ID A0A0D9S7F0_CHLSB Unreviewed; 461 AA.
AC A0A0D9S7F0;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Phosphoinositide-3-kinase regulatory subunit 3 {ECO:0000313|Ensembl:ENSCSAP00000016789.1};
GN Name=PIK3R3 {ECO:0000313|Ensembl:ENSCSAP00000016789.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000016789.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000016789.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000016789.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the PI3K p85 subunit family.
CC {ECO:0000256|ARBA:ARBA00009442}.
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DR EMBL; AQIB01144884; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01144885; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01144886; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01144887; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007977113.1; XM_007978922.1.
DR AlphaFoldDB; A0A0D9S7F0; -.
DR SMR; A0A0D9S7F0; -.
DR STRING; 60711.ENSCSAP00000016789; -.
DR Ensembl; ENSCSAT00000017308.1; ENSCSAP00000016789.1; ENSCSAG00000001225.1.
DR KEGG; csab:103224900; -.
DR eggNOG; KOG4637; Eukaryota.
DR GeneTree; ENSGT00940000156259; -.
DR OMA; AQPHEKN; -.
DR OrthoDB; 2880119at2759; -.
DR BioGRID-ORCS; 103224900; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 20.
DR Bgee; ENSCSAG00000001225; Expressed in caudate nucleus and 7 other cell types or tissues.
DR GO; GO:0005942; C:phosphatidylinositol 3-kinase complex; IEA:Ensembl.
DR GO; GO:0046935; F:1-phosphatidylinositol-3-kinase regulator activity; IEA:Ensembl.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:Ensembl.
DR GO; GO:0002042; P:cell migration involved in sprouting angiogenesis; IEA:Ensembl.
DR GO; GO:0008286; P:insulin receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0043491; P:phosphatidylinositol 3-kinase/protein kinase B signal transduction; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; IEA:Ensembl.
DR GO; GO:0001934; P:positive regulation of protein phosphorylation; IEA:Ensembl.
DR CDD; cd09930; SH2_cSH2_p85_like; 1.
DR CDD; cd09942; SH2_nSH2_p85_like; 1.
DR Gene3D; 1.10.287.1490; -; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR InterPro; IPR032498; PI3K_P85_iSH2.
DR InterPro; IPR035020; PI3kinase_P85_cSH2.
DR InterPro; IPR035022; PI3kinase_P85_nSH2.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF10; PI3K21B, ISOFORM B; 1.
DR Pfam; PF16454; PI3K_P85_iSH2; 1.
DR Pfam; PF00017; SH2; 2.
DR PRINTS; PR00678; PI3KINASEP85.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00252; SH2; 2.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR PROSITE; PS50001; SH2; 2.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 65..160
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 358..452
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT COILED 181..208
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 246..294
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 461 AA; 54438 MW; 683BE059F7730249 CRC64;
MYNTVWSMDR DDADWREVMM PYSTELIFYI EMDPPALPPK PPKPMTSAVT NGMKDSSVSL
QDAEWYWGDI SREEVNDKLR DMPDGTFLVR DASTKMQGDY TLTLRKGGNN KLIKIYHRDG
KYGFSDPLTF NSVVELINHY HHESLAQYNP KLDVKLMYPV SRYQQDQLVK EDNIDAVGKK
LQEYHSQYQE KSKEYDRLYE EYTRTSQEIQ MKRTAIEAFN ETIKIFEEQC HTQEQHSKEY
IERFRREGNE KEIERIMMNY DKLKSRLGEI HDSKMRLEQD LKKQALDNRE IDKKMNSIKP
DLIQLRKIRD QHLVWLNHKG VRQKRLNAWL GIKNEDADEN YFINEEDENL PHYDEKTWFV
EDINRVQAED LLYGKPDGAF LIRESSKKGC YACSVVADGE VKHCVIYSTA RGYGFAEPYN
LYSSLKELVL HYQQTSLVQH NDSLNVRLAY PVHAQMPSLC R
//