ID A0A0E1RXI5_COCIM Unreviewed; 638 AA.
AC A0A0E1RXI5;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Carnitine acetyl transferase {ECO:0000313|EMBL:EAS34172.2};
GN ORFNames=CIMG_05196 {ECO:0000313|EMBL:EAS34172.2};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS34172.2, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SIMILARITY: Belongs to the carnitine/choline acetyltransferase family.
CC {ECO:0000256|ARBA:ARBA00005232, ECO:0000256|RuleBase:RU003801}.
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DR EMBL; GG704914; EAS34172.2; -; Genomic_DNA.
DR RefSeq; XP_001245755.2; XM_001245754.2.
DR AlphaFoldDB; A0A0E1RXI5; -.
DR STRING; 246410.A0A0E1RXI5; -.
DR GeneID; 4564619; -.
DR KEGG; cim:CIMG_05196; -.
DR VEuPathDB; FungiDB:CIMG_05196; -.
DR InParanoid; A0A0E1RXI5; -.
DR OMA; MAMSSYE; -.
DR OrthoDB; 1429709at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 1.
DR Gene3D; 3.30.559.70; Choline/Carnitine o-acyltransferase, domain 2; 1.
DR InterPro; IPR000542; Carn_acyl_trans.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR039551; Cho/carn_acyl_trans.
DR InterPro; IPR042231; Cho/carn_acyl_trans_2.
DR PANTHER; PTHR22589:SF115; CARNITINE O-ACETYLTRANSFERASE, MITOCHONDRIAL; 1.
DR PANTHER; PTHR22589; CARNITINE O-ACYLTRANSFERASE; 1.
DR Pfam; PF00755; Carn_acyltransf; 1.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 2.
DR PROSITE; PS00440; ACYLTRANSF_C_2; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315,
KW ECO:0000256|RuleBase:RU003801};
KW Reference proteome {ECO:0000313|Proteomes:UP000001261};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU003801}.
FT DOMAIN 61..614
FT /note="Choline/carnitine acyltransferase"
FT /evidence="ECO:0000259|Pfam:PF00755"
FT ACT_SITE 352
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR600542-1"
SQ SEQUENCE 638 AA; 71855 MW; 98C13A37E5C5A4EB CRC64;
MFPAAARGRL VALGRASLPR PARTPVITMA ARRANSSVPA GYTEDLSKGR MLRFEDSLPQ
LPVPTLEETG KKYLKSLHPL LSAEEFKRSQ KAVEAFVKPG GEGETLQKRL LAKAADPKVQ
NWLYDWWNHA AYLGYRDPVV PYVSYFYSYR DDRNRRDPAK RAAAITTSVL EFKKQVDDGS
LEPEYLRKEP MAMSSYEYMF NCCRIPAEGA DYPQKYPAQG NEHIVVMRKN QIFKVQTHLN
GEQLNTSELQ QQFEKILKNA ERVPAVGALT SENRDFWTAA RKKLLAADPA NADALKTIEG
ASFVVCLDDT APVTLEERAH VYWHGDGANR WFDKPLTFIV NDNGTAGFLG EHSMMDGTPT
HRLNDYVNNL IFNNRLDYSN PSVRSNLPEP QPVNFNLDSA VLEDITTAQK DFASVIGKHE
LRVQAFQAYG KGLIKKFKCS PDAYVQMLIQ LAYFKMYGKN RPTYESASTR KFKQGRTETT
RTVSDESVAF CKAHCDPAVP REETAKLFRA ALAAHTKYIA DASVGKGVDR HLFGLKQLIQ
KGEKVPALYE DPAYGYSGSW YLSTSQLSSE YFNGYGWSQV IDDGFGIAYM INENSLQFNI
VCKKLGADRM SFYLNEAACE VRDLLMPDLL AQQEKAKL
//
