ID A0A0E0JDE5_ORYPU Unreviewed; 997 AA.
AC A0A0E0JDE5;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 53.
DE RecName: Full=leucine--tRNA ligase {ECO:0000256|ARBA:ARBA00013164};
DE EC=6.1.1.4 {ECO:0000256|ARBA:ARBA00013164};
DE AltName: Full=Leucyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00030520};
OS Oryza punctata (Red rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza.
OX NCBI_TaxID=4537 {ECO:0000313|EnsemblPlants:OPUNC01G01120.1};
RN [1] {ECO:0000313|EnsemblPlants:OPUNC01G01120.1}
RP NUCLEOTIDE SEQUENCE.
RA Wing R.;
RT "Oryza genome evolution.";
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblPlants:OPUNC01G01120.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-
CC tRNA(Leu); Xref=Rhea:RHEA:11688, Rhea:RHEA-COMP:9613, Rhea:RHEA-
CC COMP:9622, ChEBI:CHEBI:30616, ChEBI:CHEBI:33019, ChEBI:CHEBI:57427,
CC ChEBI:CHEBI:78442, ChEBI:CHEBI:78494, ChEBI:CHEBI:456215; EC=6.1.1.4;
CC Evidence={ECO:0000256|ARBA:ARBA00001372};
CC -!- SIMILARITY: Belongs to the class-I aminoacyl-tRNA synthetase family.
CC {ECO:0000256|ARBA:ARBA00005594, ECO:0000256|RuleBase:RU363035}.
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DR AlphaFoldDB; A0A0E0JDE5; -.
DR STRING; 4537.A0A0E0JDE5; -.
DR EnsemblPlants; OPUNC01G01120.1; OPUNC01G01120.1; OPUNC01G01120.
DR Gramene; OPUNC01G01120.1; OPUNC01G01120.1; OPUNC01G01120.
DR eggNOG; KOG0435; Eukaryota.
DR HOGENOM; CLU_004427_0_0_1; -.
DR OMA; TFMVLAP; -.
DR Proteomes; UP000026962; Chromosome 1.
DR GO; GO:0009507; C:chloroplast; IEA:EnsemblPlants.
DR GO; GO:0005739; C:mitochondrion; IEA:EnsemblPlants.
DR GO; GO:0002161; F:aminoacyl-tRNA editing activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004823; F:leucine-tRNA ligase activity; IEA:UniProtKB-EC.
DR GO; GO:0009793; P:embryo development ending in seed dormancy; IEA:EnsemblPlants.
DR GO; GO:0006429; P:leucyl-tRNA aminoacylation; IEA:InterPro.
DR CDD; cd07958; Anticodon_Ia_Leu_BEm; 1.
DR CDD; cd00812; LeuRS_core; 1.
DR Gene3D; 3.40.50.620; HUPs; 2.
DR Gene3D; 3.90.740.10; Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain; 1.
DR HAMAP; MF_00049_B; Leu_tRNA_synth_B; 1.
DR InterPro; IPR001412; aa-tRNA-synth_I_CS.
DR InterPro; IPR002300; aa-tRNA-synth_Ia.
DR InterPro; IPR002302; Leu-tRNA-ligase.
DR InterPro; IPR025709; Leu_tRNA-synth_edit.
DR InterPro; IPR013155; M/V/L/I-tRNA-synth_anticd-bd.
DR InterPro; IPR015413; Methionyl/Leucyl_tRNA_Synth.
DR InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR InterPro; IPR009080; tRNAsynth_Ia_anticodon-bd.
DR InterPro; IPR009008; Val/Leu/Ile-tRNA-synth_edit.
DR NCBIfam; TIGR00396; leuS_bact; 1.
DR PANTHER; PTHR43740:SF2; LEUCINE--TRNA LIGASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43740; LEUCYL-TRNA SYNTHETASE; 1.
DR Pfam; PF08264; Anticodon_1; 1.
DR Pfam; PF00133; tRNA-synt_1; 1.
DR Pfam; PF13603; tRNA-synt_1_2; 1.
DR Pfam; PF09334; tRNA-synt_1g; 1.
