ID A0A0D9S8K7_CHLSB Unreviewed; 4387 AA.
AC A0A0D9S8K7;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 45.
DE SubName: Full=Vacuolar protein sorting 13 homolog D {ECO:0000313|Ensembl:ENSCSAP00000017196.1};
GN Name=VPS13D {ECO:0000313|Ensembl:ENSCSAP00000017196.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000017196.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000017196.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000017196.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the VPS13 family.
CC {ECO:0000256|ARBA:ARBA00006545}.
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DR EMBL; AQIB01136461; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01136462; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01136463; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01136464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AQIB01136465; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007978691.1; XM_007980500.1.
DR STRING; 60711.ENSCSAP00000017196; -.
DR Ensembl; ENSCSAT00000017724.1; ENSCSAP00000017196.1; ENSCSAG00000000810.1.
DR GeneID; 103225585; -.
DR CTD; 55187; -.
DR eggNOG; KOG1796; Eukaryota.
DR eggNOG; KOG1809; Eukaryota.
DR GeneTree; ENSGT00950000183083; -.
DR OMA; LFGTCPT; -.
DR OrthoDB; 199953at2759; -.
DR BioGRID-ORCS; 103225585; 6 hits in 16 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 20.
DR Bgee; ENSCSAG00000000810; Expressed in Ammon's horn and 7 other cell types or tissues.
DR GO; GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
DR GO; GO:0007005; P:mitochondrion organization; IEA:Ensembl.
DR GO; GO:1901526; P:positive regulation of mitophagy; IEA:Ensembl.
DR CDD; cd14306; UBA_VP13D; 1.
DR Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR InterPro; IPR015940; UBA.
DR InterPro; IPR009060; UBA-like_sf.
DR InterPro; IPR041969; VP13D_UBA.
DR InterPro; IPR026847; VPS13.
DR InterPro; IPR026854; VPS13-like_N.
DR InterPro; IPR049424; VPS13_C.
DR InterPro; IPR031645; VPS13_DH-like.
DR InterPro; IPR031646; VPS13_extend_chorein.
DR InterPro; IPR031642; VPS13_mid_RBG.
DR InterPro; IPR009543; VPS13_VAB.
DR PANTHER; PTHR16166:SF141; INTERMEMBRANE LIPID TRANSFER PROTEIN VPS13D; 1.
DR PANTHER; PTHR16166; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN VPS13; 1.
DR Pfam; PF12624; Chorein_N; 1.
DR Pfam; PF00627; UBA; 1.
DR Pfam; PF21679; VPS13_C; 1.
DR Pfam; PF16909; VPS13_DH-like; 1.
DR Pfam; PF16908; VPS13_ext_chorein; 1.
DR Pfam; PF16910; VPS13_mid_rpt; 2.
DR Pfam; PF06650; VPS13_VAB; 1.
DR SMART; SM00165; UBA; 1.
DR SUPFAM; SSF46934; UBA-like; 1.
DR PROSITE; PS50030; UBA; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Lipid transport {ECO:0000256|ARBA:ARBA00023055};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 2633..2676
FT /note="UBA"
