ID A0A0D9S499_CHLSB Unreviewed; 530 AA.
AC A0A0D9S499;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Chromobox 2 {ECO:0000313|Ensembl:ENSCSAP00000015688.1};
GN Name=CBX2 {ECO:0000313|Ensembl:ENSCSAP00000015688.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000015688.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000015688.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000015688.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; AQIB01145015; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008011347.1; XM_008013156.1.
DR AlphaFoldDB; A0A0D9S499; -.
DR STRING; 60711.ENSCSAP00000015688; -.
DR Ensembl; ENSCSAT00000000368.1; ENSCSAP00000015688.1; ENSCSAG00000002350.1.
DR GeneID; 103243681; -.
DR KEGG; csab:103243681; -.
DR CTD; 84733; -.
DR eggNOG; KOG2748; Eukaryota.
DR GeneTree; ENSGT00940000158816; -.
DR OMA; AHTKEAC; -.
DR OrthoDB; 75895at2759; -.
DR BioGRID-ORCS; 103243681; 0 hits in 16 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 16.
DR Bgee; ENSCSAG00000002350; Expressed in fibroblast and 2 other cell types or tissues.
DR GO; GO:0000791; C:euchromatin; IEA:Ensembl.
DR GO; GO:0000792; C:heterochromatin; IEA:Ensembl.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0035102; C:PRC1 complex; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0035064; F:methylated histone binding; IEA:Ensembl.
DR GO; GO:0045137; P:development of primary sexual characteristics; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR CDD; cd18647; CD_Cbx2; 1.
DR Gene3D; 2.40.50.40; -; 1.
DR InterPro; IPR042796; CBX2.
DR InterPro; IPR033773; CBX7_C.
DR InterPro; IPR016197; Chromo-like_dom_sf.
DR InterPro; IPR000953; Chromo/chromo_shadow_dom.
DR InterPro; IPR023780; Chromo_domain.
DR InterPro; IPR023779; Chromodomain_CS.
DR PANTHER; PTHR46860; CHROMOBOX PROTEIN HOMOLOG 2; 1.
DR PANTHER; PTHR46860:SF1; CHROMOBOX PROTEIN HOMOLOG 2; 1.
DR Pfam; PF17218; CBX7_C; 1.
DR Pfam; PF00385; Chromo; 1.
DR SMART; SM00298; CHROMO; 1.
DR SUPFAM; SSF54160; Chromo domain-like; 1.
DR PROSITE; PS00598; CHROMO_1; 1.
DR PROSITE; PS50013; CHROMO_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000029965}.
FT DOMAIN 12..70
FT /note="Chromo"
FT /evidence="ECO:0000259|PROSITE:PS50013"
FT REGION 61..182
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..346
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 374..491
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 102..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..173
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..491
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 530 AA; 55968 MW; 817E77F1157EA141 CRC64;
MEELSSVGEQ VFAAECILSK RLRKGKLEYL VKWRGWSSKH NSWEPEENIL DPRLLLAFQK
KEHEKEVQNR KRGKRPRGRP RKLTAVSSCS RRSKLKEPDA PSKSKSSSSS SSSTSSSSSS
DEEDDSDLDA KRGPRGRDTH PVPQKKAQIL VAKPELKDPI RKKRGRKPLP PEQKATRRPV
SLAKVLKTAR KDMGAPASKL PPPLSAPVAG LAALKAHAKE ACGSPSAMAT PENLASLMKG
MASSPGRGGI SWQSSIVHYM NRMTQSQAAS RLALKAQATT KCGLGLDLKV RTQKGELGMN
PPGSKIPKAP SSGAVEQKVG STGGPTHTHG ASRVPAGCPG PQSAPTQELS LQVLDLQSVK
NGMPGVGLLA RHATTTKGVP ATNPVPGKGT GSGLIGGSGA AMPTDTSKSE KLASRAVAPP
TPAGKRDYVK GSATPSGQES RTAPGEARKA ATLPEMSAGE ESSSSDSDPD STSPPSTGQN
PSVSVQTSQD WKPTRSLIEH VFVTDVTANL ITVTVKESPT SVGFFNLRHY
//
