ID A0A0D9SD55_CHLSB Unreviewed; 259 AA.
AC A0A0D9SD55;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Sesquipedalian {ECO:0000256|RuleBase:RU369082};
DE Short=Ses {ECO:0000256|RuleBase:RU369082};
DE AltName: Full=PH domain-containing endocytic trafficking adaptor {ECO:0000256|RuleBase:RU369082};
GN Name=PHETA2 {ECO:0000313|Ensembl:ENSCSAP00000018794.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000018794.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000018794.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000018794.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Plays a role in endocytic trafficking. Required for receptor
CC recycling from endosomes, both to the trans-Golgi network and the
CC plasma membrane. {ECO:0000256|RuleBase:RU369082}.
CC -!- SUBUNIT: Forms homodimers and heterodimers with PHETA. Interacts with
CC OCRL and INPP5B. {ECO:0000256|RuleBase:RU369082}.
CC -!- SUBCELLULAR LOCATION: Early endosome {ECO:0000256|RuleBase:RU369082}.
CC Recycling endosome {ECO:0000256|RuleBase:RU369082}. Golgi apparatus,
CC trans-Golgi network {ECO:0000256|RuleBase:RU369082}. Cytoplasmic
CC vesicle, clathrin-coated vesicle {ECO:0000256|RuleBase:RU369082}.
CC -!- SIMILARITY: Belongs to the sesquipedalian family.
CC {ECO:0000256|RuleBase:RU369082}.
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DR EMBL; AQIB01149018; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007974139.1; XM_007975948.1.
DR RefSeq; XP_007974140.1; XM_007975949.1.
DR RefSeq; XP_007974141.1; XM_007975950.1.
DR RefSeq; XP_007974143.1; XM_007975952.1.
DR RefSeq; XP_007974144.1; XM_007975953.1.
DR RefSeq; XP_007974145.1; XM_007975954.1.
DR AlphaFoldDB; A0A0D9SD55; -.
DR Ensembl; ENSCSAT00000019374.1; ENSCSAP00000018794.1; ENSCSAG00000019284.1.
DR GeneID; 103223408; -.
DR KEGG; csab:103223408; -.
DR CTD; 150368; -.
DR eggNOG; ENOG502QQ94; Eukaryota.
DR GeneTree; ENSGT00940000162686; -.
DR OMA; WELQGPT; -.
DR OrthoDB; 5483476at2759; -.
DR BioGRID-ORCS; 103223408; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 19.
DR Bgee; ENSCSAG00000019284; Expressed in fibroblast and 3 other cell types or tissues.
DR GO; GO:0030136; C:clathrin-coated vesicle; IEA:UniProtKB-SubCell.
DR GO; GO:0005829; C:cytosol; IEA:GOC.
DR GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0055037; C:recycling endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005802; C:trans-Golgi network; IEA:UniProtKB-UniRule.
DR GO; GO:0042803; F:protein homodimerization activity; IEA:Ensembl.
DR GO; GO:0007032; P:endosome organization; IEA:UniProtKB-UniRule.
DR GO; GO:0001881; P:receptor recycling; IEA:UniProtKB-UniRule.
DR GO; GO:0042147; P:retrograde transport, endosome to Golgi; IEA:UniProtKB-UniRule.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR045188; Boi1/Boi2-like.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR22902; SESQUIPEDALIAN; 1.
DR PANTHER; PTHR22902:SF15; SESQUIPEDALIAN-2; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Cytoplasmic vesicle {ECO:0000256|RuleBase:RU369082};
KW Endosome {ECO:0000256|RuleBase:RU369082};
KW Golgi apparatus {ECO:0000256|RuleBase:RU369082};
KW Phosphoprotein {ECO:0000256|RuleBase:RU369082};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965}.
FT DOMAIN 17..121
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 155..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 164..178
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 259 AA; 28344 MW; 4F38B254217E8A04 CRC64;
MKLNERSVAH YALSDSPADH TGFLRTWGGP GTPSTPSGTG RRCWFVLKGN LLFSFESREG
RAPLSLVVLE GCTVELAEAP VPEEFAFAIC FDAPGVRPHL LAAEGPAAQE AWVKALSRAS
FGYMRLVVRE LESQLQDARQ SLALQRRSSW KSVAGRCKPQ APNHQSVGLE NGHSLSKDSS
PVGLVEEGGS RSSGRGLAEW ELQGPASLLL GRGQSPVSPE TSCFSTLHDW YGQEIMELRQ
CWQQRAQRSQ PKCEEQDKP
//
