UniProt: A0A0E0IZ69

Database: UniProt
Entry: A0A0E0IZ69_ORYNI

LinkDB:  A0A0E0IZ69_ORYNI 
Original site:  A0A0E0IZ69_ORYNI

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Ontology (8)   
   GO (8)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Protein domain (15)   
   InterPro (10)   
   Pfam (3)   
   PROSITE (1)   
   SMART (1)   
All databases (24)   

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ID   A0A0E0IZ69_ORYNI        Unreviewed;      1082 AA.
AC   A0A0E0IZ69;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=DNA polymerase {ECO:0000256|RuleBase:RU000442};
DE            EC=2.7.7.7 {ECO:0000256|RuleBase:RU000442};
OS   Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza.
OX   NCBI_TaxID=4536 {ECO:0000313|EnsemblPlants:ONIVA11G05720.1};
RN   [1] {ECO:0000313|EnsemblPlants:ONIVA11G05720.1}
RP   NUCLEOTIDE SEQUENCE.
RC   STRAIN=SL10 {ECO:0000313|EnsemblPlants:ONIVA11G05720.1};
RA   Wing R.A., Hsing Y.;
RL   Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EnsemblPlants:ONIVA11G05720.1}
RP   IDENTIFICATION.
RC   STRAIN=SL10 {ECO:0000313|EnsemblPlants:ONIVA11G05720.1};
RG   EnsemblPlants;
RL   Submitted (APR-2015) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC         diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC         Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC         ChEBI:CHEBI:173112; EC=2.7.7.7;
CC         Evidence={ECO:0000256|ARBA:ARBA00024632,
CC         ECO:0000256|RuleBase:RU000442};
CC   -!- COFACTOR:
CC       Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883;
CC         Evidence={ECO:0000256|ARBA:ARBA00001966,
CC         ECO:0000256|RuleBase:RU000442};
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU000442}.
CC   -!- SIMILARITY: Belongs to the DNA polymerase type-B family.
CC       {ECO:0000256|ARBA:ARBA00005755, ECO:0000256|RuleBase:RU000442}.
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DR   AlphaFoldDB; A0A0E0IZ69; -.
DR   STRING; 4536.A0A0E0IZ69; -.
DR   EnsemblPlants; ONIVA11G05720.1; ONIVA11G05720.1; ONIVA11G05720.
DR   Gramene; ONIVA11G05720.1; ONIVA11G05720.1; ONIVA11G05720.
DR   eggNOG; KOG0969; Eukaryota.
DR   HOGENOM; CLU_000203_2_0_1; -.
DR   OMA; CNNCRPR; -.
DR   Proteomes; UP000006591; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   CDD; cd05777; DNA_polB_delta_exo; 1.
DR   CDD; cd05533; POLBc_delta; 1.
DR   Gene3D; 1.10.132.60; DNA polymerase family B, C-terminal domain; 1.
DR   Gene3D; 3.30.342.10; DNA Polymerase, chain B, domain 1; 1.
DR   Gene3D; 1.10.287.690; Helix hairpin bin; 1.
DR   Gene3D; 3.90.1600.10; Palm domain of DNA polymerase; 1.
DR   Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR   InterPro; IPR006172; DNA-dir_DNA_pol_B.
DR   InterPro; IPR017964; DNA-dir_DNA_pol_B_CS.
DR   InterPro; IPR006133; DNA-dir_DNA_pol_B_exonuc.
DR   InterPro; IPR006134; DNA-dir_DNA_pol_B_multi_dom.
DR   InterPro; IPR043502; DNA/RNA_pol_sf.
DR   InterPro; IPR042087; DNA_pol_B_thumb.
DR   InterPro; IPR023211; DNA_pol_palm_dom_sf.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR036397; RNaseH_sf.
DR   InterPro; IPR025687; Znf-C4pol.
DR   NCBIfam; TIGR00592; pol2; 1.
DR   PANTHER; PTHR10322; DNA POLYMERASE CATALYTIC SUBUNIT; 1.
DR   PANTHER; PTHR10322:SF23; DNA POLYMERASE DELTA CATALYTIC SUBUNIT; 1.
