ID A0A0D9S358_CHLSB Unreviewed; 207 AA.
AC A0A0D9S358;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=Granulocyte colony-stimulating factor {ECO:0000256|ARBA:ARBA00019452};
GN Name=CSF3 {ECO:0000313|Ensembl:ENSCSAP00000015297.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000015297.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000015297.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000015297.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Granulocyte/macrophage colony-stimulating factors are
CC cytokines that act in hematopoiesis by controlling the production,
CC differentiation, and function of 2 related white cell populations of
CC the blood, the granulocytes and the monocytes-macrophages. This CSF
CC induces granulocytes. {ECO:0000256|ARBA:ARBA00024794}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the IL-6 superfamily.
CC {ECO:0000256|ARBA:ARBA00007432}.
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DR EMBL; AQIB01145439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9S358; -.
DR STRING; 60711.ENSCSAP00000015297; -.
DR Ensembl; ENSCSAT00000000766.1; ENSCSAP00000015297.1; ENSCSAG00000002760.1.
DR eggNOG; ENOG502SCNA; Eukaryota.
DR GeneTree; ENSGT00390000017328; -.
DR OMA; APLEQCH; -.
DR Proteomes; UP000029965; Chromosome 16.
DR Bgee; ENSCSAG00000002760; Expressed in fibroblast and 1 other cell type or tissue.
DR GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR GO; GO:0005130; F:granulocyte colony-stimulating factor receptor binding; IEA:Ensembl.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0038158; P:granulocyte colony-stimulating factor signaling pathway; IEA:Ensembl.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl.
DR GO; GO:0045639; P:positive regulation of myeloid cell differentiation; IEA:Ensembl.
DR GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR Gene3D; 1.20.1250.10; -; 1.
DR InterPro; IPR009079; 4_helix_cytokine-like_core.
DR InterPro; IPR040117; GCSF/MGF.
DR InterPro; IPR030474; IL-6/GCSF/MGF.
DR InterPro; IPR030473; IL6/GCSF/MGF_CS.
DR PANTHER; PTHR10511; GRANULOCYTE COLONY-STIMULATING FACTOR; 1.
DR PANTHER; PTHR10511:SF2; GRANULOCYTE COLONY-STIMULATING FACTOR; 1.
DR Pfam; PF16647; GCSF; 1.
DR PIRSF; PIRSF001935; IL6_MGF_GCSF; 1.
DR PRINTS; PR00433; IL6GCSFMGF.
DR SMART; SM00126; IL6; 1.
DR SUPFAM; SSF47266; 4-helical cytokines; 1.
DR PROSITE; PS00254; INTERLEUKIN_6; 1.
PE 3: Inferred from homology;
KW Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW Disulfide bond {ECO:0000256|PIRSR:PIRSR001935-1};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..30
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 31..207
FT /note="Granulocyte colony-stimulating factor"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002346182"
FT DISULFID 69..75
FT /evidence="ECO:0000256|PIRSR:PIRSR001935-1"
FT DISULFID 97..107
FT /evidence="ECO:0000256|PIRSR:PIRSR001935-1"
SQ SEQUENCE 207 AA; 22537 MW; 75B107F1EE6BD48D CRC64;
MAVPAAQSPM KLMALQLLLW HSTLWTVQEA TPLGPASSLP QSFLLKCLEQ VRKIQGDGAA
LQEKLVSECA TYKLCHPEEL VLLRHSLGIP WAPLSSCPSQ ALQLTGCLSQ LHSGLFLYQG
LLQALEGISP ELGPTLDTLQ LDVADFATTI WQQMEDLGMA PALQPTQGAM PAFTSAFQRR
AGGVLVASHL QRFLELAYRV LRHLAQS
//