ID A0A0D9UWR3_9ORYZ Unreviewed; 2043 AA.
AC A0A0D9UWR3;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE RecName: Full=E3 ubiquitin-protein ligase {ECO:0000256|RuleBase:RU366018};
DE EC=2.3.2.27 {ECO:0000256|RuleBase:RU366018};
OS Leersia perrieri.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Leersia.
OX NCBI_TaxID=77586 {ECO:0000313|EnsemblPlants:LPERR01G02810.5, ECO:0000313|Proteomes:UP000032180};
RN [1] {ECO:0000313|EnsemblPlants:LPERR01G02810.5, ECO:0000313|Proteomes:UP000032180}
RP NUCLEOTIDE SEQUENCE.
RA Wing R.A.;
RT "Oryza genome evolution.";
RL Submitted (AUG-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblPlants:LPERR01G02810.5, ECO:0000313|Proteomes:UP000032180}
RP NUCLEOTIDE SEQUENCE.
RA Yu Y., Lee S., de Baynast K., Wissotski M., Liu L., Talag J.,
RA Goicoechea J., Angelova A., Jetty R., Kudrna D., Golser W., Rivera L.,
RA Zhang J., Wing R.;
RL Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EnsemblPlants:LPERR01G02810.5}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
CC -!- FUNCTION: Ubiquitin ligase protein which is a component of the N-end
CC rule pathway. Recognizes and binds to proteins bearing specific N-
CC terminal residues that are destabilizing according to the N-end rule,
CC leading to their ubiquitination and subsequent degradation.
CC {ECO:0000256|RuleBase:RU366018}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900,
CC ECO:0000256|RuleBase:RU366018};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|RuleBase:RU366018}.
CC -!- SIMILARITY: Belongs to the UBR1 family. {ECO:0000256|ARBA:ARBA00009750,
CC ECO:0000256|RuleBase:RU366018}.
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DR EnsemblPlants; LPERR01G02810.5; LPERR01G02810.5; LPERR01G02810.
DR Gramene; LPERR01G02810.5; LPERR01G02810.5; LPERR01G02810.
DR HOGENOM; CLU_001801_1_0_1; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000032180; Chromosome 1.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniRule.
DR GO; GO:0071596; P:ubiquitin-dependent protein catabolic process via the N-end rule pathway; IEA:UniProtKB-UniRule.
DR CDD; cd16482; RING-H2_UBR1-like; 1.
DR CDD; cd19673; UBR-box_UBR3; 1.
DR Gene3D; 2.10.110.30; -; 1.
DR Gene3D; 1.10.10.2670; E3 ubiquitin-protein ligase; 1.
DR InterPro; IPR042065; E3_ELL-like.
DR InterPro; IPR044046; E3_ligase_UBR-like_C.
DR InterPro; IPR039164; UBR1-like.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR003126; Znf_UBR.
DR PANTHER; PTHR21497:SF53; E3 UBIQUITIN-PROTEIN LIGASE PRT6; 1.
DR PANTHER; PTHR21497; UBIQUITIN LIGASE E3 ALPHA-RELATED; 1.
DR Pfam; PF18995; PRT6_C; 1.
DR Pfam; PF02207; zf-UBR; 1.
DR SMART; SM00396; ZnF_UBR1; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51157; ZF_UBR; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU366018};
KW Reference proteome {ECO:0000313|Proteomes:UP000032180};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU366018};
KW Ubl conjugation pathway {ECO:0000256|RuleBase:RU366018};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU366018};
KW Zinc-finger {ECO:0000256|RuleBase:RU366018}.
