ID A0A0E3KW71_9EURY Unreviewed; 1150 AA.
AC A0A0E3KW71;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 24-JAN-2024, entry version 47.
DE RecName: Full=DNA polymerase II large subunit {ECO:0000256|HAMAP-Rule:MF_00324};
DE Short=Pol II {ECO:0000256|HAMAP-Rule:MF_00324};
DE EC=2.7.7.7 {ECO:0000256|HAMAP-Rule:MF_00324};
DE AltName: Full=Exodeoxyribonuclease large subunit {ECO:0000256|HAMAP-Rule:MF_00324};
DE EC=3.1.11.1 {ECO:0000256|HAMAP-Rule:MF_00324};
GN Name=polC {ECO:0000256|HAMAP-Rule:MF_00324};
GN ORFNames=MSWH1_0082 {ECO:0000313|EMBL:AKB20353.1};
OS Methanosarcina sp. WH1.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=1434102 {ECO:0000313|EMBL:AKB20353.1, ECO:0000313|Proteomes:UP000033112};
RN [1] {ECO:0000313|EMBL:AKB20353.1, ECO:0000313|Proteomes:UP000033112}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WH1 {ECO:0000313|EMBL:AKB20353.1,
RC ECO:0000313|Proteomes:UP000033112};
RA Henriksen J.R., Luke J., Reinhart S., Benedict M.N., Youngblut N.D.,
RA Metcalf M.E., Whitaker R.J., Metcalf W.W.;
RT "Methanogenic archaea and the global carbon cycle.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Possesses two activities: a DNA synthesis (polymerase) and an
CC exonucleolytic activity that degrades single-stranded DNA in the 3'- to
CC 5'-direction. Has a template-primer preference which is characteristic
CC of a replicative DNA polymerase. {ECO:0000256|ARBA:ARBA00025068,
CC ECO:0000256|HAMAP-Rule:MF_00324}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Exonucleolytic cleavage in the 3'- to 5'-direction to yield
CC nucleoside 5'-phosphates.; EC=3.1.11.1; Evidence={ECO:0000256|HAMAP-
CC Rule:MF_00324};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632, ECO:0000256|HAMAP-
CC Rule:MF_00324};
CC -!- SUBUNIT: Heterodimer of a large subunit and a small subunit.
CC {ECO:0000256|ARBA:ARBA00011315, ECO:0000256|HAMAP-Rule:MF_00324}.
CC -!- SIMILARITY: Belongs to the archaeal DNA polymerase II family.
CC {ECO:0000256|ARBA:ARBA00011053, ECO:0000256|HAMAP-Rule:MF_00324}.
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DR EMBL; CP009504; AKB20353.1; -; Genomic_DNA.
DR RefSeq; WP_048125100.1; NZ_CP009504.1.
DR AlphaFoldDB; A0A0E3KW71; -.
DR GeneID; 24812537; -.
DR KEGG; mef:MSWH1_0082; -.
DR PATRIC; fig|1434102.4.peg.100; -.
DR HOGENOM; CLU_001154_0_0_2; -.
DR Proteomes; UP000033112; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008310; F:single-stranded DNA 3'-5' DNA exonuclease activity; IEA:UniProtKB-EC.
DR GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR GO; GO:0006261; P:DNA-templated DNA replication; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00324; DNApol_II_L_arch; 1.
DR InterPro; IPR004475; PolC_DP2.
DR InterPro; IPR016033; PolC_DP2_N.
DR NCBIfam; TIGR00354; polC; 1.
DR PANTHER; PTHR42210; DNA POLYMERASE II LARGE SUBUNIT; 1.
DR PANTHER; PTHR42210:SF1; DNA POLYMERASE II LARGE SUBUNIT; 1.
DR Pfam; PF03833; PolC_DP2; 1.
DR PIRSF; PIRSF016275; PolC_DP2; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705, ECO:0000256|HAMAP-
KW Rule:MF_00324};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00324};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932,
KW ECO:0000256|HAMAP-Rule:MF_00324};
KW Exonuclease {ECO:0000256|ARBA:ARBA00022839, ECO:0000256|HAMAP-
KW Rule:MF_00324};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|HAMAP-Rule:MF_00324};
KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268, ECO:0000256|HAMAP-
KW Rule:MF_00324};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722, ECO:0000256|HAMAP-Rule:MF_00324};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695, ECO:0000256|HAMAP-
KW Rule:MF_00324};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|HAMAP-
KW Rule:MF_00324}.
FT DOMAIN 12..895
FT /note="DNA polymerase II large subunit DP2 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03833"
SQ SEQUENCE 1150 AA; 128293 MW; A6367E03CDE92CCF CRC64;
MGETIASEEM HEYFNGLEAR LKEAIEVANR ARSRGGDPKP TVEIPLAKDL ADRVENLIGV
KGVAAKIREL EVNMSREEAA LEVGRQVAEG IVGSFPAKKD AVEAAIRVSM AVLTEGVVAA
PIEGIDKVDL GKNDDGSQYI RIFYSGPIRS AGGTAQALSV LVGDYVRRGI GIDRYKPRDE
EIERYVEEIL LYKRVASLQY MPSEDEIRLI VRNCPVCIDG DPTEEAEVEG HRNLERIGTN
RVRGGMCLVL AEGLALKAPK VKKHVNKLKM DGWDWLETLI GGAKSGESAE DEQKNKIKPK
DKYIRDLIAG RPVFSHPSRP GGFRLRYGRS RNTSFASAGI SPASMVLLDD FIANGTQLKV
ERPGKAAAMS AVDSIEGPTV RLFSGDLIRI DNIKEAYEVR PQVEVIVDIG EILINYGDFL
ENNHPLMPSP YVFEWWQYDY QAACPEQIPE DELKNPSAAL ALRLAEEFNV PLHPKFTYLW
HDINRNEFEA LRNFVAEKGS FLAGEVAGAG VLKLPMKASL EEGIKPVLEK LLVLHRVKDD
EILIEEALPF ILCLGLDPSL KEKASMPDLD DMVEAAGVLS GFKVYPRAPS RIGARMGRPE
KSDLRKMSPA AQVLFPLNNS GGITRNLVSA SDYTSCMNGK IGEIEVELGL RECPACRKET
YFWRCECGEF TNPKLFCSRC KIDVRGAEVC PKCGRKPTSV ANVKLDFRSI YKQAFENLGE
REKMGLIKGV KRLMNGQMTP EPLEKGILRS KHNVYVFKDG TIRYDMSDIP LTHIRADELG
ITAAKLLELG YREDICGNPL ERDDQVVCLK VQDLVISYDG AEYMLRTAKY VDDLLVKYYK
IEPYYNAETI QDLVGVLLIG LAPHTSAGVL GRLIGFTKAS VGYAHPFFHA SKRRNCDGDE
DCIMLLMDGI LNFSRSYLPD KRGGKMDAPL VLTTRIDPKE VDKEAHNIDV SARYPFEFYR
ATQEIKSPTE LESIMDLISS RLGTPEQYEH FMFTHDTSNI AAGPLNSSYK TLGSMIEKME
AQLTLANRIR AVDASDVAER VLKSHFLPDL IGNLRSFSRQ RMRCIKCGEK FRRPPLTGAC
PKCGGNVILT VHEGSVRKYL EISKEIGERY GVSSYTRQRI ELLDYDISSL FENHRVKQLG
LSDFMSGSAR
//