ID A0A0E3NY04_9EURY Unreviewed; 292 AA.
AC A0A0E3NY04;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 24-JAN-2024, entry version 30.
DE SubName: Full=5,10-methylenetetrahydrofolate reductase {ECO:0000313|EMBL:AKB25825.1};
DE EC=1.5.1.20 {ECO:0000313|EMBL:AKB25825.1};
GN ORFNames=MSMTP_2356 {ECO:0000313|EMBL:AKB25825.1};
OS Methanosarcina sp. MTP4.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=1434100 {ECO:0000313|EMBL:AKB25825.1, ECO:0000313|Proteomes:UP000033049};
RN [1] {ECO:0000313|EMBL:AKB25825.1, ECO:0000313|Proteomes:UP000033049}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MTP4 {ECO:0000313|EMBL:AKB25825.1,
RC ECO:0000313|Proteomes:UP000033049};
RA Henriksen J.R., Luke J., Reinhart S., Benedict M.N., Youngblut N.D.,
RA Metcalf M.E., Whitaker R.J., Metcalf W.W.;
RT "Methanogenic archaea and the global carbon cycle.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC {ECO:0000256|ARBA:ARBA00004777}.
CC -!- SIMILARITY: Belongs to the methylenetetrahydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00006743}.
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DR EMBL; CP009505; AKB25825.1; -; Genomic_DNA.
DR RefSeq; WP_048180098.1; NZ_CP009505.1.
DR AlphaFoldDB; A0A0E3NY04; -.
DR STRING; 1434100.MSMTP_2356; -.
DR GeneID; 24857749; -.
DR KEGG; metm:MSMTP_2356; -.
DR PATRIC; fig|1434100.4.peg.3144; -.
DR HOGENOM; CLU_057297_2_0_2; -.
DR OrthoDB; 146284at2157; -.
DR UniPathway; UPA00193; -.
DR Proteomes; UP000033049; Chromosome.
DR GO; GO:0004489; F:methylenetetrahydrofolate reductase (NAD(P)H) activity; IEA:UniProtKB-EC.
DR GO; GO:0006555; P:methionine metabolic process; IEA:InterPro.
DR GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR CDD; cd00537; MTHFR; 1.
DR Gene3D; 3.20.20.220; -; 1.
DR InterPro; IPR029041; FAD-linked_oxidoreductase-like.
DR InterPro; IPR003171; Mehydrof_redctse-like.
DR PANTHER; PTHR45754; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR45754:SF3; METHYLENETETRAHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF02219; MTHFR; 1.
DR SUPFAM; SSF51730; FAD-linked oxidoreductase; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|ARBA:ARBA00022827};
KW Flavoprotein {ECO:0000256|ARBA:ARBA00022630};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW ECO:0000313|EMBL:AKB25825.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000033049}.
SQ SEQUENCE 292 AA; 31843 MW; 7441BB85B8FD7679 CRC64;
MLFNFREKLN SSKFLVTAEI SPPKGTNVAA PLEDASQLKG LADALNVTDN QCSIMHMSSL
AFSKLLLDEG HEVIMQLTCR DRNRIGLQSD LLGAYALGLR NVCVMTGDFP SCGDHPGSKP
VYDLDSVQLL ELVRKLDKGI DLAGNRLDGG TSFCMGAVSG INPQEVLQLI KLEKKVSCGA
DFIQTQAVYD VGMFEEFVES TAHLEVPILA GLIPLKSLRM AEYMNEHISG IHVPEEILSR
LKTASDPADE GFSIASETIK ELTKLCRGVH IMPIGSHKNT RRLLSMAGIS RK
//
