ID A0A0E0J9B3_ORYNI Unreviewed; 728 AA.
AC A0A0E0J9B3;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE RecName: Full=Telomerase reverse transcriptase {ECO:0000256|RuleBase:RU365061};
DE EC=2.7.7.49 {ECO:0000256|RuleBase:RU365061};
DE AltName: Full=Telomerase catalytic subunit {ECO:0000256|RuleBase:RU365061};
OS Oryza nivara (Indian wild rice) (Oryza sativa f. spontanea).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza.
OX NCBI_TaxID=4536 {ECO:0000313|EnsemblPlants:ONIVA12G09220.4};
RN [1] {ECO:0000313|EnsemblPlants:ONIVA12G09220.4}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=SL10 {ECO:0000313|EnsemblPlants:ONIVA12G09220.4};
RA Wing R.A., Hsing Y.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblPlants:ONIVA12G09220.4}
RP IDENTIFICATION.
RC STRAIN=SL10 {ECO:0000313|EnsemblPlants:ONIVA12G09220.4};
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
CC -!- FUNCTION: Telomerase is a ribonucleoprotein enzyme essential for the
CC replication of chromosome termini in most eukaryotes. It elongates
CC telomeres. It is a reverse transcriptase that adds simple sequence
CC repeats to chromosome ends by copying a template sequence within the
CC RNA component of the enzyme. {ECO:0000256|RuleBase:RU365061}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.49;
CC Evidence={ECO:0000256|RuleBase:RU365061};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU365061}.
CC Chromosome, telomere {ECO:0000256|RuleBase:RU365061}.
CC -!- SIMILARITY: Belongs to the reverse transcriptase family. Telomerase
CC subfamily. {ECO:0000256|RuleBase:RU365061}.
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DR AlphaFoldDB; A0A0E0J9B3; -.
DR EnsemblPlants; ONIVA12G09220.4; ONIVA12G09220.4; ONIVA12G09220.
DR Gramene; ONIVA12G09220.4; ONIVA12G09220.4; ONIVA12G09220.
DR Proteomes; UP000006591; Unassembled WGS sequence.
DR GO; GO:0000781; C:chromosome, telomeric region; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0003721; F:telomerase RNA reverse transcriptase activity; IEA:InterPro.
DR CDD; cd01648; TERT; 1.
DR Gene3D; 1.10.132.70; -; 2.
DR Gene3D; 3.30.70.2630; -; 1.
DR InterPro; IPR000477; RT_dom.
DR InterPro; IPR003545; Telomerase_RT.
DR PANTHER; PTHR12066; TELOMERASE REVERSE TRANSCRIPTASE; 1.
DR PANTHER; PTHR12066:SF0; TELOMERASE REVERSE TRANSCRIPTASE; 1.
DR Pfam; PF00078; RVT_1; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Chromosome {ECO:0000256|RuleBase:RU365061};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|RuleBase:RU365061};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU365061};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW ECO:0000256|RuleBase:RU365061}; Nucleus {ECO:0000256|RuleBase:RU365061};
KW Reference proteome {ECO:0000313|Proteomes:UP000006591};
KW RNA-directed DNA polymerase {ECO:0000256|RuleBase:RU365061};
KW Telomere {ECO:0000256|RuleBase:RU365061};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU365061}.
FT DOMAIN 352..625
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
SQ SEQUENCE 728 AA; 84340 MW; 69FA1F42FCBF8BA1 CRC64;
MPRRRRRRRA APGGQVPPEL RLAYGARALT LGRAVFSLLP SPRHCESPCP ACRGRVASGC
LACRRWEHLL RDGDPIAYRR LITRAVCAIA ADDLSAPPPP RYTPGNSGHS QARLVREMMK
SIVADQSHGT KNVLCNGLHE GGQSICISDL VSSSSWSILL HRIGDLLMCY LLRSLVFHSM
WFCEILYLQV LLRENINPKL QKQNVIQCCW LPKSIKNLIR NSKRCQYKKL FLKHCSVKCK
VAPDVTKNDG KAHYPPGGKA AYYDRSFSRL EAYSTHQQVA SFVWAVLKRI VPKPLLGNSF
GKRSLRTNIW KFIKLQRESK RYDVFYYPKS VWRDLTSNAI ASLNKKNFRI LRGEPRKAVR
HLNCSSRVRF LPKAKDMRPL VDLRAKSKDA NLNKCHLIMK KLRDEKPEMF GSSVFDYNNV
HQNLSQFISS KRSQLMKKLK AFDCVSHDMV LKMIDDAFKC DEYTVRKCSK GTICRILKEQ
FHHLLYEQIK CNILKIGQKY YLQQVGIAQG SKLSPNLCSL YYGHLENSVL SKFLHDSKLN
AGEAFSEPEY LLMRFIDDFI FISFSLEHAQ KFLNRMRRGF VFYNCYMNDS KYGFNFCAGN
SEPSSNRLYR GDDGVSFMPW SGLLINCETL EIQADYTRYM HSLIVRRMQD VELHYNVRPV
LKLRRKETIW LGLTAYIRVL QQKQSRYKDM LTLLTAELGR YCHLGHECDT LRYAVDDSHS
SMFWKFKF
//
