ID A0A0E0Q2T1_ORYRU Unreviewed; 2739 AA.
AC A0A0E0Q2T1;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=non-specific serine/threonine protein kinase {ECO:0000256|ARBA:ARBA00012513};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
OS Oryza rufipogon (Brownbeard rice) (Asian wild rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza.
OX NCBI_TaxID=4529 {ECO:0000313|EnsemblPlants:ORUFI06G29800.2, ECO:0000313|Proteomes:UP000008022};
RN [1] {ECO:0000313|Proteomes:UP000008022}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. W1943 {ECO:0000313|Proteomes:UP000008022};
RA Zhao Q.;
RL Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblPlants:ORUFI06G29800.2}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-seryl-[protein] = ADP + H(+) + O-phospho-L-seryl-
CC [protein]; Xref=Rhea:RHEA:17989, Rhea:RHEA-COMP:9863, Rhea:RHEA-
CC COMP:11604, ChEBI:CHEBI:15378, ChEBI:CHEBI:29999, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:83421, ChEBI:CHEBI:456216; EC=2.7.11.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001433};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-threonyl-[protein] = ADP + H(+) + O-phospho-L-
CC threonyl-[protein]; Xref=Rhea:RHEA:46608, Rhea:RHEA-COMP:11060,
CC Rhea:RHEA-COMP:11605, ChEBI:CHEBI:15378, ChEBI:CHEBI:30013,
CC ChEBI:CHEBI:30616, ChEBI:CHEBI:61977, ChEBI:CHEBI:456216;
CC EC=2.7.11.1; Evidence={ECO:0000256|ARBA:ARBA00000775};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
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DR STRING; 4529.A0A0E0Q2T1; -.
DR EnsemblPlants; ORUFI06G29800.2; ORUFI06G29800.2; ORUFI06G29800.
DR Gramene; ORUFI06G29800.2; ORUFI06G29800.2; ORUFI06G29800.
DR eggNOG; KOG0890; Eukaryota.
DR OMA; MVACELN; -.
DR Proteomes; UP000008022; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00892; PIKKc_ATR; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR012993; UME.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF72; SERINE-PROTEIN KINASE ATM; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF08064; UME; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM00802; UME; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000008022};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1609..2219
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2330..2642
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2640..2684
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 2739 AA; 305917 MW; B078C1EBF62890B8 CRC64;
MANFSSHIQE LRELIAASST TTSTSAPASV HFEVKLREVL PNLLRDYVVP SSPTADGREA
TAVLKLLSYT AGKFPGVFFH GRAADVIRVI GRVLPFFAEP NFRSRHEIIF DTVWSLLSLL
RTGDREAYRQ FFLDVMVAVQ DVLYVVASMH GDRPSGVLTE RYLVKCLCGS FSDILDSPGI
FSDLPDSCQP KNGPGVLVDL TGETRWRPFA TMLIKLVNKC LADGTLYVEG LVNMPFVSAA
CSIICYGDES LHKVCFDFAR IVATVITVEI LPVENIIRSI MCILSQDVNG LSDIRDADYD