FT DOMAIN 120..190
FT /note="UBR-type"
FT /evidence="ECO:0000259|PROSITE:PS51157"
FT ZN_FING 120..190
FT /note="UBR-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00508"
FT REGION 1190..1214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2043 AA; 228133 MW; 046EAAA19224974B CRC64;
MAGMDAGGGP SDAAPELSPQ ERVEQKLILF GVPQVHLQEH QEGLLEYLEE HKEQTTEIAK
LILSAFTDLL EARKASNKDG DSSSSEACDE ILSWLQWLMF NNEPHAMLDH LERKSAGERA
VCGSVWGQND LAYRCRTCEH DPTCAICVPC FQNGNHKDHD YSIMYTGGGC CDCGDATAWK
RDGFCSRHKG AEQIKPLPEE LASSVGPVLD VLLQFWKERI CLVEGLPHAE GDGGSSCKRV
AEELTNCAAT MLLEFCTCSE SLLSFVSQRI RECPDLLDAL TRAERLLDKK AIKKLHELLL
KLISEPAFKY EFAKVFIHYY PVTFGEVIKG CNDSQLEEYP LMPTFSVQIF TVPTLTPRLV
REVNLLGVLL GCLTDLFLSC IGDDGRLQTN KWTNLYDATV RLLEDTRYVL SHEEVSKYVA
YERPDLTRSW IKLLSLVQGM DPQKRVTSIH AEDENENLSA PFVLGHYFGI CHGSLVKGAF
SPPEHHESTD VTVCSTATKG MESDENQRHA KVGRVSQNSL ACNLGSKDNS SGALPPPAAW
LILQCLKAIE SWLAPGIALR DKLSSLDASS SDPHNFMALL EKPLTSNKGR VNTNIVEVDA
KINDESQSGV IADNPESFSS SAQDPDNLMQ IDQTGLPHSS NMAGKRKMHE SSSVADAQLH
PDNAISHTLT DGSLLYTPPD SRIEELGILS TVGWPHVVFD VSSQETSFHI PLHRMLSFLL
RKAMEKCFGE DAKPEHCSVQ TNAFFSQALR GCDPFGFASI VMEHPLRLRV FCAQVRAGMW
RKNGDAAILS AEWYRSVQWL EQGLESDLFL LQCCAALSSP EFFVKTIQER FGLSNYTSLD
LSEQNEYESV LMQEMLIFLI QLVKERRFCG LSTSDNLKRE LIYKLAVVDS THSQIVKSLP
RALSSSDQLQ NVLDSLAVYS NPSGMKQGKY VLRKSFWKEL DLYHPRWNSR ELQIAEERYY
RFCKISALNA QLPQWTHVYS PLHSISKIAT SKAVLQIVRS VLFYAVYSDP LSVSRAPDNV
LVTGLHLLWL ALDICESESK TYANQHGMDI VQHDDESWVV LSSYAEEAFP ILTYSTELVA
PVSGKVMNES VLTLLVSLMH KYKEDNDISF SGSKYCNIPS LIESLLKKFA NLSKECMSAI
RQMAPHIVMS MPQHTSGKQN LGSSDSMEKK EKARQRQAAI MAKMRAEQSK FAESMKSSGS
EGHDVPMSEP DVSCSTGVVS EESLPVCSLC RDTDSKSPLC YLVLLQKSRL ATFVEMGNPS
WENLTQSKKI SGSIRREEST DPSGAASCSS EELIADTAVE PSFDSDAMEV DAFLDFSNEQ
HPLIRYISSL PSVYSTSNAG DITSLETIED DVYKTILDHL FGSSNEETKE NEQTLYTSNL
SIGSKKNRSP RSSVLGTYVN CLSKKHHPSL FDVPSKSSAS VTRNRFGPVD CDGIHISSCG
HAVHQECHDR YLFSLKQRYV RRLGFESGHI VDPDLGELLC PLCRRFANSI LPASPDFSSK
HSRKTMPSVQ IPSEGPPASS WVTISNLQFP RALSLLESAG KIVGQTKFLK ALSGKVNNTT
EPSLDPSLRR LSMLYYPRSH NSFSASERLN PSLFLWDTLR YSVVSTEIAS RGRMTSYSES
KSCIGSLRHE LNSSNGFILS LLFRVAHSAR NLNRLEVLLR FEGIHLLAGS ICSGISGDKD
LRNATKRKGT LPPMVDPTSE GGAFPDVQFW KQCADPVLAQ DPFSSLLSTL FCLPVQFLMS
AEFFIPFVHL FYIVCVVQAL ITCYGEETFD RSSFSNCLLN DVCQTMSTYD IAREYFVSKH
IDPSCDPKDM VRRLTYPYLR RCALIWELLK SSSSAPLYDS SNIWEGSHLY LNNSATDSLA
VELNGIRELE DLFQIQSLDP ILQDESVHML ALKWSQHFCE DYKTRKFRGV HFSTPAVPFR
LMELPPVYQV LLERYVKMQC PDCCSVPDEP ALCLLCGKLC SPSWKPCCRT GKCLSHAAQC
GAGVGIFLLV RKTTILLQRS VRLAFWPSPY LDAFGEEDHD MNRGKPLYLS HERYAALTYL
DRS
//
