ID A0A0E0G4U4_ORYNI Unreviewed; 1596 AA.
AC A0A0E0G4U4;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE RecName: Full=Uridine kinase {ECO:0000256|RuleBase:RU003825};
DE EC=2.7.1.48 {ECO:0000256|RuleBase:RU003825};
OS Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza.
OX NCBI_TaxID=4536 {ECO:0000313|EnsemblPlants:ONIVA02G13310.3};
RN [1] {ECO:0000313|EnsemblPlants:ONIVA02G13310.3}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SL10 {ECO:0000313|EnsemblPlants:ONIVA02G13310.3};
RA Wing R.A., Hsing Y.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblPlants:ONIVA02G13310.3}
RP IDENTIFICATION.
RC STRAIN=SL10 {ECO:0000313|EnsemblPlants:ONIVA02G13310.3};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + cytidine = ADP + CMP + H(+); Xref=Rhea:RHEA:24674,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17562, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:60377, ChEBI:CHEBI:456216; EC=2.7.1.48;
CC Evidence={ECO:0000256|RuleBase:RU003825};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + uridine = ADP + H(+) + UMP; Xref=Rhea:RHEA:16825,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:16704, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57865, ChEBI:CHEBI:456216; EC=2.7.1.48;
CC Evidence={ECO:0000256|RuleBase:RU003825};
CC -!- PATHWAY: Pyrimidine metabolism; CTP biosynthesis via salvage pathway;
CC CTP from cytidine: step 1/3. {ECO:0000256|RuleBase:RU003825}.
CC -!- PATHWAY: Pyrimidine metabolism; UMP biosynthesis via salvage pathway;
CC UMP from uridine: step 1/1. {ECO:0000256|ARBA:ARBA00004690,
CC ECO:0000256|RuleBase:RU003825}.
CC -!- SIMILARITY: Belongs to the disease resistance NB-LRR family.
CC {ECO:0000256|ARBA:ARBA00008894}.
CC -!- SIMILARITY: Belongs to the uridine kinase family.
CC {ECO:0000256|RuleBase:RU003825}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the UPRTase family.
CC {ECO:0000256|ARBA:ARBA00010723}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the uridine kinase
CC family. {ECO:0000256|ARBA:ARBA00008173}.
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DR STRING; 4536.A0A0E0G4U4; -.
DR EnsemblPlants; ONIVA02G13310.3; ONIVA02G13310.3; ONIVA02G13310.
DR Gramene; ONIVA02G13310.3; ONIVA02G13310.3; ONIVA02G13310.
DR eggNOG; KOG4203; Eukaryota.
DR eggNOG; KOG4658; Eukaryota.
DR HOGENOM; CLU_003562_0_0_1; -.
DR UniPathway; UPA00574; UER00637.
DR UniPathway; UPA00579; UER00640.
DR Proteomes; UP000006591; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0043771; F:cytidine kinase activity; IEA:RHEA.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004845; F:uracil phosphoribosyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0004849; F:uridine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0044211; P:CTP salvage; IEA:UniProtKB-UniPathway.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR GO; GO:0044206; P:UMP salvage; IEA:UniProtKB-UniPathway.
DR CDD; cd06223; PRTases_typeI; 1.
DR CDD; cd14798; RX-CC_like; 1.
DR CDD; cd02023; UMPK; 1.
DR Gene3D; 1.20.5.4130; -; 1.
DR Gene3D; 3.40.50.2020; -; 1.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000836; PRibTrfase_dom.
DR InterPro; IPR006083; PRK/URK.
DR InterPro; IPR029057; PRTase-like.
DR InterPro; IPR038005; RX-like_CC.
DR InterPro; IPR041118; Rx_N.
DR InterPro; IPR000764; Uridine_kinase-like.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR NCBIfam; TIGR00235; udk; 1.
DR PANTHER; PTHR23155; DISEASE RESISTANCE PROTEIN RP; 1.
DR PANTHER; PTHR23155:SF1137; NB-ARC DOMAIN CONTAINING PROTEIN, EXPRESSED; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF00485; PRK; 1.
DR Pfam; PF18052; Rx_N; 1.
DR Pfam; PF14681; UPRTase; 1.
DR PRINTS; PR00988; URIDINKINASE.
DR SUPFAM; SSF52058; L domain-like; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR SUPFAM; SSF53271; PRTase-like; 1.
PE 3: Inferred from homology;
KW Allosteric enzyme {ECO:0000256|ARBA:ARBA00022533};
KW ATP-binding {ECO:0000256|RuleBase:RU003825};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Glycosyltransferase {ECO:0000256|ARBA:ARBA00022676};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Kinase {ECO:0000256|RuleBase:RU003825};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU003825};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000006591};
KW Transferase {ECO:0000256|RuleBase:RU003825}.
