ID A0A0E0NDR0_ORYRU Unreviewed; 528 AA.
AC A0A0E0NDR0;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=Vacuolar cation/proton exchanger {ECO:0000256|RuleBase:RU365028};
OS Oryza rufipogon (Brownbeard rice) (Asian wild rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza.
OX NCBI_TaxID=4529 {ECO:0000313|EnsemblPlants:ORUFI02G14210.3, ECO:0000313|Proteomes:UP000008022};
RN [1] {ECO:0000313|Proteomes:UP000008022}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. W1943 {ECO:0000313|Proteomes:UP000008022};
RA Zhao Q.;
RL Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblPlants:ORUFI02G14210.3}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- FUNCTION: Vacuolar cation/proton exchanger (CAX). Translocates Ca(2+)
CC and other metal ions into vacuoles using the proton gradient formed by
CC H(+)-ATPase and H(+)-pyrophosphatase. {ECO:0000256|ARBA:ARBA00025327,
CC ECO:0000256|RuleBase:RU365028}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Vacuole membrane
CC {ECO:0000256|RuleBase:RU365028}.
CC -!- SIMILARITY: Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19)
CC family. Cation/proton exchanger (CAX) subfamily.
CC {ECO:0000256|ARBA:ARBA00008248}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU365028}.
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DR AlphaFoldDB; A0A0E0NDR0; -.
DR EnsemblPlants; ORUFI02G14210.1; ORUFI02G14210.1; ORUFI02G14210.
DR EnsemblPlants; ORUFI02G14210.3; ORUFI02G14210.3; ORUFI02G14210.
DR EnsemblPlants; ORUFI02G14210.4; ORUFI02G14210.4; ORUFI02G14210.
DR Gramene; ORUFI02G14210.1; ORUFI02G14210.1; ORUFI02G14210.
DR Gramene; ORUFI02G14210.3; ORUFI02G14210.3; ORUFI02G14210.
DR Gramene; ORUFI02G14210.4; ORUFI02G14210.4; ORUFI02G14210.
DR eggNOG; KOG1397; Eukaryota.
DR OMA; SAMVWLI; -.
DR Proteomes; UP000008022; Unassembled WGS sequence.
DR GO; GO:0005774; C:vacuolar membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015369; F:calcium:proton antiporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1420.30; NCX, central ion-binding region; 2.
DR InterPro; IPR004713; CaH_exchang.
DR InterPro; IPR004798; CAX-like.
DR InterPro; IPR004837; NaCa_Exmemb.
DR InterPro; IPR044880; NCX_ion-bd_dom_sf.
DR NCBIfam; TIGR00378; cax; 1.
DR PANTHER; PTHR31503; VACUOLAR CALCIUM ION TRANSPORTER; 1.
DR PANTHER; PTHR31503:SF96; VACUOLAR CATION_PROTON EXCHANGER 1C; 1.
DR Pfam; PF01699; Na_Ca_ex; 2.
PE 3: Inferred from homology;
KW Antiport {ECO:0000256|RuleBase:RU365028};
KW Calcium {ECO:0000256|RuleBase:RU365028};
KW Calcium transport {ECO:0000256|RuleBase:RU365028};
KW Ion transport {ECO:0000256|RuleBase:RU365028};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU365028};
KW Reference proteome {ECO:0000313|Proteomes:UP000008022};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU365028};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU365028}; Transport {ECO:0000256|RuleBase:RU365028};
KW Vacuole {ECO:0000256|RuleBase:RU365028}.
FT TRANSMEM 167..192
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365028"
FT TRANSMEM 204..222
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365028"
FT TRANSMEM 243..260
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365028"
FT TRANSMEM 299..324
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365028"
FT TRANSMEM 336..363
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365028"
FT TRANSMEM 369..392
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365028"
FT TRANSMEM 404..423
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365028"
FT TRANSMEM 435..453
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU365028"
FT DOMAIN 102..260
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT DOMAIN 305..448
FT /note="Sodium/calcium exchanger membrane region"
FT /evidence="ECO:0000259|Pfam:PF01699"
FT REGION 28..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 528 AA; 56619 MW; 6B72976023056B08 CRC64;
MAPPESSHHH LLESGLLEVS KAPSAAVAAE EEEKKEAAAW TPSSSSSMTG RKIKSEASPL
LRRLLGGPAA QLQEVLLGTK LYPLFSAVPL AVAAESLRLG RVWVFAFSLI GLAPLAERVS
FLSEHIANTV GPTAGGIMNA TCGNVPELII ALFALHKNKM EILKWSLLGS ILSNLLLVLG
SSLLFGGIVN IGKERPLDKR QADVSIGLLL LGVLCHIATL VSKYTSSTGD SINSSSVMQL
SRSCAIVMLI AYFGSLVFQL KTHRQIFELE EGYNVLIKNE TWDSSDSSSS EDDATDKSVI
GFASAMVWLI GMAVVTAMLS SYVVTTIEEA SESMGIPVRF ISIILLPIVG NAAEHAGAII
FAFKNKIDIS LGITLGSATQ ISMLVVPVIL IVSWVNAIPM DLDFNLLETG SLAMAVITTA
FTLQDDKWHY LKGLNLVFSY IVIAVCFFVM KALPSIDGDA LAMAMVVRKL GIMAWINEEA
LSKPSDQVKV QTYHEGLSEL IRSVFAACNP NRPITHTPSG QTPLPLLS
//
