ID A0A0D9S6C4_CHLSB Unreviewed; 1067 AA.
AC A0A0D9S6C4;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE SubName: Full=Leucine rich repeats and immunoglobulin like domains 2 {ECO:0000313|Ensembl:ENSCSAP00000016413.1};
GN Name=LRIG2 {ECO:0000313|Ensembl:ENSCSAP00000016413.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000016413.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000016413.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000016413.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AQIB01086177; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01086178; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01086179; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01086180; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01086181; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01086182; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01086183; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01086184; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9S6C4; -.
DR STRING; 60711.ENSCSAP00000016413; -.
DR Ensembl; ENSCSAT00000016918.1; ENSCSAP00000016413.1; ENSCSAG00000001617.1.
DR eggNOG; KOG4194; Eukaryota.
DR GeneTree; ENSGT00940000158791; -.
DR OMA; QVTMNHN; -.
DR Proteomes; UP000029965; Chromosome 20.
DR Bgee; ENSCSAG00000001617; Expressed in Ammon's horn and 7 other cell types or tissues.
DR GO; GO:0030426; C:growth cone; IEA:Ensembl.
DR GO; GO:0097708; C:intracellular vesicle; IEA:Ensembl.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005102; F:signaling receptor binding; IEA:Ensembl.
DR GO; GO:0060384; P:innervation; IEA:Ensembl.
DR GO; GO:0006509; P:membrane protein ectodomain proteolysis; IEA:Ensembl.
DR GO; GO:0048681; P:negative regulation of axon regeneration; IEA:Ensembl.
DR GO; GO:0051045; P:negative regulation of membrane protein ectodomain proteolysis; IEA:Ensembl.
DR GO; GO:2000010; P:positive regulation of protein localization to cell surface; IEA:Ensembl.
DR GO; GO:0034394; P:protein localization to cell surface; IEA:Ensembl.
DR GO; GO:2001222; P:regulation of neuron migration; IEA:Ensembl.
DR GO; GO:0010640; P:regulation of platelet-derived growth factor receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0007605; P:sensory perception of sound; IEA:Ensembl.
DR CDD; cd05763; IgI_LRIG1-like; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR PANTHER; PTHR45842:SF19; LEUCINE-RICH REPEATS AND IMMUNOGLOBULIN-LIKE DOMAINS PROTEIN 2; 1.
DR PANTHER; PTHR45842; SYNAPTIC ADHESION-LIKE MOLECULE SALM; 1.
DR Pfam; PF07679; I-set; 2.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF01463; LRRCT; 1.
DR PRINTS; PR00019; LEURICHRPT.
DR SMART; SM00409; IG; 3.
DR SMART; SM00408; IGc2; 3.
DR SMART; SM00365; LRR_SD22; 7.
DR SMART; SM00369; LRR_TYP; 11.
DR SMART; SM00082; LRRCT; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 3.
DR SUPFAM; SSF52058; L domain-like; 1.
DR PROSITE; PS50835; IG_LIKE; 3.
DR PROSITE; PS51450; LRR; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..39
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 40..1067
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002346534"
FT TRANSMEM 805..831
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 498..597
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 604..693
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 698..784
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 966..994
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1067 AA; 118892 MW; 8A3518253E2AC781 CRC64;
MAPAPLGIPE EQLLGCRSGL LSRLLFLAQS ALFLLPAAGA GLCPAPCSCR IPLLDCSRRK
LPAPSWRALS GLLPPDTAIL DLSHNRLSNW NISLESQMLQ EVKMNYNELT EIPYFGEPTS
NITLLSLVHN IIPEINAQAL QFYPALQSLD LSSNIISEIK TSSFPHMQLK YLNLSNNRIT
TLEAGCFDNL SSSLLVVKLN RNRISMIPPK IFKLPHLQFL ELKRNRIKIV EGLTFQGLDS
LRSLKMQRNG ISKLKDGAFF GLNNMEELEL EHNNLTRVNK GWLYGLRMLQ QLYVSQNAIE
RISPDAWEFC QRLSELDLSY NQLTRLDESA FVGLSLLERL NLGDNRVTHI ADGVFRFLSN
LQTLDLRNNE ISWAIEDASE AFAGLTSLTK LILQGNQIKS ITKKAFIGLE SLEHLDLNNN
AIMSIQENAF SQTHLKELIL NTSSLLCDCH LKWLLQWLID NNFQHSVNVS CAHPEWLAGQ
SILNVDLKDF VCDDFLKPQI RTHPETIIAL RGMNVTLTCT AVSSSDSPMS TVWRKDSEIL
YDVDIENFVR YRQQAGEALE YTSILHLFNV NFTDEGKYQC IVTNHFGSNY SQKAKLTVNE
TEMPSFLKTP MDLTIRTGAM ARLECAAEGH PAPQISWQKD GGTDFPAARE RRMHVMPEDD
VFFIANVKIE DMGIYSCMAQ NIAGGLSANA SLTVLETPSF IRPLEDKTVT RGETAVLQCI
AGGSPAPRLN WTKDDGPLLV TERHFFAAAN QLLIIVDAGL EDAGKYTCIM SNTLGTERGH
IYLNVMSSPN CDSSQSSTGH EDDGWTTVGI VIIVVVCCVV GTSLIWVIVI YHMRRKNEDY
SITNTEELNL PADIPSYLSS QGTLSEPQEG YSNSEAGSHQ QLMPPANGYI HKGTDGGTGT
RVICSDCYDN ANIYSRTREY CPYTYIAEED VLDQTLSSLM VQMPKETYLA HLPQDTTALE
SLISSADGEP SAFPTNHERI SEKKLPSTPM SGETLQRPVW NINRELGLPH PPFSQQPVHE
SPQLHQNEGL AGLEPDCSAS SMSCHRLQDH GFVFSRTRNI QDGSEGT
//