FT /evidence="ECO:0000259|PROSITE:PS50030"
FT REGION 404..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 745..795
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1037..1056
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1563..1582
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1741..1771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2070..2104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2123..2142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 100..127
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 747..766
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2070..2088
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4387 AA; 491572 MW; 75251729B6FB30C3 CRC64;
MLEGLVAWVL NTYLGKYVNN LNTDQLSVAL LKGAVELENL PLKKDALKEL ELPFEVKAGF
IGKVTLQIPF YRPHVDPWVI SISSLHLIGA PEKIQDFNDE KEKLLERERK KALLQALEEK
WKNERQQKGE SYWYSVTASV VTRIVENIEL KIQDVHLRFE DGVTNPSHPF AFGICIKNVS
MQNAVNEPVQ KLMRKKQLDV AEFSIYWDVD CTLLGDLPQV ELQEAMARSM ESRSHHYILE
PVFASALLKR NCSKKPLRSR HSPRIDCDIQ LETIPLKLSQ LQYRQIMEFL KELERKERQV
KFRRWKPKVA ISKNCREWWY FALNANLYEI REQRKRCTWD FMLHRARDAV SYTDKYFNKL
KGGLLSADDK EEMCRIEEEQ SFEELKILRE LVHDRFHKQE ELAESLREPQ FDSPGASPGD
PEPGGGSGML QYLQSWFPGW GGWYGQQTSE GNVVEGLSAE QQEQWIPEEI LGTEEFFDPT
ADASCMNTYT KRDHVFAKLN LQLQRGTVTL LHKEQGTPQM NESAFMQLEF SDVKLLAESL
PRRNSSLLSV RLGGLFLRDL ATEGTMFPLL VFPNPQKEVG RVSQSFGVQT ISADRSDHYP
ATDPDDPVFE MLYERNPAHS HFERRLNVST RPLNIIYNPQ AIKKVADFFY KGKVHTSGFG
YQSELELRVA EAARRQYNKL KMQTKAEIRQ TLDRLLVGDF IEESKRWTVR LDISAPQVIF
PDDFKFKNPV LVVVDLGRML LTNTQDNSRR KSRDGSASEE TQFSDDEYKT PLATPPNTPP
PESNSSNGEK TPPFSGVEFS EEQLQAHLMS TKMYERYSLS FMDLQIMVGR VKDNWKHVQD
IDVGPTHVVE KFDVHLQLER RLIYTSDPKY PGAVLSGNLP DLKIHINEDK ISALKNCFAL
LTTPEMKTSD TQIKEKIFPQ EEQRGSLQDS VMNLTQSIVM LEQHTREVLV ESQLLLAEFK
VNCMQLGVES NGRYISVLKV FGTNAHFVKR PYDAEVSLTV HGLLLVDTMQ TYGADFDLLM
ASHKNLSFDI PTGSLRDSRA QSPVSGPNAT HLTDGATLNN RSATSVSLDK ILTKEQESLI
KLEYQFVSSE CPSMNLDSTL QVISLQVNNL DIILNPETIV ELIGFLQKSF PKEKDDLSPQ
PLMTDFERSF REQGTYQSTY EQNTEVAVEI HRLNLLLLRT VGMANGEKYG RKIATASIGG
TKVNVSMGST FDMNGSLGCL QLMDLTQDNV KNQYVVSIGN SVGYENIISD IGYFESVFVR
MEDAALTEAL SFTFVEKSKQ ECFLNLKMAS LHYNHSAKFL KELTLSMDEL EENFRSMLKS
AASKVTTVLA TKTAEYSEMV SLFETPRKTR EPFILEENEI YGFDLASSPS DTVKLILNIN
IESPVVSIPR KPGSPELLVG HLGQIFIQNF VAGDDESRSD RLQVEIKDIK LYSLNCTQLA
GREAVGSEGS RTFCPPSGSG SANSQEEAHF TRHDFFESLH RGQAFHILNN TTIQFKLEKI
PIERESELTF SLSPDDLGTS SIMKIEGKFV NPVQVVLAKH VYEQVLQTLD NLVYSEDLNK
YPASATSSPC PDSPLPPLST CGESSVERKE NGLFSHSSLS NTSQKSLSVK EVKSFTQIQA
TFCISELQVQ LSGDLTLGAQ GLVSLKFQDF EVEFSKDHPQ TLSIQIALHS LLMEDLLEKN
PDSKYKNLMV SRGAPKPSTL AQKEYLSQSC PSVSNVEYPD MPRSLPSHME EAPNVFQLYQ
RPTSASRKKQ KEVQDKDYPL TPPPSPTADE PKILAGKSKF DDSLVHINIF LVDKKHPEFS
SSYNRVNRSI DVDFNCLDVL ITLQTWVVIL DFFGIGSTAD NHAMRLPPEG ILHNVKSEPH