FT DOMAIN 181..367
FT /note="Phosphoribulokinase/uridine kinase"
FT /evidence="ECO:0000259|Pfam:PF00485"
FT DOMAIN 646..716
FT /note="Disease resistance N-terminal"
FT /evidence="ECO:0000259|Pfam:PF18052"
FT DOMAIN 794..1031
FT /note="NB-ARC"
FT /evidence="ECO:0000259|Pfam:PF00931"
FT REGION 1..50
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1526..1558
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 735..762
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1543..1558
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1596 AA; 179024 MW; 01EBF9C465C8D162 CRC64;
MDKRPNPRNI DKPNFLEMPS IPPGKKGSKK DGISSAWVSR RRPRLLPPPL PPTLSLSPLS
SLSPPPTRQP LSLSLLSHFV PLPLPSPSVP RICRHRGWAR FWLISPSQLL AAAAISVRGF
APRFLEQYMG SRPVDEVLDA AAAGVHYSTL RLDELNINGS MTGEEQPTTS GVENGHQEPF
VIGVAGGASS GKSTVCKMII DQLRDQRVVV VTQESFYYGL SDEELVHVHD YNFDHPDAFD
TELLLSCMEN LKHGKAVDIP NYNFKTYKSV ASARKVNPSD VIILEGILVF HDSRVRDLMN
MKIFVDTDAD VRLTRRIRRD TIEKGRDIKT VLDQYSKFVK PAFEDFILPT KKYADIIIPR
GGDNDVAIDL IVQHIRTKLG QHDLCKVHPN LYVIQTTYQI RGMHTIIRDA ATTTHDFIFY
ADRLIRLVVE HGLGHLPFKE KQVITPTGSV YTGVEFSKRL CGISVIRSGE SMENALRACC
KGIKIGKILI HREGDNGKQL IYHNLPKDIA NRHVLLLDPI LGTGNSAVQA ISLLLKKGVQ
ETNIIFLNLI SAPQGVHVVS KRFPRVKIVT SEIEFGLNDD FRVIPGMGEF GDRYFGTDDY
QSSTPFFCDE KNRVSSRARD GWCGGERFLR GDELRHSQAG FLAHRREYTH LKGVKSGIRW
LRDELGSMNA VLQRLGDMDD DQIDVQTKEW RNKVRELSYD IEDCIDRFLQ NHSSGDANAN
LLQKGVRKMK KLWENHQIGD EIKQLKERVI EEKERHERYK IADRLMVAPQ HVRLDPRVPA
LYEQAKNLVG IDKPREQIIG WIKSEEKQLK VVSIFGTGGL GKTTLAMDVY HKIDESFDCR
AMVSVSRTPD IKKLLRDILF QINEREYEKS NDWEMEQLIP KLRKNLEDKR YFFIIDDIWS
TDAWKQLKSA LPANDNKSRI ITTTRIRDVA KSCCCDFVGH MYEAMPQSEE NSCKLFFRRV
FSSEDCPKHL TEAASVILKK CGGLPLAIIS IAGLLSNKNP TVEVWTKIKN SISSMKDSPV
DKMKRILFLS YFDLPQYLKT CLLYLSVFPE DSNIDPRRLI RLWVAEGLIL GQSRACTEQS
GESYLHELIN RSMIQPSKIG ADGRVKICRI HDVILDFIVS QAEEENFVTI LNNSDPSDYT
SNKFRRLSLQ SGFSEGSKMP KASKDLSHLR SLHMFKHESL PVVPSEFAKC QVLRVLAINF
VWGTTILNML DIFYLRIKGG IHKLPEQIGK LQHLQTLDLA YTRIEKLPAS IVQLQKLVHL
LIPFGVPLPD EIGNLQALEV LSGIDLDRAS VKSIYGLGEL SKLRDVRIWW SDSNEDNSKE
GHRTACISSL SKLVKCSLQS LRLARGLSNP DVIASLMISC GFIPPLRRLV FYDEFPTIPS
QFASLVNLTR LRVEVGGVGG LEILASLPIL QSLTLDTNSD VSNLRWVISG QGFQNLRKFN
FEIRDSVVGL MFEPGAMPKL QRLKLWLYAR WQLDVHGGPV VGLHHLSALK SIALVFNCNG
AVAAEVESSE DDARAAAHCI VSEQAVASGT PPAPPPHPTP PAIRMTTTGN GGGGTTPNPT
GVAPATLPLT HMKVAVLALT ASSLARTLLA MSPSIN
//
