ID   A0A0E0ETK7_9ORYZ        Unreviewed;      1505 AA.
AC   A0A0E0ETK7;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=NAD-dependent epimerase/dehydratase domain-containing protein {ECO:0008006|Google:ProtNLM};
OS   Oryza meridionalis.
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza.
OX   NCBI_TaxID=40149 {ECO:0000313|EnsemblPlants:OMERI09G11590.2};
RN   [1] {ECO:0000313|EnsemblPlants:OMERI09G11590.2}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=OR44 {ECO:0000313|EnsemblPlants:OMERI09G11590.2};
RA   Wing R.A., Panaud O., Henry R.;
RL   Submitted (DEC-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblPlants:OMERI09G11590.2}
RP   IDENTIFICATION.
RG   EnsemblPlants;
RL   Submitted (APR-2015) to UniProtKB.
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DR   EnsemblPlants; OMERI09G11590.2; OMERI09G11590.2; OMERI09G11590.
DR   Gramene; OMERI09G11590.2; OMERI09G11590.2; OMERI09G11590.
DR   eggNOG; KOG1502; Eukaryota.
DR   HOGENOM; CLU_002480_0_0_1; -.
DR   Proteomes; UP000008021; Chromosome 9.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   CDD; cd08958; FR_SDR_e; 2.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 7.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR016040; NAD(P)-bd_dom.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR10366; NAD DEPENDENT EPIMERASE/DEHYDRATASE; 1.
DR   PANTHER; PTHR10366:SF500; OS09G0491852 PROTEIN; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   Pfam; PF01370; Epimerase; 3.
DR   Pfam; PF16363; GDP_Man_Dehyd; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 5.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008021}.
FT   DOMAIN          11..191
FT                   /note="NAD-dependent epimerase/dehydratase"
FT                   /evidence="ECO:0000259|Pfam:PF01370"
FT   DOMAIN          340..407
FT                   /note="NAD(P)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF16363"
FT   DOMAIN          641..723
FT                   /note="NAD-dependent epimerase/dehydratase"
FT                   /evidence="ECO:0000259|Pfam:PF01370"
FT   DOMAIN          900..1134
FT                   /note="NAD-dependent epimerase/dehydratase"
FT                   /evidence="ECO:0000259|Pfam:PF01370"
FT   DOMAIN          1278..1371
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
SQ   SEQUENCE   1505 AA;  167628 MW;  E3B46395CEB68FE5 CRC64;
     MTPPPPRRRV VCVTGAGGFV GSWLVELLLS RGYAVHATVR DPDDPKNAFL KQLENAPDNL
     QLFKADVLDC GSLTAAFAGC EGVFHLATPV PEEKIKEMMA PTVEGTRNVL EACSAASVQK
     LVVVSSIATV CLNPSWPQDM PKDESSWSDK KLCIENEDWY SVAKIEAEEM ALEYGKKNGL
     HTVEINTSNK ALLYMIKGGD GPYVMNNNLW PMVDVRDVAD ALLLAYHKAG PSERYLCTLE
     QMDLKHLLDL MKNMYPNYNY ADKMVDVDYK VEVTSEKLKN LGWNPRKREE TLADSIKFFE
     KAGLLDGRPC RLPYFAGARF QSDHSGKVQP EMPPPPRVCV TGAGGFIGSW LVKLLLSRGY
     FVHGTVRNPD DPKNAFLKQL ENATENLQLF KADVLDGGSL TAAFAGCEGV FHPATPVPEQ
     QMKLVVVSSI SAVFANPSWT HDRPKDETSW SDKKLCMETE NWYSLAKTEG EEMALEYGNK
     NGLHVVTTLQ LNTTTKALLY IIQGGHGPDI MNNKFWSMVD VRDVADALLL AYEEAGPSER
     YICALEQMDL KDLLSLMKTM YPNYNYVDKM VDLDYKAEVT SEKLKNLGWN PRKREETFAD
     SIEFFEKAGL LDGQPCRLPY LYLYRFTRNM AAMASPPLRR VCVTGAGGFT GSWLVKLLLS
     RGYAVHATLR DPCDPKNAHL KQLDGASEML SLFKADVLDS GELAAAIAGC EGVFHVASPV
     PGDKIVDPEV QKVVVVSSTA AVHYNPNWPP GKPKDESCWS DRKICMEKEE WYSASKVIAE
     KTALEYSEKK GGPNVMRNML LHIVDVRDVA EALLLVYEKP ESSGRYLCAP YHISPKATVE
     FLKNIYPNYN YSLGWKPRKL EETLTDSIEY YEKTGILQDA AGRPCMTPPP PPPPPPRRLV
     CVTGAGGFIG SWLVKLLLSR GYAVHATVRD PHDPKNAFLK QLEDAPENLR LFKADVLDAG
     SLTAAFAGCE GVFHPATPVP EHKTKEMLDP AVKGTRNVLE ACSAASVQKL VVVSSIGAVC
     FNPSLPRDRL IDETCWSDKK SCKENENWYC LAKTEAEEMA LEYSEKNGLH VITVCPALVL
     GPLLQTVLLS TSSKVLLYVM KGGPDAIGNT FFPIVDVRDV ADALLLVYDK AGPSERYICS
     QEQMDTKDFL DLMKSMYPNY SYTFKVVDVD MRIGLTSEKL KKLGWKPRKL EETLVDSVES
     YKKAGFVDDE PCRLPHLCRA PDAQEAGRRR ETRRPPEMTP RRVCVAGAGA GGFVGSWLVK
     LLLSRGYAVH ATEMIVPAVK GTKNVLEACS ASGVQKLVMI SSIGAVCFNP SWPQDRVRDE
     TCWSDKEFCR ENKNWYCLAK TEAEEIALEY SEKNGLHVIT VCPALVFGPL LHTMQLNTSS
     RVLLYIMKGG PDVMNNKFWP IVDVRDCMTQ SGPCERYICA QDQMNMKDLV DLMKSTYPNY
     SYSFKLVDVG NKVELTSEKP KKLGWKPRKL EETLADSVES FKKAGLVDDE PCRLPHVYRM
     PDTQE
//