0045092; C:interleukin-18 receptor complex; IEA:Ensembl.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0042007; F:interleukin-18 binding; IEA:Ensembl.
DR GO; GO:0042008; F:interleukin-18 receptor activity; IEA:Ensembl.
DR GO; GO:0030101; P:natural killer cell activation; IEA:Ensembl.
DR GO; GO:0120163; P:negative regulation of cold-induced thermogenesis; IEA:Ensembl.
DR GO; GO:1901224; P:positive regulation of non-canonical NF-kappaB signal transduction; IEA:Ensembl.
DR GO; GO:2000556; P:positive regulation of T-helper 1 cell cytokine production; IEA:Ensembl.
DR GO; GO:0032729; P:positive regulation of type II interferon production; IEA:Ensembl.
DR GO; GO:0045063; P:T-helper 1 cell differentiation; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR015621; IL-1_rcpt_fam.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR PANTHER; PTHR11890; INTERLEUKIN-1 RECEPTOR FAMILY MEMBER; 1.
DR PANTHER; PTHR11890:SF6; INTERLEUKIN-18 RECEPTOR 1; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR01537; INTRLKN1R1F.
DR SMART; SM00409; IG; 3.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS50104; TIR; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|SAM:Phobius}; NAD {ECO:0000256|ARBA:ARBA00023027};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..539
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002346215"
FT TRANSMEM 330..352
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 7..110
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 219..311
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 372..519
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 539 AA; 62027 MW; 51F04463D8DEA5FD CRC64;
MNCRELPLTL WVLIFVSTAE SCTSRPHITV VEGEPFYLKY CSCSPAHEIE TITKSWYKSS
GSQERVELNP RSSSRIALHG CVLEFWPVEL NDTGSYSFQM ENYTQKWKLN VIRRNKHSCF
TERQVTSKTV EVKKFLQITC ENSYYQTLVN STSLYKNCKK LLENNKNPMI KKNAELEDQG
YYSCVHFLHH NGKLFNITKT FNITIVEDHS NIVPVLLGPK LNHVAVELGK DVRLNCSALL
NEEDVLYWMF GEENGSDPNI HEEKEIRIMT SEGKWHASKV LRIENIGENN LNVLYNCTVA
STGGTDTKSF ILVRKADMAD IPGHVFTRGM IIAVLILVAV VCLVTVCVIY RVDLVLFYRH
LMRRDETLTD GKTYDAFVSY LKECRPENGE EHTFAVEILP RVLEKHFGYK LCIFERDVVP
GGAVVDEIHS LIEKSRRLII VLSKSYMSNE VRYELESGLH EALVERKIKI ILIEFTPVTD
FTFLPQSLKL LKSHRVLKWK ADKSLSYNSR FWKNLLYLMP AKAKPSRDES EVLPVLSES
//