ID A0A0E3L5N0_9EURY Unreviewed; 382 AA.
AC A0A0E3L5N0;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE SubName: Full=Methylcobamide:CoM methyltransferase MtaA {ECO:0000313|EMBL:AKB23556.1};
GN ORFNames=MSMTP_0087 {ECO:0000313|EMBL:AKB23556.1};
OS Methanosarcina sp. MTP4.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=1434100 {ECO:0000313|EMBL:AKB23556.1, ECO:0000313|Proteomes:UP000033049};
RN [1] {ECO:0000313|EMBL:AKB23556.1, ECO:0000313|Proteomes:UP000033049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MTP4 {ECO:0000313|EMBL:AKB23556.1,
RC ECO:0000313|Proteomes:UP000033049};
RA Henriksen J.R., Luke J., Reinhart S., Benedict M.N., Youngblut N.D.,
RA Metcalf M.E., Whitaker R.J., Metcalf W.W.;
RT "Methanogenic archaea and the global carbon cycle.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
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DR EMBL; CP009505; AKB23556.1; -; Genomic_DNA.
DR RefSeq; WP_048177071.1; NZ_CP009505.1.
DR AlphaFoldDB; A0A0E3L5N0; -.
DR STRING; 1434100.MSMTP_0087; -.
DR GeneID; 24855280; -.
DR KEGG; metm:MSMTP_0087; -.
DR PATRIC; fig|1434100.4.peg.113; -.
DR HOGENOM; CLU_040933_2_1_2; -.
DR OrthoDB; 124836at2157; -.
DR Proteomes; UP000033049; Chromosome.
DR GO; GO:0008168; F:methyltransferase activity; IEA:UniProtKB-KW.
DR GO; GO:0004853; F:uroporphyrinogen decarboxylase activity; IEA:InterPro.
DR GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-KW.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR GO; GO:0006730; P:one-carbon metabolic process; IEA:InterPro.
DR GO; GO:0006779; P:porphyrin-containing compound biosynthetic process; IEA:InterPro.
DR CDD; cd03307; Mta_CmuA_like; 1.
DR Gene3D; 3.20.20.210; -; 1.
DR InterPro; IPR006360; Mtase_MtaA_CmuA.
DR InterPro; IPR038071; UROD/MetE-like_sf.
DR InterPro; IPR000257; Uroporphyrinogen_deCOase.
DR NCBIfam; TIGR01463; mtaA_cmuA; 1.
DR NCBIfam; NF040654; MtaA_Meth; 1.
DR PANTHER; PTHR47099; METHYLCOBAMIDE:COM METHYLTRANSFERASE MTBA; 1.
DR PANTHER; PTHR47099:SF1; METHYLCOBAMIDE:COM METHYLTRANSFERASE MTBA; 1.
DR Pfam; PF01208; URO-D; 1.
DR SUPFAM; SSF51726; UROD/MetE-like; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methanogenesis {ECO:0000256|ARBA:ARBA00022994};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:AKB23556.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000033049};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AKB23556.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 7..337
FT /note="Uroporphyrinogen decarboxylase (URO-D)"
FT /evidence="ECO:0000259|Pfam:PF01208"
SQ SEQUENCE 382 AA; 41773 MW; 15ED772DDD6424E7 CRC64;
MTDYNLRDRF LNVLKGKAVD RAPVLSVTQT GTVSLMEKCG AFWPEAHSNP EKMAALSLAA
HEITRLEAVR YPYCVTVLSE AMGCKVSRGT KETQPYVTFP PLGNSGELPE IPYSLLEKGR
IPTVLEATAL LKNKTEGTLP LIVGIESPAA LCSRLLGAGN YLRQLLKSPD YIRECLEINT
DACIEYANAL FEEGVDAVCV PDGISGPDLL NLEIFDLLIK PAYRRFCKKV KGPKILHMCG
DASPFLGTLS ECGFEGISVE EKVRDLKSAK KNLGNGICLI GNVSSSSTLL CGSREDVKEE
ARKALEGGVD ILAPGCGIAP MTPLENMKAL VEARDEYYGS VFSCFEDCKS KCYESKSYGS
GCHESKYRES ESYESKCYEP EY
//
