ID A0A0E1S3C8_COCIM Unreviewed; 479 AA.
AC A0A0E1S3C8;
DT 27-MAY-2015, integrated into UniProtKB/TrEMBL.
DT 27-MAY-2015, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Fork-head domain-containing protein {ECO:0000259|PROSITE:PS50039};
GN ORFNames=CIMG_04570 {ECO:0000313|EMBL:EAS33546.2};
OS Coccidioides immitis (strain RS) (Valley fever fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX NCBI_TaxID=246410 {ECO:0000313|EMBL:EAS33546.2, ECO:0000313|Proteomes:UP000001261};
RN [1] {ECO:0000313|Proteomes:UP000001261}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=19717792; DOI=10.1101/gr.087551.108;
RA Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA Henn M.R., Birren B.W., Taylor J.W.;
RT "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT and their relatives.";
RL Genome Res. 19:1722-1731(2009).
RN [2] {ECO:0000313|Proteomes:UP000001261}
RP GENOME REANNOTATION.
RC STRAIN=RS {ECO:0000313|Proteomes:UP000001261};
RX PubMed=20516208; DOI=10.1101/gr.103911.109;
RA Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA Taylor J.W., Rounsley S.D.;
RT "Population genomic sequencing of Coccidioides fungi reveals recent
RT hybridization and transposon control.";
RL Genome Res. 20:938-946(2010).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PROSITE-ProRule:PRU00089}.
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DR EMBL; GG704914; EAS33546.2; -; Genomic_DNA.
DR RefSeq; XP_001245129.2; XM_001245128.2.
DR AlphaFoldDB; A0A0E1S3C8; -.
DR STRING; 246410.A0A0E1S3C8; -.
DR GeneID; 4565075; -.
DR KEGG; cim:CIMG_04570; -.
DR VEuPathDB; FungiDB:CIMG_04570; -.
DR InParanoid; A0A0E1S3C8; -.
DR OMA; CNELIPR; -.
DR OrthoDB; 5385885at2759; -.
DR Proteomes; UP000001261; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IEA:UniProt.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR001766; Fork_head_dom.
DR InterPro; IPR030456; TF_fork_head_CS_2.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR45881; CHECKPOINT SUPPRESSOR 1-LIKE, ISOFORM A-RELATED; 1.
DR PANTHER; PTHR45881:SF5; FORK-HEAD DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00250; Forkhead; 1.
DR SMART; SM00339; FH; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS00658; FORK_HEAD_2; 1.
DR PROSITE; PS50039; FORK_HEAD_3; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU00089};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW ProRule:PRU00089}; Reference proteome {ECO:0000313|Proteomes:UP000001261};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 248..343
FT /note="Fork-head"
FT /evidence="ECO:0000259|PROSITE:PS50039"
FT DNA_BIND 248..343
FT /note="Fork-head"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00089"
FT REGION 333..397
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 479 AA; 52641 MW; 26B43EFFB466C967 CRC64;
MEEVPMSHSV HSAQAHTTCT PLNITRLNEK LSLQQPSFSL EPVSSPAGPI DEFSLSHFAI
NMLSSRDLSE NYSSHSVQDS LSDPYTWEFD MNELSGDSGL FYHQAPDVLE NIPSSPSRFG
HAEYEHESWI DINRSFPTPE NIDHLATFQD FQTAHEHQEL NSPVSVPDKE IAPSYDLQSC
IGSCPSFEGS TSRPGSAVYS YFTTDNSMAS SPLGDLLPLL QPRSVPDIGI GLSEEDSDTD
GIPSDEPYAI LIWKALMSAP GHGMVLKEIY EWFEKHTNKA KDPDSKGWQN SIRHNLSMNA
AFEAVREISS PGGSPKKSGN VWVLTERAIK HGVQSTTRYR KPGIHKKTTK SEQPAPQRQR
SGAKGGRAAK KAAKFRRALQ EAQRAGENHS SSRHMQSDNA EGIAAYTTHG EQEQPISPAN
LEMNLTLGGY NFSDLSGCTD LPPESPIFYH NIRTGGGGLI PDCSTLDSET IGLDFNSFM
//
