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Database: UniProt
Entry: A0A0D9S358_CHLSB
LinkDB: A0A0D9S358_CHLSB
Original site: A0A0D9S358_CHLSB 
ID   A0A0D9S358_CHLSB        Unreviewed;       207 AA.
AC   A0A0D9S358;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   RecName: Full=Granulocyte colony-stimulating factor {ECO:0000256|ARBA:ARBA00019452};
GN   Name=CSF3 {ECO:0000313|Ensembl:ENSCSAP00000015297.1};
OS   Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Chlorocebus.
OX   NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000015297.1, ECO:0000313|Proteomes:UP000029965};
RN   [1] {ECO:0000313|Ensembl:ENSCSAP00000015297.1, ECO:0000313|Proteomes:UP000029965}
RP   NUCLEOTIDE SEQUENCE.
RA   Warren W., Wilson R.K.;
RL   Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSCSAP00000015297.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (JUL-2023) to UniProtKB.
CC   -!- FUNCTION: Granulocyte/macrophage colony-stimulating factors are
CC       cytokines that act in hematopoiesis by controlling the production,
CC       differentiation, and function of 2 related white cell populations of
CC       the blood, the granulocytes and the monocytes-macrophages. This CSF
CC       induces granulocytes. {ECO:0000256|ARBA:ARBA00024794}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the IL-6 superfamily.
CC       {ECO:0000256|ARBA:ARBA00007432}.
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DR   EMBL; AQIB01145439; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A0A0D9S358; -.
DR   STRING; 60711.ENSCSAP00000015297; -.
DR   Ensembl; ENSCSAT00000000766.1; ENSCSAP00000015297.1; ENSCSAG00000002760.1.
DR   eggNOG; ENOG502SCNA; Eukaryota.
DR   GeneTree; ENSGT00390000017328; -.
DR   OMA; APLEQCH; -.
DR   Proteomes; UP000029965; Chromosome 16.
DR   Bgee; ENSCSAG00000002760; Expressed in fibroblast and 1 other cell type or tissue.
DR   GO; GO:0005615; C:extracellular space; IEA:UniProtKB-KW.
DR   GO; GO:0005125; F:cytokine activity; IEA:UniProtKB-KW.
DR   GO; GO:0019899; F:enzyme binding; IEA:Ensembl.
DR   GO; GO:0005130; F:granulocyte colony-stimulating factor receptor binding; IEA:Ensembl.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0038158; P:granulocyte colony-stimulating factor signaling pathway; IEA:Ensembl.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0030838; P:positive regulation of actin filament polymerization; IEA:Ensembl.
DR   GO; GO:0045639; P:positive regulation of myeloid cell differentiation; IEA:Ensembl.
DR   GO; GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Ensembl.
DR   GO; GO:0051897; P:positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   Gene3D; 1.20.1250.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR040117; GCSF/MGF.
DR   InterPro; IPR030474; IL-6/GCSF/MGF.
DR   InterPro; IPR030473; IL6/GCSF/MGF_CS.
DR   PANTHER; PTHR10511; GRANULOCYTE COLONY-STIMULATING FACTOR; 1.
DR   PANTHER; PTHR10511:SF2; GRANULOCYTE COLONY-STIMULATING FACTOR; 1.
DR   Pfam; PF16647; GCSF; 1.
DR   PIRSF; PIRSF001935; IL6_MGF_GCSF; 1.
DR   PRINTS; PR00433; IL6GCSFMGF.
DR   SMART; SM00126; IL6; 1.
DR   SUPFAM; SSF47266; 4-helical cytokines; 1.
DR   PROSITE; PS00254; INTERLEUKIN_6; 1.
PE   3: Inferred from homology;
KW   Cytokine {ECO:0000256|ARBA:ARBA00022514};
KW   Disulfide bond {ECO:0000256|PIRSR:PIRSR001935-1};
KW   Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW   Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           31..207
FT                   /note="Granulocyte colony-stimulating factor"
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5002346182"
FT   DISULFID        69..75
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001935-1"
FT   DISULFID        97..107
FT                   /evidence="ECO:0000256|PIRSR:PIRSR001935-1"
SQ   SEQUENCE   207 AA;  22537 MW;  75B107F1EE6BD48D CRC64;
     MAVPAAQSPM KLMALQLLLW HSTLWTVQEA TPLGPASSLP QSFLLKCLEQ VRKIQGDGAA
     LQEKLVSECA TYKLCHPEEL VLLRHSLGIP WAPLSSCPSQ ALQLTGCLSQ LHSGLFLYQG
     LLQALEGISP ELGPTLDTLQ LDVADFATTI WQQMEDLGMA PALQPTQGAM PAFTSAFQRR
     AGGVLVASHL QRFLELAYRV LRHLAQS
//
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