ID A0A0E0QMA2_ORYRU Unreviewed; 748 AA.
AC A0A0E0QMA2;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=Myotubularin phosphatase domain-containing protein {ECO:0000259|PROSITE:PS51339};
OS Oryza rufipogon (Brownbeard rice) (Asian wild rice).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Oryzoideae; Oryzeae; Oryzinae; Oryza.
OX NCBI_TaxID=4529 {ECO:0000313|EnsemblPlants:ORUFI08G25820.2, ECO:0000313|Proteomes:UP000008022};
RN [1] {ECO:0000313|Proteomes:UP000008022}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=cv. W1943 {ECO:0000313|Proteomes:UP000008022};
RA Zhao Q.;
RL Submitted (JUN-2013) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EnsemblPlants:ORUFI08G25820.2}
RP IDENTIFICATION.
RG EnsemblPlants;
RL Submitted (JUN-2015) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-
CC phosphate) + H2O = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-
CC inositol) + phosphate; Xref=Rhea:RHEA:12316, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:57880, ChEBI:CHEBI:58088; EC=3.1.3.64;
CC Evidence={ECO:0000256|ARBA:ARBA00001291};
CC -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family. Non-
CC receptor class myotubularin subfamily. {ECO:0000256|ARBA:ARBA00007471}.
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DR AlphaFoldDB; A0A0E0QMA2; -.
DR EnsemblPlants; ORUFI08G25820.2; ORUFI08G25820.2; ORUFI08G25820.
DR Gramene; ORUFI08G25820.2; ORUFI08G25820.2; ORUFI08G25820.
DR Proteomes; UP000008022; Unassembled WGS sequence.
DR GO; GO:0004438; F:phosphatidylinositol-3-phosphate phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR010569; Myotubularin-like_Pase_dom.
DR InterPro; IPR030564; Myotubularin_fam.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR PANTHER; PTHR10807; MYOTUBULARIN-RELATED; 1.
DR PANTHER; PTHR10807:SF8; PHOSPHATIDYLINOSITOL-3-PHOSPHATE PHOSPHATASE; 1.
DR Pfam; PF06602; Myotub-related; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51339; PPASE_MYOTUBULARIN; 1.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000008022}.
FT DOMAIN 163..555
FT /note="Myotubularin phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS51339"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..319
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..463
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 587..614
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 297..319
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 363
FT /note="Phosphocysteine intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-1"
FT BINDING 292..295
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
FT BINDING 363..369
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR630564-2"
SQ SEQUENCE 748 AA; 84047 MW; C721446AE4457974 CRC64;
MDGSGSWDAI DWNQIKEPRP PRSSSRGMED FLLEDEEVYA QGHGVVLLNT DEAGILSVTN
FRLLFVSQAT KGVIELGTIP LTAIEKINDD VKLQPLPRQH DKKQPRELLQ VIGKDMRVIV
FDFLPKTKQK NEVFDALRRY SKPTHLWDLY AFSCDPSTVY QKSDPKMRLL KEYHRLFRKW
FPHSGSEFEK DLRNEWWRVS KVNSTYSLCS TYPSALIVPR SIRFIASFFF PIRQTLACYF
VGLELFWQGH LSHCNTDEKL VSALCTQIID ATGSLRKLYI VDARPRANAL ANGAKGGGSE
SASNYPRSER NRGSTWGGGN LNSMTQFSSM LGEWLNHIQS IMVGASWIAA QIVQESASVL
VHCSDGWDRT TQLVALACLL LDPYYRTFNG FQALVEKDWL AFGHPFAERM GVPTITDNNS
GSQFELLRQP SLGTLSNSPN RGALGSSVST SNTTSGQSQT SNNSSPILLQ KFLVDFMDCV
LSCRFGNFLC NSEREREQSG AVSSCHCMWT YLADLRASGG SFHKHRNPFY DPLKHNGPLV
PPAAALAPTL WPQFYLRWTC PIESQGGDLE SQWHAMNKKY TEAMKAKDTA ESRVKDIKTK
MESMQLELQR EKRASSSALA MAQRAQRESV AIRKAVRSLG CTVNFGTNES QVEKTEGLTY
SFRRDTDFES QHEKSSDFSV SITAIEDSLV SETPSNHICE SLCPFRTREG CRWPDAACAQ
LGSQFVGLKA NFDAFDRLSV QDSYFGSE
//
