ID A0A0D9SD58_CHLSB Unreviewed; 2256 AA.
AC A0A0D9SD58;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Polycystin family receptor for egg jelly {ECO:0000313|Ensembl:ENSCSAP00000018797.1};
GN Name=PKDREJ {ECO:0000313|Ensembl:ENSCSAP00000018797.1};
OS Chlorocebus sabaeus (Green monkey) (Cercopithecus sabaeus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Chlorocebus.
OX NCBI_TaxID=60711 {ECO:0000313|Ensembl:ENSCSAP00000018797.1, ECO:0000313|Proteomes:UP000029965};
RN [1] {ECO:0000313|Ensembl:ENSCSAP00000018797.1, ECO:0000313|Proteomes:UP000029965}
RP NUCLEOTIDE SEQUENCE.
RA Warren W., Wilson R.K.;
RL Submitted (MAR-2014) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSCSAP00000018797.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; AQIB01150664; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_007974291.1; XM_007976100.1.
DR STRING; 60711.ENSCSAP00000018797; -.
DR Ensembl; ENSCSAT00000019377.1; ENSCSAP00000018797.1; ENSCSAG00000019287.1.
DR GeneID; 103223494; -.
DR KEGG; csab:103223494; -.
DR CTD; 10343; -.
DR eggNOG; KOG3599; Eukaryota.
DR GeneTree; ENSGT00940000162080; -.
DR OMA; KNHMWFS; -.
DR OrthoDB; 52189at2759; -.
DR BioGRID-ORCS; 103223494; 0 hits in 9 CRISPR screens.
DR Proteomes; UP000029965; Chromosome 19.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0034220; P:monoatomic ion transmembrane transport; IEA:UniProtKB-KW.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR014010; REJ_dom.
DR PANTHER; PTHR10877:SF150; POLYCYSTIC KIDNEY DISEASE AND RECEPTOR FOR EGG JELLY-RELATED PROTEIN; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF02010; REJ; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS51111; REJ; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000029965};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..2256
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002346684"
FT TRANSMEM 1188..1209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1393..1411
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1431..1453
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1575..1601
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1613..1635
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1710..1734
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1968..1988
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2000..2020
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2040..2066
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2087..2114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2149..2175
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 219..916
FT /note="REJ"
FT /evidence="ECO:0000259|PROSITE:PS51111"
FT DOMAIN 1233..1350
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 1495..1564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1517..1531
