ID A0A0E0SLZ3_GIBZE Unreviewed; 2087 AA.
AC A0A0E0SLZ3;
DT 13-APR-2016, integrated into UniProtKB/TrEMBL.
DT 13-APR-2016, sequence version 1.
DT 28-JUN-2023, entry version 31.
DE RecName: Full=separase {ECO:0000256|ARBA:ARBA00012489};
DE EC=3.4.22.49 {ECO:0000256|ARBA:ARBA00012489};
GN Name=FG05504.1 {ECO:0000313|EnsemblFungi:CEF87456};
GN ORFNames=FGRAMPH1_01T18081 {ECO:0000313|EMBL:CEF87456.1};
OS Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084
OS / PH-1) (Wheat head blight fungus) (Fusarium graminearum).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium.
OX NCBI_TaxID=229533 {ECO:0000313|EnsemblFungi:CEF87456};
RN [1] {ECO:0000313|EnsemblFungi:CEF87456, ECO:0000313|Proteomes:UP000070720}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1
RC {ECO:0000313|Proteomes:UP000070720}, and PH-1 / ATCC MYA-4620 / FGSC
RC 9075 / NRRL 31084 {ECO:0000313|EnsemblFungi:CEF87456};
RX PubMed=17823352; DOI=10.1126/science.1143708;
RA Cuomo C.A., Gueldener U., Xu J.-R., Trail F., Turgeon B.G., Di Pietro A.,
RA Walton J.D., Ma L.-J., Baker S.E., Rep M., Adam G., Antoniw J., Baldwin T.,
RA Calvo S.E., Chang Y.-L., DeCaprio D., Gale L.R., Gnerre S., Goswami R.S.,
RA Hammond-Kosack K., Harris L.J., Hilburn K., Kennell J.C., Kroken S.,
RA Magnuson J.K., Mannhaupt G., Mauceli E.W., Mewes H.-W., Mitterbauer R.,
RA Muehlbauer G., Muensterkoetter M., Nelson D., O'Donnell K., Ouellet T.,
RA Qi W., Quesneville H., Roncero M.I.G., Seong K.-Y., Tetko I.V., Urban M.,
RA Waalwijk C., Ward T.J., Yao J., Birren B.W., Kistler H.C.;
RT "The Fusarium graminearum genome reveals a link between localized
RT polymorphism and pathogen specialization.";
RL Science 317:1400-1402(2007).
RN [2] {ECO:0000313|EnsemblFungi:CEF87456, ECO:0000313|Proteomes:UP000070720}
RP GENOME REANNOTATION.
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1
RC {ECO:0000313|Proteomes:UP000070720}, and PH-1 / ATCC MYA-4620 / FGSC
RC 9075 / NRRL 31084 {ECO:0000313|EnsemblFungi:CEF87456};
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.B., Woloshuk C., Xie X., Xu J.R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.H., Li L., Manners J.M., Miranda-Saavedra D., Mukherjee M.,
RA Park G., Park J., Park S.Y., Proctor R.H., Regev A., Ruiz-Roldan M.C.,
RA Sain D., Sakthikumar S., Sykes S., Schwartz D.C., Turgeon B.G.,
RA Wapinski I., Yoder O., Young S., Zeng Q., Zhou S., Galagan J., Cuomo C.A.,
RA Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=PH-1;
RA King R., Urban M., Hassani-Pak K., Hammond-Kosack K.;
RT "A revised Fusarium graminearum genomic reference sequence using whole
RT shotgun re-sequencing.";
RL Submitted (FEB-2014) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000313|EMBL:CEF87456.1, ECO:0000313|Proteomes:UP000070720}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1
RC {ECO:0000313|Proteomes:UP000070720}, and PH-1
RC {ECO:0000313|EMBL:CEF87456.1};
RX PubMed=26198851; DOI=10.1186/s12864-015-1756-1;
RA King R., Urban M., Hammond-Kosack M.C., Hassani-Pak K.,
RA Hammond-Kosack K.E.;
RT "The completed genome sequence of the pathogenic ascomycete fungus Fusarium
RT graminearum.";
RL BMC Genomics 16:544-544(2015).
RN [5] {ECO:0000313|EnsemblFungi:CEF87456}
RP IDENTIFICATION.
RC STRAIN=PH-1 / ATCC MYA-4620 / FGSC 9075 / NRRL 31084
RC {ECO:0000313|EnsemblFungi:CEF87456};
RG EnsemblFungi;
RL Submitted (JAN-2017) to UniProtKB.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=All bonds known to be hydrolyzed by this endopeptidase have
CC arginine in P1 and an acidic residue in P4. P6 is often occupied by
CC an acidic residue or by a hydroxy-amino-acid residue, the
CC phosphorylation of which enhances cleavage.; EC=3.4.22.49;
CC Evidence={ECO:0000256|ARBA:ARBA00000451};
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DR EMBL; HG970334; CEF87456.1; -; Genomic_DNA.
DR STRING; 229533.A0A0E0SLZ3; -.
DR EnsemblFungi; CEF87456; CEF87456; FGRRES_16492.
DR VEuPathDB; FungiDB:FGRAMPH1_01G18081; -.
DR eggNOG; KOG1849; Eukaryota.
DR InParanoid; A0A0E0SLZ3; -.
DR Proteomes; UP000070720; Chromosome 3.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0098813; P:nuclear chromosome segregation; IEA:UniProt.
DR GO; GO:0000280; P:nuclear division; IEA:UniProt.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR InterPro; IPR005314; Peptidase_C50.
DR InterPro; IPR030397; SEPARIN_core_dom.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR PANTHER; PTHR12792; EXTRA SPINDLE POLES 1-RELATED; 1.
