ID A0A0E0QMA1_ORYRU Unreviewed; 792 AA.
AC A0A0E0QMA1;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Myotubularin phosphatase domain-containing protein {ECO:0000259|PROSITE:PS51339};
OS Oryza rufipogon (Brownbeard rice) (Asian wild rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza.
OX NCBI_TaxID=4529 {ECO:0000313|EnsemblPlants:ORUFI08G25820.1, ECO:0000313|Proteomes:UP000008022};
RN [1] {ECO:0000313|Proteomes:UP000008022}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. W1943 {ECO:0000313|Proteomes:UP000008022};
RA Zhao Q.;
RL Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblPlants:ORUFI08G25820.1}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-
CC phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
CC inositol) + phosphate; Xref=Rhea:RHEA:12316, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:57880, ChEBI:CHEBI:58088; EC=3.1.3.64;
CC Evidence={ECO:0000256|ARBA:ARBA00001291};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR AlphaFoldDB; A0A0E0QMA1; -.
DR STRING; 4529.A0A0E0QMA1; -.
DR EnsemblPlants; ORUFI08G25820.1; ORUFI08G25820.1; ORUFI08G25820.
DR Gramene; ORUFI08G25820.1; ORUFI08G25820.1; ORUFI08G25820.
DR eggNOG; KOG4471; Eukaryota.
DR HOGENOM; CLU_017601_0_0_1; -.
DR OMA; HICESLC; -.
DR Proteomes; UP000008022; Unassembled WGS sequence.
DR GO; GO:0004438; F:phosphatidylinositol-3-phosphate phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR CDD; cd14507; PTP-MTM-like; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF8; PHOSPHATIDYLINOSITOL-3-PHOSPHATE PHOSPHATASE; 1.
DR Pfam; PF06602; Myotub-related; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008022}.
FT DOMAIN 163..599
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 631..658
FT /evidence="ECO:0000256|SAM:Coils"
FT ACT_SITE 407
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-1"
FT BINDING 292..295
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
FT BINDING 317..318
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
FT BINDING 407..413
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
SQ SEQUENCE 792 AA; 88851 MW; 4730541C78244330 CRC64;
MDGSGSWDAI DWNQIKEPRP PRSSSRGMED FLLEDEEVYA QGHGVVLLNT DEAGILSVTN
FRLLFVSQAT KGVIELGTIP LTAIEKINDD VKLQPLPRQH DKKQPRELLQ VIGKDMRVIV
FDFLPKTKQK NEVFDALRRY SKPTHLWDLY AFSCDPSTVY QKSDPKMRLL KEYHRLFRKW
FPHSGSEFEK DLRNEWWRVS KVNSTYSLCS TYPSALIVPR SIRFIASFFF PIRQTLACYF
VGLELFWQGH LSHCNTDEKL VSALCTQIID ATGSLRKLYI VDARPRANAL ANGAKGGGSE
SASNYPRSEV LFLGIQNIHT MRDSLFRLRD YVDTHGSVSS NGTSSAVSLV GDRRNRGSTW
GGGNLNSMTQ FSSMLGEWLN HIQSIMVGAS WIAAQIVQES ASVLVHCSDG WDRTTQLVAL
ACLLLDPYYR TFNGFQALVE KDWLAFGHPF AERMGVPTIT DNNSGSQFEL LRQPSLGTLS
NSPNRGALGS SVSTSNTTSG QSQTSNNSSP ILLQKFLVDF MDCVLSCRFG NFLCNSERER
EQSGAVSSCH CMWTYLADLR ASGGSFHKHR NPFYDPLKHN GPLVPPAAAL APTLWPQFYL
RWTCPIESQG GDLESQWHAM NKKYTEAMKA KDTAESRVKD IKTKMESMQL ELQREKRASS
SALAMAQRAQ RESVAIRKAV RSLGCTVNFG TNESQVEKTE GLTYSFRRDT DFESQHEKSS
DFSVSITAIE DSLVSETPSN HICESLCPFR TREGCRWPDA ACAQLGSQFV GLKANFDAFD
RLSVQDSYFG SE
//
