ID A0A0D9SAV4_CHLSB Unreviewed; 548 AA.
AC A0A0D9SAV4;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=Inositol 1,4,5-trisphosphate receptor-interacting protein {ECO:0000256|ARBA:ARBA00019443};
GN Name=ITPRIP {ECO:0000313|Ensembl:ENSCSAP00000017993.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000017993.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000017993.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000017993.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (JUL-2023) to UniProtKB.
CC -!- FUNCTION: Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-
CC triphosphate receptor (ITPR) Ca(2+) release.
CC {ECO:0000256|ARBA:ARBA00003856}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-pass type I membrane
CC protein {ECO:0000256|ARBA:ARBA00004479}. Nucleus outer membrane
CC {ECO:0000256|ARBA:ARBA00004494}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004494}.
CC -!- SIMILARITY: Belongs to the ITPRIP family.
CC {ECO:0000256|ARBA:ARBA00005554}.
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DR EMBL; AQIB01042514; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A0A0D9SAV4; -.
DR STRING; 60711.ENSCSAP00000017993; -.
DR Ensembl; ENSCSAT00000018541.1; ENSCSAP00000017993.1; ENSCSAG00000018451.1.
DR eggNOG; ENOG502QRDF; Eukaryota.
DR GeneTree; ENSGT01050000244827; -.
DR OMA; CHLHCLQ; -.
DR Proteomes; UP000029965; Chromosome 9.
DR Bgee; ENSCSAG00000018451; Expressed in fibroblast and 4 other cell types or tissues.
DR GO; GO:0005640; C:nuclear outer membrane; IEA:Ensembl.
DR GO; GO:0004860; F:protein kinase inhibitor activity; IEA:Ensembl.
DR GO; GO:0008625; P:extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR GO; GO:1902042; P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; IEA:Ensembl.
DR Gene3D; 1.10.1410.40; -; 1.
DR InterPro; IPR026250; ITPRIP-like.
DR InterPro; IPR024810; Mab-21-like.
DR InterPro; IPR046906; Mab-21_HhH/H2TH-like.
DR PANTHER; PTHR10656; CELL FATE DETERMINING PROTEIN MAB21-RELATED; 1.
DR PANTHER; PTHR10656:SF8; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR-INTERACTING PROTEIN; 1.
DR Pfam; PF20266; Mab-21_C; 1.
DR PRINTS; PR02107; INOS145TPRIP.
DR SMART; SM01265; Mab-21; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..15
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 16..548
FT /note="Inositol 1,4,5-trisphosphate receptor-interacting
FT protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012633253"
FT DOMAIN 425..479
FT /note="Mab-21-like HhH/H2TH-like"
FT /evidence="ECO:0000259|Pfam:PF20266"
FT COILED 38..79
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 548 AA; 62296 MW; AFAA0BE6DA4FD1EE CRC64;
MAMGLFRVCL VVVTAIINHP LLFPRENTTV PENEEEIIRK MQAHQEKLQL EQLRLEEEVA
RLAAEKEALE QVAEEGRQQN ETRVAWDLWS TLCMILFLMI EVWRQDHQEA PSPECLGGEE
DELPGLGGAP LQGLTLPNKA TLGHFYERCI RGATADAART REFLEGFVDD LLEALRSLCN
RDTDMEVEDF IGVDSMYENW QVDRPLLCHL FVPFTPPEPY RFHPELWCSG RSVPLDRQGY
GQIKVVRADG DTLSCICGKT KLGEDMLCLL HGRNSMAPPC GNMENLLCAT DSLYLDTMQV
MKWFQMALTR AWHGIAHKYE FDLAFGQLDS PGSLKIKFRS GKFMPFNLIP VIQCDDSDLY
FVSHLPREPS EGTPASSTDW LLSFAVYERH FLRMTLKALP EGACHLSCLQ IASFLLSKQS
RLTGPSGLSS YHLKTALLHL LLLRQAADWK AGQLDARLHE LLCFLEKSLL EKKLHHFFIG
NRKVPEAMGL PEAVLRAEPL NLFRPFVLQR SLYRKTLDSF YEMLKNAPAL ISEYSLHVPS
DHASLPQK
//