ID A0A0D9S3A3_CHLSB Unreviewed; 445 AA.
AC A0A0D9S3A3;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=StAR-related lipid transfer protein 3 {ECO:0000256|ARBA:ARBA00020514};
DE AltName: Full=START domain-containing protein 3 {ECO:0000256|ARBA:ARBA00032621};
GN Name=STARD3 {ECO:0000313|Ensembl:ENSCSAP00000015342.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000015342.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000015342.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000015342.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=cholesterol(in) = cholesterol(out); Xref=Rhea:RHEA:39747,
CC ChEBI:CHEBI:16113; Evidence={ECO:0000256|ARBA:ARBA00034049};
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Late endosome membrane
CC {ECO:0000256|ARBA:ARBA00004107}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004107}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the STARD3 family.
CC {ECO:0000256|ARBA:ARBA00010909}.
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DR EMBL; AQIB01145428; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008011050.1; XM_008012859.1.
DR AlphaFoldDB; A0A0D9S3A3; -.
DR STRING; 60711.ENSCSAP00000015342; -.
DR Ensembl; ENSCSAT00000000722.1; ENSCSAP00000015342.1; ENSCSAG00000002705.1.
DR GeneID; 103243537; -.
DR CTD; 10948; -.
DR eggNOG; KOG3845; Eukaryota.
DR GeneTree; ENSGT00940000159051; -.
DR OMA; AWVETWF; -.
DR OrthoDB; 3740290at2759; -.
DR BioGRID-ORCS; 103243537; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 16.
DR Bgee; ENSCSAG00000002705; Expressed in adrenal cortex and 7 other cell types or tissues.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:Ensembl.
DR GO; GO:0140284; C:endoplasmic reticulum-endosome membrane contact site; IEA:Ensembl.
DR GO; GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0015485; F:cholesterol binding; IEA:Ensembl.
DR GO; GO:0120020; F:cholesterol transfer activity; IEA:InterPro.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0030301; P:cholesterol transport; IEA:Ensembl.
DR GO; GO:0006701; P:progesterone biosynthetic process; IEA:Ensembl.
DR GO; GO:0099044; P:vesicle tethering to endoplasmic reticulum; IEA:Ensembl.
DR CDD; cd08906; START_STARD3-like; 1.
DR Gene3D; 3.30.530.20; -; 1.
DR InterPro; IPR019498; MENTAL.
DR InterPro; IPR000799; StAR-like.
DR InterPro; IPR029867; STARD3_MLN64_C.
DR InterPro; IPR023393; START-like_dom_sf.
DR InterPro; IPR002913; START_lipid-bd_dom.
DR PANTHER; PTHR46121:SF2; STAR-RELATED LIPID TRANSFER PROTEIN 3; 1.
DR PANTHER; PTHR46121; STEROIDOGENIC ACUTE REGULATORY PROTEIN-LIKE; 1.
DR Pfam; PF10457; MENTAL; 1.
DR Pfam; PF01852; START; 1.
DR PRINTS; PR00978; STARPROTEIN.
DR SMART; SM00234; START; 1.
DR SUPFAM; SSF55961; Bet v1-like; 1.
DR PROSITE; PS51439; MENTAL; 1.
DR PROSITE; PS50848; START; 1.
PE 3: Inferred from homology;
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Lipid-binding {ECO:0000256|ARBA:ARBA00023121};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 52..70
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 98..116
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 121..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 46..217
FT /note="MENTAL"
FT /evidence="ECO:0000259|PROSITE:PS51439"
FT DOMAIN 248..443
FT /note="START"
FT /evidence="ECO:0000259|PROSITE:PS50848"
SQ SEQUENCE 445 AA; 50243 MW; 04DB1E11A216116D CRC64;
MSKLPGELAR DLECSLPAVA SLGSSLSHSQ SLSSHLLPPP EKRRAISDVR RTFCLFVTFD
LLFISLLWII ELNTNTGIRK NLEQEIIQYN FKTSFFDIFV LAFFRFSGLL LGYAVLRLRH
WWVIAVTTLV SSAFLIVKVI LSELLSKGAF GYLLPIVSFV LAWLETWFLD FKVLPQEAEE
ERWYLAAQAA VAHGPLLFSG ALSEGQFYSP PESFAGSDNE SDEEVAGKKS FSAQEREYIR
QGKEATAVVD QILAQEENWK FEKNNEYGDT VYTIEVPFHG KTFILKTFLP CPAELVYQEV
ILQPERMVLW NKTVTACQIL QRVEDNTLIS YDVSAGAAGG VVSPRDFVNV RRIERRRDRY
LSSGIATAHS AKPPTHKYVR GENGPGGFVV LKSASNPRVC TFVWILNTDL KGRLPRYLIH
QSLAATMFEF AFHLRQRISE LGARA
//
