ID A0A0D9RYF9_CHLSB Unreviewed; 466 AA.
AC A0A0D9RYF9;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=Clusterin {ECO:0000256|RuleBase:RU000629};
GN Name=CLUL1 {ECO:0000313|Ensembl:ENSCSAP00000013648.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000013648.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000013648.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000013648.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the clusterin family.
CC {ECO:0000256|ARBA:ARBA00010069, ECO:0000256|RuleBase:RU000629}.
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DR EMBL; AQIB01129190; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01129191; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007972687.1; XM_007974496.1.
DR AlphaFoldDB; A0A0D9RYF9; -.
DR STRING; 60711.ENSCSAP00000013648; -.
DR Ensembl; ENSCSAT00000015717.1; ENSCSAP00000013648.1; ENSCSAG00000017625.1.
DR eggNOG; ENOG502QQ44; Eukaryota.
DR GeneTree; ENSGT00530000063668; -.
DR OMA; YLSEDCP; -.
DR OrthoDB; 5320180at2759; -.
DR BioGRID-ORCS; 103222678; 2 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 18.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR000753; Clusterin-like.
DR InterPro; IPR016015; Clusterin_C.
DR InterPro; IPR016014; Clusterin_N.
DR PANTHER; PTHR10970; CLUSTERIN; 1.
DR PANTHER; PTHR10970:SF2; CLUSTERIN-LIKE PROTEIN 1; 1.
DR Pfam; PF01093; Clusterin; 1.
DR SMART; SM00035; CLa; 1.
DR SMART; SM00030; CLb; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..466
FT /note="Clusterin"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002346440"
FT DOMAIN 26..237
FT /note="Clusterin N-terminal"
FT /evidence="ECO:0000259|SMART:SM00030"
FT DOMAIN 238..460
FT /note="Clusterin C-terminal"
FT /evidence="ECO:0000259|SMART:SM00035"
FT COILED 63..104
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 466 AA; 54217 MW; 51DA853A089805BC CRC64;
MKPPLLVFTV YLLWLKDCHC APTWKDKTAI SENLKSFSEV GEIDTDEEVK KALIGIKQMK
IMMERKEKEH TNLMSTLMKC REEKQEALKL LNEVQEHLEA EERLCQVSLA DSWDECRSCL
ENNCMRIYTT CQPSWSSVKN KIEQFFQKIY QFLFPFHEDN EKDLPISEKL IEEDAQLTQI
EDVFSQLTVD VNSLFDRSFN VFRQMQQEFD QTFQSHFISD TDLTEHYFFP AFSKEPMTKA
DLEQHWDIPN FFQLFCNFSV SIYESVSETI TKTLKAIEDL PKQDKAPDHG GLISKMLPGQ
DRGLCGELEQ NLSRCFKFHE KCQKCQAHLS EDCPGVPALH TELDEAIRLV NVSNQQYSQI
LQMTRKHLED TAYLVEKMRG RFGWVSELAN QTPETEIIFN SIQVVPRIHE GNISKQDETV
MTDLSILPSS NSTLKIPLEE SAESSNFIGY VLANVLQHFK EHFKTW
//