ASMESGLQDP VNTKLDLKVH SLSLVLNKTT SELAKANVSK LVAHLEMIEG DLALQGSIGS
LSLSDLTSHG EFYRERFTTS GEEALIFQTF KYGRPDPLLR REHDIRVSLR MASVQYVHTQ
RFQAEVVAFI QHFTQLQDVL GRQRAAIEGQ TVRDQAQRCS RVLLDIEAGA PVLLIPESSR
SNNLIVANLG KLKVKNKFLF AGFPGTFSLQ DKESVPSASP TGTPKHSLRK TTSTEEPRGT
HSQGQFMLPL AGMSLGSLKS EFVPSTSTKQ RGPQPTLSVG QVSSSPEDHV CLLDCIVVDL
QDMDIFAAER HPREYSKAPE DSSGDLIFPS YSVRQTGGSL LTEPCRLKLQ VERNLDKEIS
HTVPDVSIHG NLSSVHCSLD LYKYKLIRGL LENNLGEPIE EFMRPYDLQD PRIHTVLSGE
VYTCMCFLID MVNVSLELKD PKRKEGAGSL ARFDFKKCKL LYESFSNQTK SINLVSHSMM
AFDTRYAGQK TSPGMTNVFS CIFQPAKNSS TTQGSIQIEL HFRSTKDSSC FTVVLNNLRV
FLIFDWLLLV HDFLHTPSDI KKQNHVTPSR HRNSSSESAI VPKTVKSGVV TKRSSLPVSN
ERHLEVKVNV TGTEFVVVED VSCFDTNAII LKGTTVLTYK PRFVDRPFSG SLFGIEVFSC
RLGNEQDTAL SIVDPVQIQV ELVGNSSYQN SSGLMDAFNS EDFPPVLEIQ LQALDIRLSY
NDVQLFLAIA KSIPEQANAA VPDSVALASD SVGSYLPGAS RVGEEIREGT RHTLDPVLEL
QLARLQELGF SMDDCRKALL VCQGQLKKAA SWLFKNAEPL KSLSLASTSR DGPGAVAAPL
ISGVEIKAES VCICFIDDCM DCDVPLAELT FSRLNFLQRV RTSPEGYAHF TLSGDYYNRA
LSGWEPFIEP WPCSVSWQQQ AASRLHPPRL KLEAKAKPRL DINITSVLID QYVSTKESWM
ADYCKDDKEI ESTKSEDWMG SSVDPPCFGQ SLPLVYLRTR STASLTNLEH QIYARDVKTP
KRRQPFVPFA LRNHTGCTLW FATLTTTPTR AALSHSGSPG VVPEGNGTFL DDTHNVSEWR
EVLTGEEIPF EFEARGKLRH RHTHDLRIHQ LQVRVNGWEQ VSPVSVDKVG TFFRYAAPDK
NSSSSTIGSP SSRTNIIHPQ VYFSSLPPVR VVFAVTMEGS ARKVITVRSA LIVRNRLETP
MELRLDSPSA PDKPVVLPAI MPGDSFAVPL HLTSWRLQAR PKGLGVFFCK APIHWTNVVK
TAEISSSKRE CHSMDTEKSR FFRFCVAIKK ENYPDYMPSN IFSDSAKQIF RQPGHTIYLL
PTVVICNLLP CELDFYVKGM PINGTLKPGK EAALHTADTS QNIELGVSLE NFPLCKELLI
PPGTQNYMVR MRLYDINRRQ LNLTIRIVCR AEGSLKIFIS APYWLINKTG LPLIFRQDNA
KTDAAGQFEE HELARSLSPL LFCYADKEQP NLCTMRIGRG IHPEGMPGWC QGFSLDGGSG
VRALKVIQQG NRPGLIYNIG IDVKKGRGRY IDTCMVIFAP RYLLDNKSSH KLAFAQREFA
RGQGTANPEG YISTLPGSSV VFHWPRNDYD QLLCVRLMDV PNCIWSGGFE VNKNNSFHIN
MRDTLGKCFF LRVEITLRGA TYRISFSDTD QLPPPFRIDN FSKVPVVFTQ HGVAEPRLRT
EVKPMTSLDY AWDEPTLPPF ITLTVKGAGS SEINCNMNDF QDNRQLYYEN FIYIAATYTF
SGLQEGTGRP VASNKAITCA ELVLDVSPKT QRVILKKKEP GKRSQLWRMT GTGMLAHEGS
SVPHNPNKPS AARSTEGSAI LDIAGLAAVT DNRYEPLMLR KPDRRRSTTQ TWSFREGKLT
CGLHGLVVQV KGGLSGLFDG AEVVLGPDTS MELLGPVPPE QQFINQKMRP GSGMLSIRVI
PDGPTRALQI TDFCQRKSNR SYEVDELPVT EQELQKLKNP DTEQELEVLV RLEGGIGLSL
INKVPEELVF ASLTGISVHY TQLATSHMLE LSIRDVQVDN QLIGTTQPFM LYVTPLSNEN
EVIETGPAVQ VNAVKFPSKS ALTNIYKHLM VTAQRFTVQI EEKLLLKLLS FFGYDQAESE
VEKYDENLHE KTAEQGGTPI RYYFENLKIS IPQIKLSVFT SNKLPLDLKA LKSTLGFPLI
RFEDAVINLD PFTRVHPYET KEFIINDVLK HFQEELLSQA ARILGSVDFL GNPMGLLNDV
SEGVTGLIKY GNVGGLIRNV THGVSNSAAK FAGTLSDGLG KTMDNRHQSE REYIRYHAAT
SGEHLVAGIH GLAHGIIGGL TSVITSTVEG VKTEGGVSGF ISGLGKGLVG TVTKPVAGAL
DFASETAQAV RDTATLSGPR TQAQRVRKPR CCMGPQGLLP RYSESQAEGQ EQLFKLTDNI
QDEFFIAVEN IDSYCVLISS KAVYFLKSGD YVDREAIFLE VKYDDLYHCL VSKDHGKVYV
QVTKKAVSTS SGVSIPGPSH QKPMVHVKSE VLAVKLSQEI NYAKSLYYEQ QLMLRLSENR
EQLELDS
//
