ID A0A0E1RXW8_COCIM Unreviewed; 1913 AA.
AC A0A0E1RXW8;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 24-JAN-2024, entry version 48.
DE SubName: Full=Amino acid adenylation domain-containing protein {ECO:0000313|EMBL:EAS31819.2};
GN ORFNames=CIMG_07298 {ECO:0000313|EMBL:EAS31819.2};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS31819.2, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
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DR EMBL; GG704912; EAS31819.2; -; Genomic_DNA.
DR RefSeq; XP_001243402.2; XM_001243401.2.
DR STRING; 246410.A0A0E1RXW8; -.
DR GeneID; 4562383; -.
DR KEGG; cim:CIMG_07298; -.
DR VEuPathDB; FungiDB:CIMG_07298; -.
DR InParanoid; A0A0E1RXW8; -.
DR OMA; YTIWEVT; -.
DR OrthoDB; 3305653at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0003824; F:catalytic activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR CDD; cd05918; A_NRPS_SidN3_like; 1.
DR CDD; cd19545; FUM14_C_NRPS-like; 1.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 2.
DR Gene3D; 3.30.559.10; Chloramphenicol acetyltransferase-like domain; 2.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR Gene3D; 3.30.559.30; Nonribosomal peptide synthetase, condensation domain; 2.
DR InterPro; IPR010071; AA_adenyl_domain.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR InterPro; IPR023213; CAT-like_dom_sf.
DR InterPro; IPR001242; Condensatn.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR NCBIfam; TIGR01733; AA-adenyl-dom; 1.
DR PANTHER; PTHR45527:SF1; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR45527; NONRIBOSOMAL PEPTIDE SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF00668; Condensation; 2.
DR Pfam; PF00550; PP-binding; 2.
DR SMART; SM00823; PKS_PP; 2.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR SUPFAM; SSF47336; ACP-like; 2.
DR SUPFAM; SSF52777; CoA-dependent acyltransferases; 4.
DR PROSITE; PS00455; AMP_BINDING; 1.
DR PROSITE; PS50075; CARRIER; 2.
PE 4: Predicted;
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001261}.
FT DOMAIN 754..831
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 1432..1508
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1913 AA; 212423 MW; E2D3CDFA088588E3 CRC64;
MQESDIESCL FPRLSILGST QRPRGVYSCP LFECQDIGSE ANILPYLTTA WSILLAKYAD
TPTAQFGVFP EGVTSQPQQI IEEWSASFEP TRCVREAVLL QKVRGWLFHD CEYRGRFNSC
VIHGCSTSWI DQWAELSDHP IALILLVETT ETPRVSLYCQ SSLLDEGLLG LLRSALQHIL
RSLSENPKGS LQSLEFTSES HRRQIHDWNE SVPKEAVDKC IHHLIQRQCF DQPAAEAICA
WDGSLTYAEL DDLSSSVMHV LHGYSIGPET IVPLLFEKSK WTAVSMFGVL KAGAAFVLLD
PAHPDERLQV ICQDVGANVI LTSTLYKQTS SGLADTVIVV PYIADISGPE DTATVIRREK
KTSSTSRNAA YVSYTSGSTG KPKGIVIEHA SMCTNALSSS EAQNLTGSSR VLQFASYAFD
VSIHETLVPL MLGGCVCVPS DSQRVNNLQE AIIELCVNWM ELTPSVARLL TPEEIPAVKT
MVVGGESMPP TEIARWAARM RLVIAYGPAE CTVVSTVQAH VAVDGDPLNI GRGYGGTTWV
VEAENHNKLV PIGAAGELLI GGPIVGREYL NRPQQTTDAF VASPPWMTSK GESSRVYKTG
DLVRQLADGT LVYLGRKDTQ VKLRGQRIEL GEIEHFARDI FPGAAVAVEM GKLYHGRPAL
VLFVEWEPFK DGTIQGSDDG SLPFCKPNHL FEINIPKVKA RLDGAFPRYM VPELLIPLRA
MPLSQTTKVD RKSLRSMISK LTKNDLQAYR LTSNHSGRLG MEFIRLIAHV LALSPDEILE
DDDFFHLGGD SISAIKLAKE TQKIPGLMLT VTDIFQTPVI SQLCQKAQKE RIASPTASIP
VGVLRFSLVD SANAESLKQL AADQCGVPPY QLEDIYPCSP LQERLMARTA RQPGAFQARF
TFRMPTNIDW NRLRCAWGVV ADSFAILRTR IVNAGQLQST HSILQAVVRG QDIEWLETEQ
TNRHGDSRWE RLMSFGTPLI YLVACRDSSN PTLTLVMHHA LFDWWSYNQI LDAVKNAYLG
QYVDLKYFSP FIKYIADLSK REAREFWKQE FSGLQEAPFL AHRSASTASQ AFKWTQRDIH
LRLSNQRGAT TSSMIRLAWA MVVCQHTSSL DAVFGVTVMG RSIDGAADTT GPTIATHPVR
IRLQENLEIN EALKRMQDHR TALIPFEQTG IQEIQQASPE AAMACEFQSL LVVQPQSEKG
TQMELSSPLL WELENDTSWK QQSYANFSTQ ILNVICEPEA DKLTVNAFFD DTVLSEKQVQ
SMLECMERFL GTIVHNPTER IESILGEKCE PERAPDVFQE RKSLAKLELT ARTYLGDRFQ
VVAEWITPKG MRTSKLVLFV GVPDVDIATV DTLILTRLEA HIHAQLSQLM IHLRNGSLGS
LVPACCIPIR LQSVPSESIV LLGRAFWQEA ASKLTWSALR AWEKAGRVHA HKSLTSTEAK
LQGALASVLR LEPDDIGIHD DFVTLGCDSL IAMQFAAMCI RDSMTVSVSD IFHAKSVARL
ALKVGSTIPA VALVPHSFSS VQSMYGDLRL FERDMKGFDE ISNVTQVIDA FPCTSTHLGL
LPQDSYLQAH TIWELTGLSD MIDPFRLAGA WGRLVDHHSI LRTVLLQSKS SPSKIFQVVL
SDAPVDVDIV RGVEDENIWP VVRKPFLSSC GRDELPLKFT VYQTTTGRVF CKLEGRHAFL
DATSVSIILQ ELGPAYNGTV PPAPEALYQL WASYLHEWGG DSSHLKFWRR YLAGIRPCIF
NPRQQVNGIN GVNGSSRSGR ELRVHTTALA QAGALRKYCD KVGFNMTNVI QVAWALLLRK
LTGLDDVCFG TLVSGRDAPV PNVSSIIGPL FNLLVCRFSM VENKPLRRIL EDNELAIRER
LRHQHCSLKE VTMACSDGHS PLFNTCLSVE QPLSSKAGIC FREVETHEET EVD
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