ID A0A0D9SCB3_CHLSB Unreviewed; 299 AA.
AC A0A0D9SCB3;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE RecName: Full=Taste receptor type 2 {ECO:0000256|RuleBase:RU004424};
GN Name=TAS2R1 {ECO:0000313|Ensembl:ENSCSAP00000018502.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000018502.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000018502.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000018502.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Receptor that may play a role in the perception of bitterness
CC and is gustducin-linked. May play a role in sensing the chemical
CC composition of the gastrointestinal content. The activity of this
CC receptor may stimulate alpha gustducin, mediate PLC-beta-2 activation
CC and lead to the gating of TRPM5. {ECO:0000256|ARBA:ARBA00024847}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU004424}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU004424}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor T2R family.
CC {ECO:0000256|ARBA:ARBA00007376, ECO:0000256|RuleBase:RU004423}.
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DR EMBL; AQIB01112534; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007959387.1; XM_007961196.1.
DR AlphaFoldDB; A0A0D9SCB3; -.
DR STRING; 60711.ENSCSAP00000018502; -.
DR Ensembl; ENSCSAT00000019077.1; ENSCSAP00000018502.1; ENSCSAG00000018987.1.
DR GeneID; 103214997; -.
DR KEGG; csab:103214997; -.
DR CTD; 50834; -.
DR eggNOG; ENOG502S2SI; Eukaryota.
DR GeneTree; ENSGT01100000263477; -.
DR OMA; KQRKMIP; -.
DR OrthoDB; 5266232at2759; -.
DR BioGRID-ORCS; 103214997; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 4.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProt.
DR GO; GO:0033038; F:bitter taste receptor activity; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd15016; 7tm_TAS2R1; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR007960; TAS2R.
DR PANTHER; PTHR11394; TASTE RECEPTOR TYPE 2; 1.
DR PANTHER; PTHR11394:SF47; TASTE RECEPTOR TYPE 2 MEMBER 1-RELATED; 1.
DR Pfam; PF05296; TAS2R; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU004424};
KW Membrane {ECO:0000256|RuleBase:RU004424, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU004424};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606,
KW ECO:0000256|RuleBase:RU004424};
KW Taste {ECO:0000256|ARBA:ARBA00022480, ECO:0000256|RuleBase:RU004424};
KW Transducer {ECO:0000256|RuleBase:RU004424};
KW Transmembrane {ECO:0000256|RuleBase:RU004424, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 6..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 57..87
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 93..118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 130..156
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 176..201
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 222..243
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 258..280
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
SQ SEQUENCE 299 AA; 34134 MW; 012F1604A59F3FEF CRC64;
MLESHLIIYF LLAVIQFLLG TFTNGIIVVV NGIDLIKHRK MAPLDLLLSC LAVSRIFLQL
FIFYINVVVI FLIEFITCSA SCAFLVFVNE LELWLATWLG VFYCAKVASV PHPLFIWLKM
RISKSVPWMI LGSLLYVSMI CIFHIKYTGF MVPYFLRNLF FQNATIQTEV KQAIQIFSFV
AELLVPLLIF LVAVLLLIFS LGRHTRQMRN TVAGSRVPGR GAHISALLSI LSFLILYISH
YLIKTFLSSL KFHVKRFVFL FCILVIGTYP SGHSLILILG NPKLKQNTKK FLCHSKCCQ
//