DR PRINTS; PR00985; TRNASYNTHLEU.
DR SUPFAM; SSF47323; Anticodon-binding domain of a subclass of class I aminoacyl-tRNA synthetases; 1.
DR SUPFAM; SSF52374; Nucleotidylyl transferase; 1.
DR SUPFAM; SSF50677; ValRS/IleRS/LeuRS editing domain; 1.
DR PROSITE; PS00178; AA_TRNA_LIGASE_I; 1.
PE 3: Inferred from homology;
KW Aminoacyl-tRNA synthetase {ECO:0000256|ARBA:ARBA00023146,
KW ECO:0000256|RuleBase:RU363035};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU363035};
KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000256|RuleBase:RU363035};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU363035};
KW Protein biosynthesis {ECO:0000256|ARBA:ARBA00022917,
KW ECO:0000256|RuleBase:RU363035};
KW Reference proteome {ECO:0000313|Proteomes:UP000026962}.
FT DOMAIN 99..230
FT /note="Methionyl/Leucyl tRNA synthetase"
FT /evidence="ECO:0000259|Pfam:PF09334"
FT DOMAIN 279..472
FT /note="Leucyl-tRNA synthetase editing"
FT /evidence="ECO:0000259|Pfam:PF13603"
FT DOMAIN 702..733
FT /note="Aminoacyl-tRNA synthetase class Ia"
FT /evidence="ECO:0000259|Pfam:PF00133"
FT DOMAIN 789..897
FT /note="Methionyl/Valyl/Leucyl/Isoleucyl-tRNA synthetase
FT anticodon-binding"
FT /evidence="ECO:0000259|Pfam:PF08264"
SQ SEQUENCE 997 AA; 112884 MW; D7216745C26176A0 CRC64;
MALAMMQTPL QLRLQPRPPA LASARHRRLR GFPPNPPRGG GWCRCCANAD AGKARRAYPY
DEIEPRWQRH WEEHRTFRTP DIGHGLDTSK PKCYILDMFP YPSGAGLHVG HPLGYTATDI
LSRFKRMQGF NVLHPMGWDA FGLPAEQYAI ETGTHPKITT ERNIDRFRSQ LKSLGFSYDW
DREISTTEPT YYKWTQWIFL QLLKRGLAYQ AEVPVNWCPA LGTVLANEEV IDGVSERGGH
PVIRKPMRQW MLRITSYADR LLEDLDELDW PESIKEMQRN WIGRSEGAEL EFSAVDKEGH
DLGANLLVYT TRPDTIFGAT YLVLAPEHSL LSSLISEEQR VHVEEYIELT ARKSELERTD
LQKEKTGVFS GSYAKNPATG EIVPIWVADY VLGSYGTGAI MAVPAHDSRD HEFALKYKLP
IIKVVSPLNG NCDSGEAYAD DGIMINSSSS SSGLNIDGML SKDAALKVTE WVEANGFGKK
KVNYKLRDWL FARQRYWGEP FPVIYRDDTN EMVPLQENQL PLTLPELDDF TPTGTGEPPL
TKATDWVKTI EPLSGKPARR ETSTMPQWAG SCWYYLRFMD PQNASMLVDK AKESYWGPVD
IYVGGAEHSV LHLLYARFWH KVLYDIGIVS TKEPFKCLIN QGLILGEVEY TAYRDNEGRW
VSADSNSSLV DCYQEKVPAD KVTKVGDHYV LKDDANIRLN ARAYKMSKSR GNVINPDDVV
SEYGADSLRL YEMFMGPLRD SKTWSTGGIE GVHRFLGRTW RLVVGTPLPD GSYGVGTTVT
DEESTLDQLR VLHKCIARVT EEIQETRFNT AISAMMEFVN AAYKWDTQPK SVIESFVLLL
SPFAPHMAEE LWFRLGHSRS LAHEQFPEAK SEYLKESKLV LPVQINGKTR GTILVDKECS
EDDAFQIAAL DEKLSKYLTG KGIRKRIYVP GRILNCRVAS HVGKEDFRLL MISRKATRAF
TNAGAIARTA AAVGYEVVVG ETDHQFITRT WARSRRR
//
