ID A0A0D9S576_CHLSB Unreviewed; 777 AA.
AC A0A0D9S576;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Hyperpolarization activated cyclic nucleotide gated potassium channel 3 {ECO:0000313|Ensembl:ENSCSAP00000016015.1};
GN Name=HCN3 {ECO:0000313|Ensembl:ENSCSAP00000016015.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000016015.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000016015.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000016015.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the potassium channel HCN family.
CC {ECO:0000256|ARBA:ARBA00006305}.
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DR EMBL; AQIB01138894; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007975044.1; XM_007976853.1.
DR AlphaFoldDB; A0A0D9S576; -.
DR STRING; 60711.ENSCSAP00000016015; -.
DR Ensembl; ENSCSAT00000016509.1; ENSCSAP00000016015.1; ENSCSAG00000002020.1.
DR GeneID; 103223882; -.
DR KEGG; csab:103223882; -.
DR CTD; 57657; -.
DR eggNOG; KOG0498; Eukaryota.
DR GeneTree; ENSGT00940000162023; -.
DR OMA; QIAYHYL; -.
DR OrthoDB; 74296at2759; -.
DR BioGRID-ORCS; 103223882; 1 hit in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 20.
DR Bgee; ENSCSAG00000002020; Expressed in liver and 4 other cell types or tissues.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005249; F:voltage-gated potassium channel activity; IEA:Ensembl.
DR GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:Ensembl.
DR GO; GO:0042391; P:regulation of membrane potential; IEA:Ensembl.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013621; Ion_trans_N.
DR InterPro; IPR003938; K_chnl_volt-dep_EAG/ELK/ERG.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45689; I[[H]] CHANNEL, ISOFORM E; 1.
DR PANTHER; PTHR45689:SF7; POTASSIUM_SODIUM HYPERPOLARIZATION-ACTIVATED CYCLIC NUCLEOTIDE-GATED CHANNEL 3; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08412; Ion_trans_N; 1.
DR PRINTS; PR01463; EAGCHANLFMLY.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 3: Inferred from homology;
KW cAMP {ECO:0000256|ARBA:ARBA00023149};
KW cAMP-binding {ECO:0000256|ARBA:ARBA00022566};
KW Ion channel {ECO:0000256|ARBA:ARBA00022461};
KW Ion transport {ECO:0000256|ARBA:ARBA00022461};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022566};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Sodium {ECO:0000256|ARBA:ARBA00023053};
KW Sodium channel {ECO:0000256|ARBA:ARBA00022461};
KW Sodium transport {ECO:0000256|ARBA:ARBA00023201};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022461}.
FT TRANSMEM 96..120
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 430..536
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 552..573
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 692..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..767
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 777 AA; 86260 MW; 9D6BA916D2673610 CRC64;
MEAEQGPAAG ASEGATPGLE APKVPPVAPR PATAASGPIP GSESEPKRRQ LGTLLQPTVN
KFSLRVFGSH KAVEIEQERV KSAGAWIIHP YSDFRFYWDL IMLLLMVGNL IVLPVGITFF
KEENSPPWIV FNVLSDTFFL LDLVLNFRTG IVVEEGAEIL LAPRAIRTRY LRTWFLVDLI
SSIPVDYIFL VVELEPRLDA EVYKTARALR IVRFTKILSL LRLLRLSRLI RYIHQWEEIF
HMTYDLASAV VRIFNLIGMM LLLCHWDGCL QFLVPMLQDF PPDCWVSINH MVNHSWGRQY
SHALFKAMSH MLCIGYGQQA PVGMPDVWLT MLSMIVGATC YAMFIGHATA LIQSLDSSRR
QYQEKYKQVE QYMSFHKLPA DTRQRIHEYY EHRYQGKMFD EESILGELSE PLREEIINFT
CRGLVAHMPL FAHADPSFVT AVLTKLRFEV FQPGDLVVRE GSMGRKMYFI QHGLLSVLAR
GARDTRLTDG SYFGEICLLT RGRRTASVRA DTYCRLYSLS VDHFNAVLEE FPMMRRAFET
VAMDRLRRIG KKNSILQRKR SEPSPGSSGG GIMEQHLVQH DRDMARGVRG LAPSTGARLS
GKPVLWEPLV HAPLQAAAVT SNVAIALTHQ RGPLPLSPDS PATLLARSAR RSAGSPASPL
VPVRAGPWAS TSRLPAPPAR TLHASLSRAG CSQVSLLGPP PGGGGRRLGP RGRPLSASQP
SLPQRATGDG SPGRKGSGNE RLPPSGLLAK PPRTAQPPRP PVPEPATPRG LQLSANM
//