DR PANTHER; PTHR12792:SF0; SEPARIN; 1.
DR Pfam; PF03568; Peptidase_C50; 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS51700; SEPARIN; 1.
DR PROSITE; PS50005; TPR; 1.
PE 4: Predicted;
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Reference proteome {ECO:0000313|Proteomes:UP000070720};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT REPEAT 1188..1221
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DOMAIN 1872..1968
FT /note="Peptidase C50"
FT /evidence="ECO:0000259|PROSITE:PS51700"
FT REGION 41..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 86..150
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1284..1329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2021..2045
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 41..55
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..107
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..150
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2087 AA; 229390 MW; F3B310A4AA53B918 CRC64;
MASLQAKADA VKTALTSTST CTTATVVTLK ELLLLDVDNS TTTSKTATNS KAKKAAPAKQ
QLPPKDRAAL ATHVINICIK SLNEAAKPSV PTTPSKRQAS QSDLKNPSAP RRLRRSLSAP
LSPLQPRTLN RVATSPNVTS KATSQPPPQS TGCLAVVECA RTAFSFLRST IGSVQPTQTD
FQLENGMSAF IGKLLTLGFQ DQALKELRIL KRRLDSGVSK ATKPTSSEAQ TAAQVIAELL
DYGDKVPDNL LAVVTGCQFQ VLRWISHSKK PRHIEAALPF LEESHLSSPV TLYERLGAKD
KKETQKAARQ LASLSQTILS FAPSVSSKED QVATEIRLSP SPTSAFKLQV LCFKAQLKWW
KMAGHRGSID DDILSPFSRC VRAYTRRHPS ANGPTYDLIA TSFQQLMDLM GSQKSQAKTS
SESPLTLLYQ LLGVAAQTDR QYEEACQWFQ TLKSVLNPDE ESAIRIFSVS ARLLAASLKQ
SKYDSATKEL VQEVTESLEG SLSGNITDLN ELLDSLSLAR RSAVGLLVSN SKDSKSKNST
VSTIMQHLKT FITKFPRFGR RWLGAPPGRD ASPKTLLQFD QRRETLMQTI SQIIDGALVV
INGDIQKDST SWKQMDEVLW DCNKLVDSVL DPAISISRTE QLSGYFVKIS SLYFARYNQL
RKDLGKSKQI NKEILQCLSR SIEIIQDRPM AQQEKAQIST KLELFADLCK AGNRSEEAIR
TLRSICTNMI EDGALVKVTA ALDSQPPSVA WSADGKAETL SRTLRSIAKL DQSWNDWAFF
LQENERAAVL EHLMQIVGDT TSKGEPLKLH DPSVQALLKI YTPERFPVRR LRVLLHLLFQ
VIGEENEMEQ IIKLVEESTQ QLDNEAYGED SSLTRYIPHL RTLKKSVSAL AVTDAPLPVP
VLRDAITSWK SMTESCKSRC ELYEQIDNPD GLVLHLQSAS QFASLRGEHR LQLEILELST
PLSKILAEPT YNNVILNHTL LASQHLNIGH FAEAKETLDA TKKLLDQAEG VSRGLIAEFH
LTQAEYYSGI GDIEEANSAL AAAKAIYSGS ASSWALSRSQ ANMSIALSSF LESVLALKRG
QVQEALISVK SSVRVLSHDW SKIEASVSQS ASTSVMDAST TSSDSVKAGS KLGQVIGPRF
WALAFPLLRG LLHVSSVYAH LGMYQETVYY AESAQKIAET TGSPLYRAQV LAWIGSVYHR
AGKLTKALDF GNEAFEELPE DISASRVRVA CQLGGLFRDT GDEDKALQLL QLAEDTAQRL
GDHGKVLSIQ NEVKKTAPVA AKARAAATTR ATRTAARTTR AKAAPAAAPA PAPKTRKRQA
ATKSQPSALE VSKLPKDAYQ ASLMASVILS RALGFISQKD WTSALSTLEL AKELPKLLGT
LSQEQVVTAI SLIGHSTEQM IHDPVFSVVQ DSTISFPAVA ASDKTRRSVS QTPPRKGRAV
AAATERKASK EANVPAFAEA LRQAQELLLE AHASTLSTAN STMVHRISAL LQNTVILLSA
TSTTQSKVLA GSGFATFSVD LARNVTWKRE QSTLQNKECT ETDGSGSVQT SRRDSVGLTT
EMAKFQEDYI DLVPHNWSVF SVSLSDNHHD LCITKFQAGH SPFILRLPLE RANSRDADSE
IFNFEHGKEE MMDIIRLANE TSHSASRDFS VKGAKSAWWA ERDALDGRLK DLLATVETTW
LGGFKGIFSQ HERRPDLLAR FQKSFDQILD SNLPSRKQGR GKKPTKTSKV SLDPRVLDLF
IGLGDPTDPD SDYDEALNDL LYFVVDILQF HGERNAYDEI DFDAMVVETY DALRGYYNAV
KTGSERAEDA HTILVLDKAL HAFPWESMPC MEGLAVSRVP SLACLRQLIT ESRPFANDDD
SDDAPEGHYV SADRGTYILN PSTDLVNTQS TFQPIMEGFR NWNGIVNRAP QEAEFEKALS
DSEILLYFGH GSGAQYIRAR AIRRLEKCKP ATFLMGCSSA SLTEAGEFEN YGPVWNYMMA
GCPAVVGTLW DVTDRDIDRF AGRSFEEWGL FPKGTFKEDK RAKGKSRASG EDETTASESE
EDGQVTRNVS LAEAVARSRE ACRFKYLNAA AVVLYGIPVY IKHKGDE
//
