UniProt: A0A0E0GUZ4

Database: UniProt
Entry: A0A0E0GUZ4_ORYNI

LinkDB:  A0A0E0GUZ4_ORYNI 
Original site:  A0A0E0GUZ4_ORYNI

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Ontology (5)   
   GO (5)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Protein domain (16)   
   InterPro (8)   
   Pfam (3)   
   PROSITE (4)   
   SMART (1)   
All databases (22)   

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ID   A0A0E0GUZ4_ORYNI        Unreviewed;      1529 AA.
AC   A0A0E0GUZ4;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   24-JAN-2024, entry version 47.
DE   RecName: Full=DNA (cytosine-5)-methyltransferase {ECO:0000256|PIRNR:PIRNR037404};
DE            EC=2.1.1.37 {ECO:0000256|PIRNR:PIRNR037404};
OS   Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza.
OX   NCBI_TaxID=4536 {ECO:0000313|EnsemblPlants:ONIVA03G38820.1};
RN   [1] {ECO:0000313|EnsemblPlants:ONIVA03G38820.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SL10 {ECO:0000313|EnsemblPlants:ONIVA03G38820.1};
RA   Wing R.A., Hsing Y.;
RL   Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblPlants:ONIVA03G38820.1}
RP   IDENTIFICATION.
RC   STRAIN=SL10 {ECO:0000313|EnsemblPlants:ONIVA03G38820.1};
RG   EnsemblPlants;
RL   Submitted (APR-2015) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxycytidine in DNA + S-adenosyl-L-methionine = a 5-
CC         methyl-2'-deoxycytidine in DNA + H(+) + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:13681, Rhea:RHEA-COMP:11369, Rhea:RHEA-COMP:11370,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:85452, ChEBI:CHEBI:85454; EC=2.1.1.37;
CC         Evidence={ECO:0000256|PIRNR:PIRNR037404,
CC         ECO:0000256|RuleBase:RU000417};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|PIRNR:PIRNR037404}.
CC   -!- SIMILARITY: Belongs to the class I-like SAM-binding methyltransferase
CC       superfamily. C5-methyltransferase family.
CC       {ECO:0000256|PIRNR:PIRNR037404, ECO:0000256|PROSITE-ProRule:PRU01016,
CC       ECO:0000256|RuleBase:RU000416}.
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DR   STRING; 4536.A0A0E0GUZ4; -.
DR   EnsemblPlants; ONIVA03G38820.1; ONIVA03G38820.1; ONIVA03G38820.
DR   Gramene; ONIVA03G38820.1; ONIVA03G38820.1; ONIVA03G38820.
DR   eggNOG; ENOG502QPKK; Eukaryota.
DR   OMA; YWPEKGG; -.
DR   Proteomes; UP000006591; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003682; F:chromatin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003886; F:DNA (cytosine-5-)-methyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006346; P:DNA methylation-dependent heterochromatin formation; IEA:EnsemblPlants.
DR   CDD; cd04708; BAH_plantDCM_II; 1.
DR   Gene3D; 2.30.30.490; -; 2.
DR   Gene3D; 3.90.120.10; DNA Methylase, subunit A, domain 2; 2.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR001025; BAH_dom.
DR   InterPro; IPR043151; BAH_sf.
DR   InterPro; IPR018117; C5_DNA_meth_AS.
DR   InterPro; IPR001525; C5_MeTfrase.
DR   InterPro; IPR031303; C5_meth_CS.
DR   InterPro; IPR022702; Cytosine_MeTrfase1_RFD.
DR   InterPro; IPR017198; DNMT1-like.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   NCBIfam; TIGR00675; dcm; 1.
DR   PANTHER; PTHR10629; CYTOSINE-SPECIFIC METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR10629:SF52; DNA (CYTOSINE-5)-METHYLTRANSFERASE 1; 1.
DR   Pfam; PF01426; BAH; 2.
DR   Pfam; PF00145; DNA_methylase; 1.
DR   Pfam; PF12047; DNMT1-RFD; 2.
