ID A0A0E3L5A3_9EURY Unreviewed; 672 AA.
AC A0A0E3L5A3;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=Glutathione-regulated potassium-efflux system protein KefC {ECO:0000313|EMBL:AKB22921.1};
GN ORFNames=MSWH1_2650 {ECO:0000313|EMBL:AKB22921.1};
OS Methanosarcina sp. WH1.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=1434102 {ECO:0000313|EMBL:AKB22921.1, ECO:0000313|Proteomes:UP000033112};
RN [1] {ECO:0000313|EMBL:AKB22921.1, ECO:0000313|Proteomes:UP000033112}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WH1 {ECO:0000313|EMBL:AKB22921.1,
RC ECO:0000313|Proteomes:UP000033112};
RA Henriksen J.R., Luke J., Reinhart S., Benedict M.N., Youngblut N.D.,
RA Metcalf M.E., Whitaker R.J., Metcalf W.W.;
RT "Methanogenic archaea and the global carbon cycle.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
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DR EMBL; CP009504; AKB22921.1; -; Genomic_DNA.
DR RefSeq; WP_048129588.1; NZ_CP009504.1.
DR AlphaFoldDB; A0A0E3L5A3; -.
DR GeneID; 24815304; -.
DR KEGG; mef:MSWH1_2650; -.
DR PATRIC; fig|1434102.4.peg.3463; -.
DR HOGENOM; CLU_005126_9_0_2; -.
DR Proteomes; UP000033112; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR42751:SF3; NA(+)_H(+) ANTIPORTER; 1.
DR PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02080; TrkA_C; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 1.
DR PROSITE; PS51202; RCK_C; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..24
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 31..49
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 61..80
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 92..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..135
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 147..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 183..206
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 218..251
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 271..289
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 296..319
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..378
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 419..540
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
FT DOMAIN 583..669
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 672 AA; 73434 MW; 243ECBAE59D84C59 CRC64;
MEFSVLAHVD VILGFAILIL TIFYKFEVPP VLGFLVTGML IGPHGLGILD SGQNMELNAE
LGIVFLLFTI GVDLSLRELW KMKKAVMAGG TLQLLFTTTL ALIVCTWIGF SPAKSIFIGF
LISLSSTAIV LKVLQDRNEV YTPHGKTSLA ILIYQDLAIV PLILITPVLA GSSVSFEGAL
PNIFFKGSLI ILVFILSARF LVPWIFYHVG KTGSKQLFFV SVVFICLSAA VFTSSIGLSL
ALGAFLAGIV ISGSQYSQQA MGNILPLKDM FMSFFFVSVG MLLDISYLFN HLPILILATI
TLIVIKIIAG VGVTSLLGFP LRTTLLTGLA LAQVGEFSFV LSRLGMEYTL LTEETYQAFL
AVSILTMGVT PFLISASYKP ADFIVKKASS TAFGMKLVQG IYSESLDDEE QKEPQMKDHL
IIAGFGFSGK TVSKAAKAAG IPYIILETNP EIVQKEKAKG EKIQYGDATF GAVQEHAGIK
SARVLVTGIS DAAITRKIVE KAKELNPSIC IIAKVHDLQE MKRLNALGAD EIIPEEYETS
VEIFTRLLEK YLVPREDIEK MVNDVRANGY RRLRKLVVDT DIDSGFSIKD GLPGIDIQVL
KVGKDSYFDG KTLADLGFRR KHGVTVLSVR RRSNMISTPA GDFILQANDA CILLGKPGDL
YNVRKFFESA RR
//
