ID   A0A0E3NUH7_9EURY        Unreviewed;       458 AA.
AC   A0A0E3NUH7;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   RecName: Full=mannose-1-phosphate guanylyltransferase {ECO:0000256|ARBA:ARBA00012387};
DE            EC=2.7.7.13 {ECO:0000256|ARBA:ARBA00012387};
GN   ORFNames=MSMTP_0721 {ECO:0000313|EMBL:AKB24190.1};
OS   Methanosarcina sp. MTP4.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=1434100 {ECO:0000313|EMBL:AKB24190.1, ECO:0000313|Proteomes:UP000033049};
RN   [1] {ECO:0000313|EMBL:AKB24190.1, ECO:0000313|Proteomes:UP000033049}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MTP4 {ECO:0000313|EMBL:AKB24190.1,
RC   ECO:0000313|Proteomes:UP000033049};
RA   Henriksen J.R., Luke J., Reinhart S., Benedict M.N., Youngblut N.D.,
RA   Metcalf M.E., Whitaker R.J., Metcalf W.W.;
RT   "Methanogenic archaea and the global carbon cycle.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=alpha-D-mannose 1-phosphate + GTP + H(+) = diphosphate + GDP-
CC         alpha-D-mannose; Xref=Rhea:RHEA:15229, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57527,
CC         ChEBI:CHEBI:58409; EC=2.7.7.13;
CC         Evidence={ECO:0000256|ARBA:ARBA00001083};
CC   -!- SIMILARITY: Belongs to the mannose-6-phosphate isomerase type 2 family.
CC       {ECO:0000256|ARBA:ARBA00006115, ECO:0000256|RuleBase:RU004190}.
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DR   EMBL; CP009505; AKB24190.1; -; Genomic_DNA.
DR   RefSeq; WP_048177910.1; NZ_CP009505.1.
DR   AlphaFoldDB; A0A0E3NUH7; -.
DR   STRING; 1434100.MSMTP_0721; -.
DR   GeneID; 24855956; -.
DR   KEGG; metm:MSMTP_0721; -.
DR   PATRIC; fig|1434100.4.peg.938; -.
DR   HOGENOM; CLU_035527_1_0_2; -.
DR   OrthoDB; 5825at2157; -.
DR   Proteomes; UP000033049; Chromosome.
DR   GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR   GO; GO:0016853; F:isomerase activity; IEA:UniProtKB-KW.
DR   GO; GO:0004475; F:mannose-1-phosphate guanylyltransferase (GTP) activity; IEA:UniProtKB-EC.
DR   GO; GO:0000271; P:polysaccharide biosynthetic process; IEA:InterPro.
DR   CDD; cd02213; cupin_PMI_typeII_C; 1.
DR   CDD; cd02509; GDP-M1P_Guanylyltransferase; 1.
DR   Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR   InterPro; IPR049577; GMPP_N.
DR   InterPro; IPR006375; Man1P_GuaTrfase/Man6P_Isoase.
DR   InterPro; IPR001538; Man6P_isomerase-2_C.
DR   InterPro; IPR005835; NTP_transferase_dom.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   InterPro; IPR014710; RmlC-like_jellyroll.
DR   InterPro; IPR011051; RmlC_Cupin_sf.
DR   NCBIfam; TIGR01479; GMP_PMI; 1.
DR   PANTHER; PTHR46390; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR   PANTHER; PTHR46390:SF1; MANNOSE-1-PHOSPHATE GUANYLYLTRANSFERASE; 1.
DR   Pfam; PF01050; MannoseP_isomer; 1.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
DR   SUPFAM; SSF51182; RmlC-like cupins; 1.
PE   3: Inferred from homology;
KW   GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW   Isomerase {ECO:0000313|EMBL:AKB24190.1};
KW   Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW   Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695,
KW   ECO:0000313|EMBL:AKB24190.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000033049};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:AKB24190.1}.
FT   DOMAIN          5..273
FT                   /note="Nucleotidyl transferase"
FT                   /evidence="ECO:0000259|Pfam:PF00483"
FT   DOMAIN          304..453
FT                   /note="Mannose-6-phosphate isomerase type II C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF01050"
SQ   SEQUENCE   458 AA;  51794 MW;  8052B791D4B1DC24 CRC64;
     MKSIKSIILA GGSGTRLWPL SREMYPKQFL KFGERSLFQD TVLRCLEISK IEELFVVTNE
     AQKFFVMGQI KEIGHEIPSE NILIEPEGRN TLPAILYGMK EIERIFGKST VGIFSSDHVL
     DKAAMQTISS AEELVSASLV TFGVVPTFPN TGYGYVKPAE PLGPGYRVSG FREKPGEETA
     KKYIEEGCLW NSGMFLFDTD LFFEEVRKHA PEVLSCFEQF EDIAGIYENV EKISVDYGIM
     EKSDRVAVVR LDHKWSDLGN FSAIYDEFEK DLDENVVHRC DPFLLNSTGN LVHSKSGKIV
     SLIDVSDFVV VDTPDALLVC PKESSQKVKE IVTELKDRDD ERAYIGQKVY RPWGSYSLLE
     NSAGHKIKNI AVLPEHKLSL QMHYHRSEHW VVVKGMACVE VNGEKFFLRP GESTFIRAGE
     KHRLSNPGKV PLEIIEVQLG ELVDEGDIVR FDDVYGRY
//