ID A0A0D9SAB4_CHLSB Unreviewed; 543 AA.
AC A0A0D9SAB4;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Gap junction protein {ECO:0000256|RuleBase:RU000630};
GN Name=GJA10 {ECO:0000313|Ensembl:ENSCSAP00000017803.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000017803.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000017803.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000017803.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: One gap junction consists of a cluster of closely packed
CC pairs of transmembrane channels, the connexons, through which materials
CC of low MW diffuse from one cell to a neighboring cell.
CC {ECO:0000256|RuleBase:RU000630}.
CC -!- SUBUNIT: A connexon is composed of a hexamer of connexins.
CC {ECO:0000256|RuleBase:RU000630}.
CC -!- SUBCELLULAR LOCATION: Cell junction, gap junction
CC {ECO:0000256|ARBA:ARBA00004610}. Cell membrane
CC {ECO:0000256|ARBA:ARBA00004651, ECO:0000256|RuleBase:RU000630}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004651,
CC ECO:0000256|RuleBase:RU000630}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the connexin family.
CC {ECO:0000256|RuleBase:RU000630}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AQIB01122841; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_008004828.1; XM_008006637.1.
DR AlphaFoldDB; A0A0D9SAB4; -.
DR STRING; 60711.ENSCSAP00000017803; -.
DR Ensembl; ENSCSAT00000018343.1; ENSCSAP00000017803.1; ENSCSAG00000000192.1.
DR GeneID; 103240112; -.
DR KEGG; csab:103240112; -.
DR CTD; 84694; -.
DR eggNOG; ENOG502QQPH; Eukaryota.
DR GeneTree; ENSGT01090000260070; -.
DR OMA; SPCPWDD; -.
DR OrthoDB; 5301774at2759; -.
DR BioGRID-ORCS; 103240112; 3 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 13.
DR Bgee; ENSCSAG00000000192; Expressed in caudate nucleus.
DR GO; GO:0005922; C:connexin complex; IEA:InterPro.
DR GO; GO:0005243; F:gap junction channel activity; IEA:Ensembl.
DR GO; GO:0007154; P:cell communication; IEA:InterPro.
DR GO; GO:0050908; P:detection of light stimulus involved in visual perception; IEA:Ensembl.
DR GO; GO:0007276; P:gamete generation; IEA:Ensembl.
DR GO; GO:0007416; P:synapse assembly; IEA:Ensembl.
DR Gene3D; 1.20.1440.80; Gap junction channel protein cysteine-rich domain; 1.
DR InterPro; IPR000500; Connexin.
DR InterPro; IPR019570; Connexin_CCC.
DR InterPro; IPR017990; Connexin_CS.
DR InterPro; IPR013092; Connexin_N.
DR InterPro; IPR038359; Connexin_N_sf.
DR PANTHER; PTHR11984; CONNEXIN; 1.
DR PANTHER; PTHR11984:SF9; GAP JUNCTION ALPHA-10 PROTEIN; 1.
DR Pfam; PF00029; Connexin; 1.
DR PRINTS; PR00206; CONNEXIN.
DR SMART; SM00037; CNX; 1.
DR SMART; SM01089; Connexin_CCC; 1.
DR PROSITE; PS00407; CONNEXINS_1; 1.
DR PROSITE; PS00408; CONNEXINS_2; 1.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022949};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Gap junction {ECO:0000256|ARBA:ARBA00022868,
KW ECO:0000256|RuleBase:RU000630};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000630};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 78..100
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..178
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 210..235
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 43..76
FT /note="Connexin N-terminal"
FT /evidence="ECO:0000259|SMART:SM00037"
FT DOMAIN 167..233
FT /note="Gap junction protein cysteine-rich"
FT /evidence="ECO:0000259|SMART:SM01089"
FT REGION 381..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 381..395
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 398..417
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 543 AA; 62001 MW; 2998257C5C6874A7 CRC64;
MGDWNLLGGI LEEVHSHSTI VGKIWLTILF IFRMLVLRVA AEDVWDDEQS AFDCNTRQPG
CNNICYDDAF PISLIRFWVL QIIFVSSPSL VYMGHALYRL RAFEKERQRK KSHLRAQMEN
PELDLEEQQR IDRELRRLEE QKRIHKVPLK GCLLRTYVLH ILTRSVLEVG FMIGQYILYG
FQMHPLYKCT QPPCPNAVDC FVSRPTEKTI FMLFMHSIAA ISLLLNILEI FHLGIRKIMR
TLYKKSSGEG IEDETGPPFH LKKYSVAQQC MICSSLPETI SPLQANNQQQ VIRVNVPKSK
TMWQIPQPRQ LEVDPSNGKK DWSEKDQHIG QLHVHSPCPW AGSAGNQHLG QQSDQSSFGL
QNTMSQSWLG TTTAPRNCPS YAIGTWEQSQ DPEPSGEPLT DLHSHCRDSE GSMRESGVWI
ERSRPGSRKA SFLSRLLSEK RHLHSDSGSS GSRNSSCLDF PHWENSPSPL PSVPGHRTSM
VRQTALSIME LSQKLFHPGC FLFPFFLPGV CMYVSVDREA DGEGDYLWRD KIIHSIHSVK
FNS
//
