ID A0A0E3NV16_9EURY Unreviewed; 979 AA.
AC A0A0E3NV16;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE SubName: Full=Membrane alanine aminopeptidase N {ECO:0000313|EMBL:AKB24515.1};
DE EC=3.4.11.2 {ECO:0000313|EMBL:AKB24515.1};
GN ORFNames=MSMTP_1046 {ECO:0000313|EMBL:AKB24515.1};
OS Methanosarcina sp. MTP4.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=1434100 {ECO:0000313|EMBL:AKB24515.1, ECO:0000313|Proteomes:UP000033049};
RN [1] {ECO:0000313|EMBL:AKB24515.1, ECO:0000313|Proteomes:UP000033049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MTP4 {ECO:0000313|EMBL:AKB24515.1,
RC ECO:0000313|Proteomes:UP000033049};
RA Henriksen J.R., Luke J., Reinhart S., Benedict M.N., Youngblut N.D.,
RA Metcalf M.E., Whitaker R.J., Metcalf W.W.;
RT "Methanogenic archaea and the global carbon cycle.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP009505; AKB24515.1; -; Genomic_DNA.
DR RefSeq; WP_048178182.1; NZ_CP009505.1.
DR AlphaFoldDB; A0A0E3NV16; -.
DR STRING; 1434100.MSMTP_1046; -.
DR GeneID; 24856301; -.
DR KEGG; metm:MSMTP_1046; -.
DR PATRIC; fig|1434100.4.peg.1355; -.
DR HOGENOM; CLU_004958_0_0_2; -.
DR OrthoDB; 139771at2157; -.
DR Proteomes; UP000033049; Chromosome.
DR GO; GO:0004177; F:aminopeptidase activity; IEA:UniProtKB-KW.
DR GO; GO:0008237; F:metallopeptidase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR Gene3D; 2.60.40.1840; -; 1.
DR Gene3D; 1.10.390.10; Neutral Protease Domain 2; 1.
DR Gene3D; 1.25.50.10; Peptidase M1, alanyl aminopeptidase, C-terminal domain; 1.
DR Gene3D; 2.60.40.1730; tricorn interacting facor f3 domain; 1.
DR InterPro; IPR045357; Aminopeptidase_N-like_N.
DR InterPro; IPR042097; Aminopeptidase_N-like_N_sf.
DR InterPro; IPR038438; PepN_Ig-like_sf.
DR InterPro; IPR014782; Peptidase_M1_dom.
DR InterPro; IPR012779; Peptidase_M1_pepN.
DR InterPro; IPR024601; Peptidase_M1_pepN_C.
DR InterPro; IPR037144; Peptidase_M1_pepN_C_sf.
DR InterPro; IPR035414; Peptidase_M1_pepN_Ig-like.
DR InterPro; IPR027268; Peptidase_M4/M1_CTD_sf.
DR PANTHER; PTHR46322; PUROMYCIN-SENSITIVE AMINOPEPTIDASE; 1.
DR PANTHER; PTHR46322:SF1; PUROMYCIN-SENSITIVE AMINOPEPTIDASE; 1.
DR Pfam; PF11940; DUF3458; 1.
DR Pfam; PF17432; DUF3458_C; 1.
DR Pfam; PF01433; Peptidase_M1; 1.
DR Pfam; PF17900; Peptidase_M1_N; 1.
DR SUPFAM; SSF63737; Leukotriene A4 hydrolase N-terminal domain; 1.
DR SUPFAM; SSF55486; Metalloproteases ('zincins'), catalytic domain; 1.
PE 4: Predicted;
KW Aminopeptidase {ECO:0000313|EMBL:AKB24515.1};
KW Hydrolase {ECO:0000313|EMBL:AKB24515.1};
KW Protease {ECO:0000313|EMBL:AKB24515.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000033049}.
FT DOMAIN 36..198
FT /note="Aminopeptidase N-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF17900"
FT DOMAIN 336..535
FT /note="Peptidase M1 membrane alanine aminopeptidase"
FT /evidence="ECO:0000259|Pfam:PF01433"
FT DOMAIN 542..627
FT /note="Peptidase M1 alanyl aminopeptidase Ig-like fold"
FT /evidence="ECO:0000259|Pfam:PF11940"
FT DOMAIN 632..934
FT /note="Peptidase M1 alanyl aminopeptidase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF17432"
FT REGION 291..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 979 AA; 110979 MW; 5C34F76D69A5F35D CRC64;
MKPRLYKYYP EDFGELKVDV LHMDLVFDVF DDRTNVKSML RVKTLGEPVE KLELNCRDLE
VRAVSCIQYE VHYKYRKADA ILEVNFLDPV PPETEITVVT DTVCRPTKNI LEGLYYDETP
AGAPPQQITQ CQQWGFQRIV PCIDDMCAKC TYRTTIIADS RYTNLITNGD VVEERHTVKP
GRDKIVYDNS VTPMATYLFF LGVGTYSTFR LEFEYPDGDS FMLELLVPPE SEDGPAGRAL
DILYDSVMWV YLFTGPEQYD PEKLAVRQKL WELVRQRDRL KYGAGAWASK GAGEAEEATE
APEATEATEA PEPAVQKLGK IRAELAKLVG SISPGYKYTG TVYREIGMQN SDFGGMENVG
NTTITTNRIM PFTQITDPAF EYMIRVKVHE YYHNQNGSEV TGKSPFEIWL NEAVTVNVEE
QYHAFLFGEE YQRLGRVLDL LAPGYGTFAL DSGAASMPII PDGFNDPNDL ITAVTYVKAP
EFVRMVETLI GKETFIRGLD NYFKKFGHSN ASTGDWIEAM EEASGQPLKE MAEVWLKQTK
FPVVDVTTEY DEASQNFTFR LNQRVPEGGK PWDFPFRAAL VDEKGNDLAE VLERVSGKQA
EITVENVAKP AFLSLNRDYS FYGKLVYDAS PEELLLQVRK DSDIIGRFTA FYTLVDREKL
RLLKDPEAKP TEDFVSLYYK LLNDRELLEK AGGQFLAIFE SVEEEEYAHR YQALYEVKQK
LLRAVAAKYS NSLLSAYRYF EEASAAKGET LKEEARVIKN RQAKNVCLGI LASLDTPEVH
GLIKQQFEAA SCASDRLSAF AAYLDSSAPD KVDILRAFEA ESKHNLVAWE AFLGVIARSS
SADAVELVRE MEKSEAFRIE QANDQRALYA NFARNRKKSL QTEEGRRFMA EALRKLAPVN
EYSTVHMLNT FADIDMMEKE YRLPLAKLLA DLLADLDPEK VPSVYNRARK LLLGNSRSLG
EYESEYGKNP ALGPEKQKK
//