FSMGACLHAL HSSCPGYIVA ITASDIVNVF QRAVHTSRSS ELQVAMCNAY KRIVELCSPR
VWKPEILLKL LCLPKPCAKL IECIRLVVDK SGQSFLSSDD RDDGSSLLAK SEGLDLPKVG
QKRIALDEEN SFPKRLKMTE PRFSSGSFMV DELSAGVGQE LEKDHGCDFR VQLYSLINCL
SPDNHMAYPL EPAISIQVLS LLCLSLSVYP KTNLFSRISK QVLSWIPWIC KQTTKICMFS
FDVSLYFEAV QTVMLLQSFL PGHTKLFEDE PLLIGNGCTD FEYPRYADLI NLLKLVSDDG
YLTSQTCSEK LKCLAVQIIA KIGSRQNAEC DLQVLELAIQ SETGELQNEA LMSLPIIVLY
SGPRMLGAMF RKLETIGTLG CKKLWKSIAI SLGFLSCLNG TTDCTDKVGN HCKLFLAKHC
EQPILTLNLL RGFWCPQCDV RTVHIEDQVP IVDIALSEDK NIDFKINMFK AHSLFFKFLY
AETSEECIVS IVEVLPRILK HSSRDVLLDM KFQWVQCVDF LLLHEMKAVR DAFSSVVSCF
LETNAMDILF SDGTGMSGGT SRVKFMDKIK SAFTEAEDPQ ILLTLLESTA AIVKASDIHG
EVFFCSFVLL IGQLGNHDYI VRVTALRLLQ RCCTYCFKGG LELFLSKYFH VRDNLYDYLS
SRLLTHPVVI SEFAESVLGV KTEELIRRMV PSIIPKLIVS HQNNDQAVVT LNELASHLNR
TDSKEIFSAA LPTLLDEIIC FPGESDQIET DRRMAKISPT IQNIARILTG NDNLPEFLKN
DFVRLLNSID KKMLHSSDVN LQKQALQRIR KLVEMMGPYL STHAPKIMVL LIFAIDKETL
QMDGLDVLHF FIKRLAEVSC TSIKYVMSQV VAAFIPSLER CRERPLVHLG KIVEILEELV
VKNIILLKQH IRELPLLPSL PSLSGVNKVI QEARGLMTLQ DHLKDAVNGL NHESLNVRYM
VACELNKLFN DRRGDITSLI IGEDIADLDI ISSLIMSLLK GCAEESRTVV GQRLKLVCAD
CLGALGAVDP AKFKVMSCER FKIECSDDDL IFELIHKHLA RAFRAASDTT VQDSAALAIQ
ELLKLSGCQS LPNESSSCKM SKRGQKLWGR FSSYVKEIIA PCLTSRFHLP SVNDATLAGP
IYRPTMSFRR WIYYWIRKLT SHATGSRSGI FGACRGIVRH DMPTAIYLLP YLVLNVVCYG
TPEARQSITE EILSVLNAAA SESSGAIVHG ITGGQSEVCI QAVFTLLDNL GQWVDDLKQE
IALSQSNYAM AGRQGGKLRD ESNSMYDQDQ LLVQCSNVAE LLAAIPKVTL AKASFRCQAH
ARALMYFESH VREKSGSSNP AADCSGAFSD DDISFLMEIY GGLDEPDGLL GLANLRKSST
LQDQLIINEK AGNWAEVLTL CEQSLQMEPD SVHRHCDVLN CLLNMCHLQA MIAHVDGLVY
RIPQSKKTWC MQGVQAAWRL GRWDLMDEYL AEADKGLVCR SSENNASFDM GLAKIFNAMM
KKDQFMVAEK IAQSKQALLV PLAAAGMDSY MRAYPYIVKL HMLRELEDFN SLLGDESFLE
KPFAADDPKF LKLTKDWENR LRCTQPSLWA REPLLAFRRM VYNLSHMNAQ AGNCWLQYAR
LCRLAGHYET AHRAILEADA SGAPNAHMEK AKYLWNIRKS DSAIAELQQT LLNMPADVLG
PTVLSSLSSL SLALPNAPLS VTQASKENPD VSKTLLLYTR WIHYTGQKQS NDIKSLYSRV
ADLRPKWEKG FFCIAKFYDD LLVDARRRQE DKKIASGVGP VPPSSTGSLT TATEEKPWWD
MLPVVLIQYA RGLHRGHKNL FQALPRLLTL WFEFGSIYIQ DGSSFNKPMK EVHIRLLGIM
RGCLKDLPPY QWLTVLSQLI SRICHQNIEV VKLVKCIVTS ILREYPQQAL WMMAAVSKST
VAARRDAAAE ILQSAKKGSR RGSDSNALFM QFPSLIDHLI KLCFHPGQPK ARAINISTEF
SSLKRMMPLG IILPIQQALT VTLPSYDTNM TDQSTFRPFS VSEHPTIAGI ADDAEILNSL
QKPKKVVFIG SDGISRPFLC KPKDDLRKDS RMMEFNAMIN RLLSKVPESR RRKLYIRTFA
VVPLTEDCGM VEWVPNTRGL RQILQDIYIT CGKFDRMKTN PQIKKIYDQL QGKMPEEMLK
AKILPMFPPV FHKWFLTTFS EPAAWIRARA AYAHTTAVWS MVGHIVGLGD RHGENILLDS
TTGDCIHVDF SCLFDKGLLL EKPEVVPFRF TQNMVDGLGI TGYEGVFVKV CEITLSVLRT
HKEALMTVLE TFIHDPLVEW TKSHKSSGVE VRNPHAQRAI SNITERLQGV VVGVNAAPSL
PLSVEGQARR LIAEAVSHSN LGKMYEAVKV GRTLTVVVDW CRSWKPSMAA HAGEKKSPMA
LYSHASLLSE KSSSKNACSS SSISFLSSSL CFASAAAIA
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