DR   PIRSF; PIRSF037404; DNMT1; 5.
DR   PRINTS; PR00105; C5METTRFRASE.
DR   SMART; SM00439; BAH; 2.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS51038; BAH; 2.
DR   PROSITE; PS00094; C5_MTASE_1; 1.
DR   PROSITE; PS00095; C5_MTASE_2; 1.
DR   PROSITE; PS51679; SAM_MT_C5; 1.
PE   3: Inferred from homology;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PIRNR:PIRNR037404};
KW   Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW   ECO:0000256|PIRNR:PIRNR037404};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PIRNR:PIRNR037404};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006591};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW   ECO:0000256|PIRNR:PIRNR037404};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|PIRNR:PIRNR037404}.
FT   DOMAIN          722..854
FT                   /note="BAH"
FT                   /evidence="ECO:0000259|PROSITE:PS51038"
FT   DOMAIN          890..1029
FT                   /note="BAH"
FT                   /evidence="ECO:0000259|PROSITE:PS51038"
FT   REGION          1..62
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          641..698
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        17..42
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        649..670
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   ACT_SITE        1177
FT                   /evidence="ECO:0000256|PIRSR:PIRSR037404-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01016"
SQ   SEQUENCE   1529 AA;  171173 MW;  D745FCEC473A2402 CRC64;
     MAKSPRSVVT TGTKRRRAKV HKEDEPVENE NLESEFDVSK KESNGATELG NEPVASKRPK
     RAAACSNFKE KSLDLSEKDS IITIKESRVE EKEIEAVNLT RTGPEDGQPC RKIIDFILHD
     GDGNLQPFEM SEVDDIFITA LIMPLDDDLE KDRGKGIRCS GFGRIENWAI SGYDEGAAVI
     WVSTETSDYK CVKPASSYRS YFEHFSEKAR VCVEVYKKLA RSVGGNPQVD LEELIAGVVR
     SINSNRSFNG TVTKDFVISS GEFIYKQLIG LDHTAGNDDE MLATLPVLVA LKDECKSRAG
     FTHLPAMPSN GTLRIKDGQD KGLTEDEDAK LARLLQEEEE WKMMKQRGKR GTSQKNIYIK
     ICETEIANDY PLPAYYKPYN QEMDEYIFDS DIGMYSDDVP VRILDNWALY NSDSRLISLE
     LIPMKAGAEN DIVVFGSGFM REDDGSCCST AELAQLHSSS SKSGREDPGV PIYLSPIKEY
     KLRQPTKQYA PWCEPVLKTA RLAVSIITLL KEQSRASKLS FAEVIKKVAE FDSRHPAFIS
     SKAPTVERYV VVHGQIILQQ FADFPDESVK RCAFITGLLA KMEESRHTKL AIKKKSQQMR
     GENLNPSAKM GPILRKKLMR ATTTMLISKI WGEYYATYFP GDTKEEDQNE PKEIDDDQEE
     NEDNDAEEEV NVQDEKATRT PPSTRSRKSS ADTRKEIKWE GETAGKTVSG EVLYKCVIVQ
     DLSISVGATV TIEDDSGETI MCFVEYMYEK LDGKNMIHGI ILQEGSQTVL GNAANDREVF
     LTNDCLEFEA SDIKELVTVN IQSLPWGHKY RKENSEAKRI EKAKAEERKR KGLPVEYICK
     SLYWPEKGGF FSLPYDKIGN GTGICSSCER KPVGNEFKLL SESSFVFENI TYNIHDFLYI
     RPEFFSQGEG HETYKAGRNV GLKPYAVCHL LSVHGPAGSR KANPESTKVK VRRFYRPDDI
     SSTKAYSSDI REVYYSEDII SVPVVMIEGK CEVRLKDDLP NSDLPAVVEH VFCCEYLYDP
     ANGALKQLPP NVRLVTLTRK VPASKKNKGK QICDIELGGS DKPKDGQAEN CLATLDIFAG
     CGGLSEGLQR SGLSLTKWAI EYEEPAGDAF GENHPEAAVF VENCNVILKA IMDKCGDSDD
     CISTSEAAER AAKLSEDKIK NLPVPGEVEF INGGPPCQGF SGMNRFNQSP WSKVQCEMIL
     AFLSFAEYFR PRFFLLENVR NFVSFNKGQT FRLTLASLLE MGYQVRFGIL EAGAYGVAQS
     RKRAFIWAAA PGETLPEWPE PMHVFASPEL KITLPDGKFY AAVKSTAAGA PFRSITVRDT
     IGDLPAVENG AGKPTIQYGS GPVSWFQKKI RSDMASLNDH ISKEMNELNL IRCKHIPKRP
     GCDWHDLPDE KVKLSTGQMV DLIPWCLPNT AKRHNQWKGL YGRLDWEGNF PTSVTDPQPM
     GKVGMCFHPE QDRIITVREC ARSQGFPDSY RFAGNIQNKH RQIGNAVPPP LAYALGRKLK
     QAIDAKRKDG WLTVRQADKI FLQSNLKSS
//

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