ID A0A0E1RWR3_COCIM Unreviewed; 315 AA.
AC A0A0E1RWR3;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 28-JUN-2023, entry version 23.
DE SubName: Full=dTDP-4-dehydrorhamnose reductase {ECO:0000313|EMBL:EAS30963.2};
GN ORFNames=CIMG_06442 {ECO:0000313|EMBL:EAS30963.2};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS30963.2, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
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DR EMBL; GG704912; EAS30963.2; -; Genomic_DNA.
DR RefSeq; XP_001242546.2; XM_001242545.2.
DR AlphaFoldDB; A0A0E1RWR3; -.
DR STRING; 246410.A0A0E1RWR3; -.
DR GeneID; 4562074; -.
DR KEGG; cim:CIMG_06442; -.
DR VEuPathDB; FungiDB:CIMG_06442; -.
DR InParanoid; A0A0E1RWR3; -.
DR OMA; RMPLMFG; -.
DR OrthoDB; 3080056at2759; -.
DR UniPathway; UPA00315; UER00080.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0006556; P:S-adenosylmethionine biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd05254; dTDP_HR_like_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR005913; dTDP_dehydrorham_reduct.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR029903; RmlD-like-bd.
DR PANTHER; PTHR10491; DTDP-4-DEHYDRORHAMNOSE REDUCTASE; 1.
DR PANTHER; PTHR10491:SF4; METHIONINE ADENOSYLTRANSFERASE 2 SUBUNIT BETA; 1.
DR Pfam; PF04321; RmlD_sub_bind; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000001261}.
FT DOMAIN 4..295
FT /note="RmlD-like substrate binding"
FT /evidence="ECO:0000259|Pfam:PF04321"
SQ SEQUENCE 315 AA; 34689 MW; 51B0963296C0881D CRC64;
MTQKALVTGA SGLLGRQVLN AFKKDVNWEA VGQGFTRAAP PDIVKADLTN PSEIESLLDE
VKPQVVVHCA ANRFPDQCDA HPDLARKVNV EATKALAKAT LQRSILLIYI STDYVFPGRP
GEAPYETSSQ TEPPNIYGQT KLDGEIAVIE TTQGSGKGVV LRVPVLYGSA DTNSESAVNV
LIDAVWKAQD ADAKVKMDDW GQRYPTNTED VGRVCHDIAV KYLGEQERAA SFPTILQFSS
EDKVTKYEMC ERFAEILGLP LSGMERIKQG GTPGNGVQRP FDTHLSTKAL KELGIPVDTQ
DFVSWWRREL RAYRH
//
