ID A0A0E0BRK5_9ORYZ Unreviewed; 816 AA.
AC A0A0E0BRK5;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 24-JAN-2024, entry version 28.
DE RecName: Full=Telomerase reverse transcriptase {ECO:0000256|RuleBase:RU365061};
DE EC=2.7.7.49 {ECO:0000256|RuleBase:RU365061};
DE AltName: Full=Telomerase catalytic subunit {ECO:0000256|RuleBase:RU365061};
OS Oryza glumipatula.
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza.
OX NCBI_TaxID=40148 {ECO:0000313|EnsemblPlants:OGLUM12G10420.5};
RN [1] {ECO:0000313|EnsemblPlants:OGLUM12G10420.5}
RP NUCLEOTIDE SEQUENCE.
RA Wing R.A., Panaud O., Oliveira A.C.;
RT "Oryza genome evolution.";
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblPlants:OGLUM12G10420.5}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
CC -!- FUNCTION: Telomerase is a ribonucleoprotein enzyme essential for the
CC replication of chromosome termini in most eukaryotes. It elongates
CC telomeres. It is a reverse transcriptase that adds simple sequence
CC repeats to chromosome ends by copying a template sequence within the
CC RNA component of the enzyme. {ECO:0000256|RuleBase:RU365061}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.49;
CC Evidence={ECO:0000256|RuleBase:RU365061};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU365061}.
CC Chromosome, telomere {ECO:0000256|RuleBase:RU365061}.
CC -!- SIMILARITY: Belongs to the reverse transcriptase family. Telomerase
CC subfamily. {ECO:0000256|RuleBase:RU365061}.
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DR AlphaFoldDB; A0A0E0BRK5; -.
DR EnsemblPlants; OGLUM12G10420.5; OGLUM12G10420.5; OGLUM12G10420.
DR Gramene; OGLUM12G10420.5; OGLUM12G10420.5; OGLUM12G10420.
DR HOGENOM; CLU_001996_1_1_1; -.
DR Proteomes; UP000026961; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003721; F:telomerase RNA reverse transcriptase activity; IEA:InterPro.
DR CDD; cd01648; TERT; 1.
DR Gene3D; 1.10.132.70; -; 2.
DR Gene3D; 1.10.357.90; -; 1.
DR Gene3D; 3.30.70.2630; -; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR003545; Telomerase_RT.
DR InterPro; IPR049139; TERT_C.
DR PANTHER; PTHR12066; TELOMERASE REVERSE TRANSCRIPTASE; 1.
DR PANTHER; PTHR12066:SF0; TELOMERASE REVERSE TRANSCRIPTASE; 1.
DR Pfam; PF00078; RVT_1; 1.
DR Pfam; PF21399; TERT_C; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|RuleBase:RU365061};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU365061};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU365061};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU365061}; Nucleus {ECO:0000256|RuleBase:RU365061};
KW Reference proteome {ECO:0000313|Proteomes:UP000026961};
KW RNA-directed DNA polymerase {ECO:0000256|RuleBase:RU365061};
KW Telomere {ECO:0000256|RuleBase:RU365061};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365061}.
FT DOMAIN 351..624
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 816 AA; 94645 MW; 6A68A6F119EA930C CRC64;
MPRRRRRRAA PGGQVPPELR LAYGARALTL GRAVFSLLPS PRHRESPCPA CRGRVASGCL
ACRRWEHLLR DGDPVAYRRL ITRAVCAIAA DDLSAPPPPR YTPGNSGHSQ ARLVREMMKS
IVADQSHGTK NVLCNGLHEG GQSICISDLV SSSSWSILLH RIGDLLMCYL LRSLVFHSMW
FCEILYLQVL LRENINPKLQ KQNVIQCCWL PKSIKNLIRN SKRCQYKKLF LKHCSVKCKV
APDVTKNDGK AHYPPGGKAA YYDRSFSRLE AYSTHQQVAS FVWAVLKRIV PKPLLGNSFG
KRSLRTNIWK FIKLQRESKR YDVFYYPKSV WRDLTSNAIA SLNKKNFRIL RGEPRKAVRH
LNCSSRVRFL PKAKDMRPLV NLRAKSKDAN LNKCHLIMKK LRDEKPEMFG SSVFDYNNVH
QNLSQFISSK RSQLMKKLKA FDCVSHDMVL KMIDDAFKCD EYTVRKCSKG TICRILKEQF
HHLLYEQIKC NILKIGQKYY LQQVGIAQGS KLSPNLCSLY YGHLENSVLS KFLHDSKLNA
GEAFSEPEYL LMRFIDDFIF ISFSLEHAQK FLNRMRRGFV FYNCYMNDSK YGFNFCAGNS
EPSSNRLYRG DDGVSFMPWS GLLINCETLE IQADYTRYLD ITIISTITVK MHSSTKYIHS
KLCHYMRPKC HPIFYDSNIN SPGTIRVNIY QAFLLCAMKF HCYIRSISDA NVSKLELLQV
IKRTFRYMHS LIVRRMQDVE LHYNVRPVLK LRRKETIWLG LTAYIRVLQQ KQSRYKDMLT
LLTAELGRYC HLGHECDTLR YAVDDSHSSM FWKFKF
//
