ID A0A0E0LWI9_ORYPU Unreviewed; 344 AA.
AC A0A0E0LWI9;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=phosphoribosylglycinamide formyltransferase 1 {ECO:0000256|ARBA:ARBA00012254};
DE EC=2.1.2.2 {ECO:0000256|ARBA:ARBA00012254};
DE AltName: Full=5'-phosphoribosylglycinamide transformylase {ECO:0000256|ARBA:ARBA00041682};
DE AltName: Full=GAR transformylase {ECO:0000256|ARBA:ARBA00041324};
OS Oryza punctata (Red rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza.
OX NCBI_TaxID=4537 {ECO:0000313|EnsemblPlants:OPUNC08G17550.4};
RN [1] {ECO:0000313|EnsemblPlants:OPUNC08G17550.4}
RP NUCLEOTIDE SEQUENCE.
RA Wing R.;
RT "Oryza genome evolution.";
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblPlants:OPUNC08G17550.4}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (APR-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(6R)-10-formyltetrahydrofolate + N(1)-(5-phospho-beta-D-
CC ribosyl)glycinamide = (6S)-5,6,7,8-tetrahydrofolate + H(+) + N(2)-
CC formyl-N(1)-(5-phospho-beta-D-ribosyl)glycinamide;
CC Xref=Rhea:RHEA:15053, ChEBI:CHEBI:15378, ChEBI:CHEBI:57453,
CC ChEBI:CHEBI:143788, ChEBI:CHEBI:147286, ChEBI:CHEBI:195366;
CC EC=2.1.2.2; Evidence={ECO:0000256|ARBA:ARBA00036742};
CC -!- PATHWAY: Purine metabolism; IMP biosynthesis via de novo pathway; N(2)-
CC formyl-N(1)-(5-phospho-D-ribosyl)glycinamide from N(1)-(5-phospho-D-
CC ribosyl)glycinamide (10-formyl THF route): step 1/1.
CC {ECO:0000256|ARBA:ARBA00005054}.
CC -!- SIMILARITY: Belongs to the GART family.
CC {ECO:0000256|ARBA:ARBA00038440}.
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DR AlphaFoldDB; A0A0E0LWI9; -.
DR STRING; 4537.A0A0E0LWI9; -.
DR EnsemblPlants; OPUNC08G17550.2; OPUNC08G17550.2; OPUNC08G17550.
DR EnsemblPlants; OPUNC08G17550.4; OPUNC08G17550.4; OPUNC08G17550.
DR Gramene; OPUNC08G17550.2; OPUNC08G17550.2; OPUNC08G17550.
DR Gramene; OPUNC08G17550.4; OPUNC08G17550.4; OPUNC08G17550.
DR eggNOG; KOG3076; Eukaryota.
DR OMA; SSCKRIW; -.
DR UniPathway; UPA00074; UER00126.
DR Proteomes; UP000026962; Chromosome 8.
DR GO; GO:0004644; F:phosphoribosylglycinamide formyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0006189; P:'de novo' IMP biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd08645; FMT_core_GART; 1.
DR Gene3D; 3.40.50.170; Formyl transferase, N-terminal domain; 1.
DR HAMAP; MF_01930; PurN; 1.
DR InterPro; IPR002376; Formyl_transf_N.
DR InterPro; IPR036477; Formyl_transf_N_sf.
DR InterPro; IPR004607; GART.
DR InterPro; IPR001555; GART_AS.
DR NCBIfam; TIGR00639; PurN; 1.
DR PANTHER; PTHR43369; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; 1.
DR PANTHER; PTHR43369:SF2; PHOSPHORIBOSYLGLYCINAMIDE FORMYLTRANSFERASE; 1.
DR Pfam; PF00551; Formyl_trans_N; 1.
DR SUPFAM; SSF53328; Formyltransferase; 1.
DR PROSITE; PS00373; GART; 1.
PE 3: Inferred from homology;
KW Purine biosynthesis {ECO:0000256|ARBA:ARBA00022755};
KW Reference proteome {ECO:0000313|Proteomes:UP000026962};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 131..316
FT /note="Formyl transferase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00551"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 67..90
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 344 AA; 36924 MW; 1B829483A68FD283 CRC64;
MRSDSTLSHF SRSSPAAGGA RVRRLRRARD PVVLSPLAVP PLSSRVAAEA WPGNLAMEAA
VASTGSGLRC SPNPMPKQQH ERRSARVGFV SQPRPRAVRC KRFPHPDARA YAAVGVGVKG
GEAGGVWVER KRLAVFVSGG GSNFRAIHDA ALGGEVNGDV VALVTDKPGC GGAEHARGNG
IPVVVFPKSK SAPEGVSADE LLNALRELRV DFILLAGYLK LIPVELVQAY PRSILNIHPS
LLPAFGGKGY YGLKVHKAVI ASGARYSGPT VHFVDEHYDT GRTLAQRVVP VLANDTPEQL
ATRVLHEEHQ VYVEAVAALC EDRIVWREDG VPLIRNQTNP DEYT
//
