ID A0A0E1RZU0_COCIM Unreviewed; 668 AA.
AC A0A0E1RZU0;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Rho GTPase activator {ECO:0000313|EMBL:EAS35065.2};
GN ORFNames=CIMG_00419 {ECO:0000313|EMBL:EAS35065.2};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS35065.2, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
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DR EMBL; GG704911; EAS35065.2; -; Genomic_DNA.
DR RefSeq; XP_001246648.2; XM_001246647.2.
DR AlphaFoldDB; A0A0E1RZU0; -.
DR STRING; 246410.A0A0E1RZU0; -.
DR GeneID; 4565877; -.
DR KEGG; cim:CIMG_00419; -.
DR VEuPathDB; FungiDB:CIMG_00419; -.
DR InParanoid; A0A0E1RZU0; -.
DR OMA; DSGWQAR; -.
DR OrthoDB; 5482027at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07652; F-BAR_Rgd1; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23176:SF138; RHO GTPASE ACTIVATOR; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|PROSITE-ProRule:PRU01077, ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000001261}.
FT DOMAIN 46..319
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 475..665
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..46
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 345..467
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 139..191
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 345..381
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 384..399
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 422..442
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 668 AA; 74384 MW; 6B61E3B7E35D2502 CRC64;
MAEPTVNEAS ELTSPHQSLE MPAPPSPPDN EAEAPQAVPA NQEEKEKLDR VILSDIGVVT
LLNRLKQSIS SAREFASFLR KRSSLEEDHA QGLKKLSRAL HDSSMRSENR QGSFAQSYDE
MNRIHDRMAD HGLQFAVSLQ QMSEDLNELA ANMERGRKHW KQNGLNAEKR VQDAEAAAEK
AKVKYDSLAE QYDRARTGDR QPGKFGLKGP KSAAQYEEDL LRKVQNADAD YANKVQAAQT
QKQELVATLR PQATRALQDL INECDSALTL QIQKFAAFSE RLLLGSGLSV SPLKNEVNGN
TAAPKSLRDA ARQVDNERDF KDYILSHSSK VSSNATTIRY ERHPTLITPQ SQNASAHPKR
QSLSINTAQT PPPQTAAQAF AQMTPHHPPP PPAQVQHAPQ PQHAPPSFQH PHQEIFLTQP
PVQHHPQPPY PTSAPPHQPY SPAHTRPSFS LDRAAPPTNA GHHPDLPPLN PVFGVSLEDL
FLRDGTAIPM IVYQCIQAVE LFGLNVEGIY RLSGNTLHIQ RMKALFDNDS SKVDFTNPEN
FHHDVNSVAG LLKQFFRELP DPLFTNERYQ DFINAARKDD DVQRRDTLHA LINSLPDPNY
ATLRALILHL NHVQERASEN RMNAGNIAIS FGLTLMGSNA GHNIADSGWQ ARVIETVLQN
TFQIFDDD
//
