ID   A0A0E1RZ47_COCIM        Unreviewed;      1108 AA.
AC   A0A0E1RZ47;
DT   27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT   27-MAY-2015, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   SubName: Full=PH domain-containing protein {ECO:0000313|EMBL:EAS34738.1};
GN   ORFNames=CIMG_00092 {ECO:0000313|EMBL:EAS34738.1};
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS34738.1, ECO:0000313|Proteomes:UP000001261};
RN   [1] {ECO:0000313|Proteomes:UP000001261}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2] {ECO:0000313|Proteomes:UP000001261}
RP   GENOME REANNOTATION.
RC   STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
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DR   EMBL; GG704911; EAS34738.1; -; Genomic_DNA.
DR   RefSeq; XP_001246321.1; XM_001246320.2.
DR   AlphaFoldDB; A0A0E1RZ47; -.
DR   STRING; 246410.A0A0E1RZ47; -.
DR   GeneID; 4566230; -.
DR   KEGG; cim:CIMG_00092; -.
DR   VEuPathDB; FungiDB:CIMG_00092; -.
DR   InParanoid; A0A0E1RZ47; -.
DR   OMA; DRWVMSI; -.
DR   OrthoDB; 1360556at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:1902657; P:protein localization to prospore membrane; IEA:InterPro.
DR   InterPro; IPR040345; Mug56/Spo71.
DR   InterPro; IPR039486; Mug56/Spo71_PH.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR029217; Spo7_2_N.
DR   PANTHER; PTHR28076:SF1; PROSPORE MEMBRANE ADAPTER PROTEIN SPO71; 1.
DR   PANTHER; PTHR28076; SPORULATION-SPECIFIC PROTEIN 71; 1.
DR   Pfam; PF15404; PH_4; 1.
DR   Pfam; PF15407; Spo7_2_N; 1.
DR   SMART; SM00233; PH; 2.
DR   SMART; SM01316; Spo7_2_N; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000001261}.
FT   DOMAIN          654..859
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   REGION          113..220
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          256..330
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        168..220
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        256..308
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        310..326
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1108 AA;  126133 MW;  E3F72A9065CE6EA5 CRC64;
     MSGERPCEQP VPTCWRRFPR GEYHSLDSES YTAQRLQHAS PEHLHVTSRR LFIGPLPKGW
     LSSHRKSWYK SWLGLKDYSS RTATFSADIN LAHQRQLTGL FGPSTAAMYR QSFPQPEDVD
     EEAEEEELVA AGATVEPAAI TTADTAHETP YRYGPEPAQE PPPEPTSELT AEHSQLSTVT
     PTSTSRPQPD SVSSKSDPGS NPPSSSQIHE SYYSAPESHK NASRILSATS PISEESLESG
     NYGVNENTKS AGVISRRMSP HGQSLTPSIP SATGETASGT NFTSQTYLLS GRKSINDRSP
     SSLSSPRLRH EEPSLVEQED SRNKSRPRRL MKRLAPGIVR FNIEDSINDR QRRLQKRLTR
     TASELESTAK KQRQASRCGA IVRAERMLVR IESTTQTVPD DYNENESIKI DTKVVSKWRE
     FLVVCREGCE ADTPFLLQFY KTRVIPQVQT SDMKKKWSYE IPIVRSHTKV NLFSTLDKTL
     VVWHRFKPET QIFIMRPRSS AHSVEWYTFI RGGLGWKQPS ILFVHVPDLD ITLRLENPFA
     HLGMNQNEDD DVCSAVLRTM KEERAIASGI IKTCLNTLSE CCEWNKILAM WGKSAKMGLA
     WRRYDRLEWV QGPNEQRMYG TMAMRTTHEL ELRPKQHYPT STTLQKGGPK VEEPAPTEGF
     LILLTSQRGR QRLIGKNFFK RLYFYTQDQF LCFCRPGKAT PPAPPSLPTI TGRNIPTSAE
     IIRETPIVYD VDPFPVNNGE VTWLTVGRKE YAKSHDAEAF AENRRITKNA ANTEGYINMC
     RVAEIRPVSS QTSQEEQHAN AGDVEYHGER GRAVHGARHE TKEERSFEIV LDDGLVVLFR
     TYNMQTRQEW IRRLTELSDY WKARTKKDIA TLKYIRSRNL KRLEIDEAQE SMLGQFAQKW
     EVSRAEASSE LFHACGMSGC RPIKMSGNLY RKPRRHGAFT HCSVLLIEGQ LLIFQSSLRR
     WTGEQLPHTY HSRQAVLDLR DCYIYSGIIT SSDLLYQHQT FDSNLPSQLE RPRMYTQDGW
     TASDEDIATC FVIWHATRKA LFRGELTKTG KPKRSGWKQV SALGVPGKAI VFKARSRAER
     DLWVLAIATE IDRLQQQEDL RIVKSPCI
//