ID A0A0E0FPW0_ORYNI Unreviewed; 342 AA.
AC A0A0E0FPW0;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=Flavanone 4-reductase {ECO:0000256|ARBA:ARBA00042087};
DE EC=1.1.1.219 {ECO:0000256|ARBA:ARBA00039057};
DE EC=1.1.1.234 {ECO:0000256|ARBA:ARBA00039055};
OS Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza.
OX NCBI_TaxID=4536 {ECO:0000313|EnsemblPlants:ONIVA01G26720.1};
RN [1] {ECO:0000313|EnsemblPlants:ONIVA01G26720.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SL10 {ECO:0000313|EnsemblPlants:ONIVA01G26720.1};
RA Wing R.A., Hsing Y.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblPlants:ONIVA01G26720.1}
RP IDENTIFICATION.
RC STRAIN=SL10 {ECO:0000313|EnsemblPlants:ONIVA01G26720.1};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(2S)-flavan-4-ol + NADP(+) = (2S)-flavanone + H(+) + NADPH;
CC Xref=Rhea:RHEA:11228, ChEBI:CHEBI:15378, ChEBI:CHEBI:15605,
CC ChEBI:CHEBI:15606, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349;
CC EC=1.1.1.234; Evidence={ECO:0000256|ARBA:ARBA00036737};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a (2R,3S,4S)-leucoanthocyanidin + NADP(+) = a (2R,3R)-
CC dihydroflavonol + H(+) + NADPH; Xref=Rhea:RHEA:54444,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349,
CC ChEBI:CHEBI:138176, ChEBI:CHEBI:138188; EC=1.1.1.219;
CC Evidence={ECO:0000256|ARBA:ARBA00036368};
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DR AlphaFoldDB; A0A0E0FPW0; -.
DR STRING; 4536.A0A0E0FPW0; -.
DR EnsemblPlants; ONIVA01G26720.1; ONIVA01G26720.1; ONIVA01G26720.
DR Gramene; ONIVA01G26720.1; ONIVA01G26720.1; ONIVA01G26720.
DR eggNOG; KOG1502; Eukaryota.
DR HOGENOM; CLU_007383_9_0_1; -.
DR OMA; KERLTLW; -.
DR Proteomes; UP000006591; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0009813; P:flavonoid biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd08958; FR_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR001509; Epimerase_deHydtase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10366:SF613; DIHYDROFLAVONOL 4-REDUCTASE; 1.
DR PANTHER; PTHR10366; NAD DEPENDENT EPIMERASE/DEHYDRATASE; 1.
DR Pfam; PF01370; Epimerase; 2.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Flavonoid biosynthesis {ECO:0000256|ARBA:ARBA00023241};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000006591}.
FT DOMAIN 9..131
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
FT DOMAIN 132..218
FT /note="NAD-dependent epimerase/dehydratase"
FT /evidence="ECO:0000259|Pfam:PF01370"
FT REGION 295..342
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 342 AA; 36680 MW; 4A45CC61EA1E2CBE CRC64;
MGEAVKGPVV VTGASGFVGS WLVMKLLQAG YTVRATVRDP SNVGKTKPLL ELAGSKERLT
LWKADLGEEG SFDAAIRGCT GVFHVATPMD FESEDPENEV IKPTVEGMLS IMRACRDAGT
VKRIVFTSSA GTMYFVSKSL AEKAAMEYAR EHGLDLISVI PTLVVGPFIS NGMPPSHVTA
LALLTGNEAH YSILKQVQFV HLDDLCDAEI FLFESPEARG RYVCSSHDAT IHGLATMLAD
MFPEYDVPRS FPGIDADHLQ PVHFSSWKLL AHGFRFRYTL EDMFEAAVRT CREKGLLPPL
PPPPTTAVAG GDGSAGVAGE KEPILGRGTG TAVGAETEAL VK
//