DR   Pfam; PF00136; DNA_pol_B; 1.
DR   Pfam; PF03104; DNA_pol_B_exo1; 1.
DR   Pfam; PF14260; zf-C4pol; 1.
DR   PRINTS; PR00106; DNAPOLB.
DR   SMART; SM00486; POLBc; 1.
DR   SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR   SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR   PROSITE; PS00116; DNA_POLYMERASE_B; 1.
PE   3: Inferred from homology;
KW   4Fe-4S {ECO:0000256|ARBA:ARBA00022485, ECO:0000256|RuleBase:RU000442};
KW   DNA replication {ECO:0000256|RuleBase:RU000442};
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU000442};
KW   DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW   ECO:0000256|RuleBase:RU000442};
KW   Exonuclease {ECO:0000256|ARBA:ARBA00022839};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Iron {ECO:0000256|ARBA:ARBA00023004, ECO:0000256|RuleBase:RU000442};
KW   Iron-sulfur {ECO:0000256|ARBA:ARBA00023014, ECO:0000256|RuleBase:RU000442};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU000442}; Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000256|RuleBase:RU000442};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU000442};
KW   Reference proteome {ECO:0000313|Proteomes:UP000006591};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000442};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU000442};
KW   Zinc-finger {ECO:0000256|RuleBase:RU000442}.
FT   DOMAIN          192..463
FT                   /note="DNA-directed DNA polymerase family B exonuclease"
FT                   /evidence="ECO:0000259|Pfam:PF03104"
FT   DOMAIN          522..955
FT                   /note="DNA-directed DNA polymerase family B
FT                   multifunctional"
FT                   /evidence="ECO:0000259|Pfam:PF00136"
FT   DOMAIN          992..1063
FT                   /note="C4-type zinc-finger of DNA polymerase delta"
FT                   /evidence="ECO:0000259|Pfam:PF14260"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1082 AA;  120956 MW;  9670D7B38636867E CRC64;
     MSSGGRGGKR RGAPPPGPSG AAAKRAHPGG TPQPPPPAAT AAAPVVEEED MMDEDVFLDE
     TILAEDEEAL LLLDRDEALA SRLSRWKRPA LPADLASGCS RNVAFQQLEI DYVIGESHKV
     LLPNSSGPAA ILRIFGVTRE GHSVCCQVHG FEPYFYISCP MGMGPDDISR FHQTLEGRMK
     DSNRNSNVPR FVKRIELVQK QTIMHYQPQQ SQPFLKIVVA LPTMVASCRG ILERGITIEG
     LGSKSFLTYE SNILFALRFM IDCNIVGGNW IEVPAGKYSD LVSHAAEGEH SKMAPFRILS
     FDIECAGRKG HFPEPTHDPV IQIANLVTLQ GEGQPFVRNV MTLKSCSPIV GVDVMSFDTE
     RDVLLAWRDF IREVDPDIII GYNICKFDLP YLIERAEVLK IVEFPILGRI RNSRVRVRDT
     TFSSRQYGMR ESKDVAVEGR VQFDLLQAMQ RDYKLSSYSL NSVSAHFLGE QKEDVHHSII
     SDLQNGNSET RRRLADAYLP QRLLDKLMYI YNYVEMARVT GVPISFLLSR GQSIKVLSQL
     LRKAKQKNLV IPNIKGQASG QDTFEGATVL EARAGFYEKP IATLDFASLY PSIMMAYNLC
     YCTLVPPEDA RKLNLPPESV NKTPSGETFV KPDVQKGILP EILEELLAAR KRAKADLKEA
     KDPFERAVLD GRQLALKISA NSVYGFTGAT VGQLPCLEIS SSVTSYGRQM IEHTKKLVED
     KFTTLGGYEH NAEVIYGDTD SVMVQFGVST VEDAMKLGRE AADYISGTFI KPIKLEFEKI
     YFPYLLISKK RYAGLYWTNP EKFDKMDTKG IETVRRDNCL LVKNLVTECL HKILVDRDVP
     GAVQYVKNTI SDLLMNRVDL SLLVITKGLT KTGEDYAVKA AHVELAERMR KRDAATAPTV
     GDRVPYVIIK AAKGAKAYER SEDPIYVLDN NIPIDPQYYL ENQISKPLLR IFEPILKNAS
     RELLHGSHTR AVSISTPSNS GIMKFAKKQL TCLGCKAVIS GSNQTLCSHC KGREAELYCK
     TVGNVSELEM LFGRLWTQCQ ECQGSLHQDV LCTSRDCPIF YRRRKAQKDM AEARVQLQRW
     DF
//

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