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1534..1549
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1550..1564
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1809..1826
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
SQ SEQUENCE 2256 AA; 256163 MW; 579411994680400C CRC64;
MRPGPALLLL GLGLGLGLGL GLSLGRLPLP PAPREAQAAV PGAPGGLLRG AQGLGVRGGR
ALLSLRPSAV RAGGVVLSGR GSLCFPRGGA RWRWYCLVLR VLLSAQRLPR PAAPTLVDLQ
LTARGGRLSL TWSAPLPRWP RRLAWAFRLR LLGPGAARPA SPAARVFPRS AAPGPRPQPG
FVARTECPTD GPARLMLQAV NSSRHRAVES SVSCQINTCV IQSVRINTDQ RGAPVRLSMK
AEATLNASVQ LDCPAALAIS QYWQVFSVPA VGDAPDWTQP LDVPQLEIRN SPMFIHIPSN
SLQWGVYVFN FTVSITTRNP KMPEVKDSDA VYVWIVRSSL QAVMLGDVNI TANFTEQLIL
DGSTSSDPDA DSPLQGLQFF WYCTTDPRNY RGDRIILGSK EVCHPEQANL KWPWATGPVL
TLLPETLKGD HVYFFRMVIQ KDSRTAFSDK RVHVLQGPKT IAHITCIENC ERTFIVSDRF
SLFLNCTNCA SRDFYTWSIL SSSGGEMLFD WMGETVTGRN GAYLSIKAFA FQHFLEAEFS
ISLHLASWSG VTSVFRHSFI INHGPQIGEC KINPAKGIAL ITKFVVQCSN FRDKHVPLTY
KIIVSDLHSV GEISSVKENT LGTILYLGPQ STSPPSFLPV GMVANQYALK IYVQVYDSLG
AFSQVTLHAT AQAPTDKNSS KTVLNQLLSF TMGPSSLLST LIQKQDFLPA GYLLYIVASV
LNNMRTELPL QNDRVSLRKH LIDQSFLLPV STLVEIGQVV MTITKLTQKP SEFTWDAQKR
ATMRIWQANQ ALQEYQQKDK RFRSEQIEIM STGILMSLSN ILKMTSHQVV KDPFYVIESL
SDTILANKVP GNKTTSMRTP NFNMYVKKVE KWGVTQVFGN EKHCRNCFYP TLNASSVPGL
SANAPISTMF CDFTNDPFPW LNDQENTSVQ VFGFRMTGVA DNGSVVEITP DVAEVYLVRK
NLTFAAFNLT VGPNGDVDGS SKTTTGGFSF QVDSRVLREV LVHIVTEVMV LFTVLVYTGS
QITPTALLAT FLVPHDIPPV ASQSALFDPA CRVKKARVVC LPVSLLQLIA QHSHSPHCTV
SIVLQAPRFV MKPNDKLVRI SIFSIQCLDM YGIQSEWREG YCVLGEKTSW HNVHCICKNI
VRARRQLGIV GLTNIHLQTH YVMAKVIVIP NPVDLRLNII KSLHRNPVTF FTVLFIILLY
VILAFWALYR DEIDQHLRGH VIVLPDNDPY DNLCYLVTIF TGSRWGSGTR ADVFVQLRGT
VSTSDVHCLS HPHFTTLYRG SINTFLLTTK SDLGDIHSIR VWHNNEGHSP SWYLSRIKVE
NLFSRHIWLF ICQKWLSIDT TLDRTFHVTH PDEPLTRKDF FFIDVSSNLQ KNHMWFSIFA
SVVAKTFNRL QRLSCCLAML LSSLLCNIMF FNLNRQEQTE SRERKYMRSM MIGIESVLIT
IPVQLLITFL FTYSQRKPQA DLKEVSPQKH PLMSEASEHW EEGLRKWHAY ETAKAHPREV
AKPASKGKPR LPKASPKATS KPKRRHRKAQ IKTPETPRPN TNSSNNIEDN QDVHSEEHPS
QQDLQQLKEK PRIVLPWWCV YVAWFLVFAT SSISSFFIVF YGLTYGYDKS IEWLFASFCS
FCQSVFLVQP SKIILLSGFR TNKLKYCKNL LWSTNYKYTE ISLDGMRMHP EEMQRIHDQI
VRIRGTRMYQ PLTEDEIRIF KRKKRIKRRA LLFLSYILTH FIFLALLLIL IALLRHTDSF
YYNQFIRDRF SMDLANVTKL EDIYRWLNSV LLPLLHNDLN PTFLPESSSK ILGLPLMRQV
RAKSSEKMCL PAEKFVQNSI RREIHCHPKY GIDPEDTKNY SGFWNEVDKQ AIDESTNGFT
YKPQGKQWLY YSYGLLHTYG SGGYALYFFP KQQQFNSTLR LKELQESNWL DEKTWAVVLE
LTTFNPDVNL FCSISVIFEV SQLGVVNTSI SLHSFSLADF DRKTSAEIYL YVAILIFFLA
YIVDEGYIIM QERASYVRSV YNLLNFALKC IFTVLIVLFL RKHFLATGII QFYLSNPEDF
IPFHAVSQVD HIMRIILGFL LFLTILKTLR YSRFFYDVRL AQRAIQAALP GICHMAFVVS
VYFFVYMAFG YLVFGQHEWN YSNLVHSTQT VFSYCVSAFQ NTEFSNNRIL GVLFLSSFML
VMICVLINLF QAVILSAYEE MKQPVYEEPS DEVEAMTYLC RKLRTMFSFL TSQSKAKDEP
EFFTDMLYGQ PEKNSRRYLG LKTRNINGKK MVYLVV
//
