ID A0A0D9S005_CHLSB Unreviewed; 251 AA.
AC A0A0D9S005;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=VPS37D subunit of ESCRT-I {ECO:0000313|Ensembl:ENSCSAP00000014194.1};
GN Name=VPS37D {ECO:0000313|Ensembl:ENSCSAP00000014194.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000014194.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000014194.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000014194.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Component of the ESCRT-I complex, a regulator of vesicular
CC trafficking process. Required for the sorting of endocytic
CC ubiquitinated cargos into multivesicular bodies. May be involved in
CC cell growth and differentiation. {ECO:0000256|ARBA:ARBA00025010}.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004481}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004481}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004633}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004633}.
CC -!- SIMILARITY: Belongs to the VPS37 family.
CC {ECO:0000256|ARBA:ARBA00007617}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AQIB01139683; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008016535.1; XM_008018344.1.
DR AlphaFoldDB; A0A0D9S005; -.
DR SMR; A0A0D9S005; -.
DR STRING; 60711.ENSCSAP00000014194; -.
DR Ensembl; ENSCSAT00000016274.1; ENSCSAP00000014194.1; ENSCSAG00000018178.1.
DR GeneID; 103246633; -.
DR KEGG; csab:103246633; -.
DR CTD; 155382; -.
DR eggNOG; KOG3270; Eukaryota.
DR GeneTree; ENSGT00950000183012; -.
DR OMA; LQVDREM; -.
DR OrthoDB; 5316621at2759; -.
DR BioGRID-ORCS; 103246633; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 28.
DR Bgee; ENSCSAG00000018178; Expressed in prefrontal cortex and 5 other cell types or tissues.
DR GO; GO:0000813; C:ESCRT I complex; IEA:Ensembl.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0009056; P:catabolic process; IEA:UniProt.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR InterPro; IPR009851; Mod_r.
DR PANTHER; PTHR13678; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37; 1.
DR PANTHER; PTHR13678:SF12; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37D; 1.
DR Pfam; PF07200; Mod_r; 1.
DR PROSITE; PS51314; VPS37_C; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 93..182
FT /note="VPS37 C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51314"
FT REGION 174..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 86..143
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 209..251
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 251 AA; 27730 MW; A07E752409455026 CRC64;
MYRARAARAG PEPGSPGRFG ILSTGQLRDL LQDEPKLDRI VRLSRKFQGL QLEREACLAS
NYALAKENLA LRPRLEMGRA ALAIKYQELR EVAENCADKL QRLEESMHRW SPHCALGWLQ
AELEEAEQEA EEQMEQLLLG EQSLEAFLPA FQRGRALAHL RRTQAEKLQE LLRRRERSAQ
PAPTSAADPP KSFPAAAVLP TGAARGPPAV PRSLPPLDSR PVPPLKGSPG CPLGPAPLLS
PRPSQPEPPH R
//
