ID A0A0E0GHA1_ORYNI Unreviewed; 669 AA.
AC A0A0E0GHA1;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=procollagen-proline 4-dioxygenase {ECO:0000256|ARBA:ARBA00012269};
DE EC=1.14.11.2 {ECO:0000256|ARBA:ARBA00012269};
OS Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza.
OX NCBI_TaxID=4536 {ECO:0000313|EnsemblPlants:ONIVA03G04730.2};
RN [1] {ECO:0000313|EnsemblPlants:ONIVA03G04730.2}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SL10 {ECO:0000313|EnsemblPlants:ONIVA03G04730.2};
RA Wing R.A., Hsing Y.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblPlants:ONIVA03G04730.2}
RP IDENTIFICATION.
RC STRAIN=SL10 {ECO:0000313|EnsemblPlants:ONIVA03G04730.2};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=2-oxoglutarate + L-prolyl-[collagen] + O2 = CO2 + succinate +
CC trans-4-hydroxy-L-prolyl-[collagen]; Xref=Rhea:RHEA:18945, Rhea:RHEA-
CC COMP:11676, Rhea:RHEA-COMP:11680, ChEBI:CHEBI:15379,
CC ChEBI:CHEBI:16526, ChEBI:CHEBI:16810, ChEBI:CHEBI:30031,
CC ChEBI:CHEBI:50342, ChEBI:CHEBI:61965; EC=1.14.11.2;
CC Evidence={ECO:0000256|ARBA:ARBA00024151};
CC -!- COFACTOR:
CC Name=L-ascorbate; Xref=ChEBI:CHEBI:38290;
CC Evidence={ECO:0000256|ARBA:ARBA00001961};
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004648}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004648}. Membrane
CC {ECO:0000256|ARBA:ARBA00004606}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00004606}.
CC -!- SIMILARITY: Belongs to the P4HA family.
CC {ECO:0000256|ARBA:ARBA00006511}.
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DR AlphaFoldDB; A0A0E0GHA1; -.
DR STRING; 4536.A0A0E0GHA1; -.
DR EnsemblPlants; ONIVA03G04730.2; ONIVA03G04730.2; ONIVA03G04730.
DR Gramene; ONIVA03G04730.2; ONIVA03G04730.2; ONIVA03G04730.
DR eggNOG; KOG1591; Eukaryota.
DR HOGENOM; CLU_450861_0_0_1; -.
DR OMA; WTMLPTG; -.
DR Proteomes; UP000006591; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR GO; GO:0031418; F:L-ascorbic acid binding; IEA:InterPro.
DR GO; GO:0004656; F:procollagen-proline 4-dioxygenase activity; IEA:UniProtKB-EC.
DR Gene3D; 2.60.120.620; q2cbj1_9rhob like domain; 2.
DR InterPro; IPR005123; Oxoglu/Fe-dep_dioxygenase.
DR InterPro; IPR045054; P4HA-like.
DR InterPro; IPR006620; Pro_4_hyd_alph.
DR InterPro; IPR044862; Pro_4_hyd_alph_FE2OG_OXY.
DR InterPro; IPR003582; ShKT_dom.
DR PANTHER; PTHR10869:SF219; OS03G0166100 PROTEIN; 1.
DR PANTHER; PTHR10869; PROLYL 4-HYDROXYLASE ALPHA SUBUNIT; 1.
DR Pfam; PF13640; 2OG-FeII_Oxy_3; 2.
DR Pfam; PF01549; ShK; 2.
DR SMART; SM00702; P4Hc; 2.
DR SMART; SM00254; ShKT; 2.
DR PROSITE; PS51471; FE2OG_OXY; 2.
PE 3: Inferred from homology;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Iron {ECO:0000256|ARBA:ARBA00023004}; Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000006591};
KW Signal {ECO:0000256|SAM:SignalP};
KW Signal-anchor {ECO:0000256|ARBA:ARBA00022968};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..669
FT /note="procollagen-proline 4-dioxygenase"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5002360518"
FT TRANSMEM 116..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..349
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 143..265
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
FT DOMAIN 491..613
FT /note="Fe2OG dioxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51471"
SQ SEQUENCE 669 AA; 73258 MW; 907584160B2D8D29 CRC64;
MARLVLLAVL PLLLLFVAGD SYATAAGGGG GGGGRRFDAS RAVDVSWRPR AFLYEGFLSD
AECDHLISLA KQGKMEKSTV VDGESGESVT SKVRTSSGMF LDKKQDEVVA RIEERIAAWT
MLPTECIIFY CFANFAILKL SENGESMQIL RYGQGEKYEP HFDYISGRQG STREGDRVAT
VLMYLSNVKM GGETIFPDCE ARLSQPKDET WSDCAEQGFA VKPAKGSAVL FFSLHPNATL
DTDSLHGSCP VIEGEKWSAT KWIHVRSYSY RRRSAGKCED EHVLCSSWAA AGECAKNPGY
MVGTSDSPPG FCRKSCNAGG ARLCRRRRRT GMARLVLLVA LLLLLSVTGE TSATGGGGEG
GRFDASRAVD VSWSPRVFLY EGFLSDAECE HLIALAKQGR MERSTVVNGK SGESVMSKTR
TSSGMFLIRK QDEVVARIEE RIAAWTMFPA GMVQGHRTLE NCLIGPCSKC SSECITFYCF
ARFVILERSE NGESMQMLRY GQGEKYEPHF DYIRGRQASA RGGHRIATVL MYLSNVKMGG
ETVFPDAEAR LSQPKDETWS DCAEQGFAVK PTKGSAVLFF SLYPNATFDP GSLHGSCPVI
QGEKWSATKW IHVRSYDENG RRSSDKCEDE HALCSSWAAA GECAKNPGYM VGTSESPGFC
RKSCNVCTS
//
