ID   A0A0E3S184_9EURY        Unreviewed;       353 AA.
AC   A0A0E3S184;
DT   24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT   24-JUN-2015, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Threonine dehydrogenase and related Zn-dependent dehydrogenase {ECO:0000313|EMBL:AKB74469.1};
GN   ORFNames=MSLAZ_1208 {ECO:0000313|EMBL:AKB74469.1};
OS   Methanosarcina lacustris Z-7289.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC   Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=1434111 {ECO:0000313|EMBL:AKB74469.1, ECO:0000313|Proteomes:UP000033072};
RN   [1] {ECO:0000313|EMBL:AKB74469.1, ECO:0000313|Proteomes:UP000033072}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Z-7289 {ECO:0000313|EMBL:AKB74469.1,
RC   ECO:0000313|Proteomes:UP000033072};
RA   Henriksen J.R., Luke J., Reinhart S., Benedict M.N., Youngblut N.D.,
RA   Metcalf M.E., Whitaker R.J., Metcalf W.W.;
RT   "Methanogenic archaea and the global carbon cycle.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947,
CC         ECO:0000256|RuleBase:RU361277};
CC   -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC       family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
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DR   EMBL; CP009515; AKB74469.1; -; Genomic_DNA.
DR   RefSeq; WP_048125376.1; NZ_CP009515.1.
DR   AlphaFoldDB; A0A0E3S184; -.
DR   STRING; 1434111.MSLAZ_1208; -.
DR   GeneID; 24805936; -.
DR   KEGG; mls:MSLAZ_1208; -.
DR   PATRIC; fig|1434111.4.peg.1562; -.
DR   HOGENOM; CLU_026673_11_3_2; -.
DR   OrthoDB; 9358at2157; -.
DR   Proteomes; UP000033072; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd08285; NADP_ADH; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR42813:SF4; NADP-DEPENDENT ISOPROPANOL DEHYDROGENASE; 1.
DR   PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|RuleBase:RU361277};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Zinc {ECO:0000256|RuleBase:RU361277}.
FT   DOMAIN          10..350
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
SQ   SEQUENCE   353 AA;  37804 MW;  774AE0C8E4872156 CRC64;
     MKGFAMLEIG KVGWIDTERP SAGPYDAIVR PLAVAPCTSD IHTVWEGALG DRKNMVLGHE
     AVGVIEEIGS EVKDFKPGDK VIVPAITPDW RSMEAQDGMP MHSNGMLSGW KFSNFKSGVF
     AEFFHVNDAD MNLALLPKGM PLEQAVMLSD MATTGIQGAE MANIKTGSTV AVIGIGPVGL
     MAVAGASILG AGRLIAIGSR KVCVDLALEY GASEIVDYRK GGLVEQVLEK TKGKGVDSVI
     IAGGDKNTIS DAVKIVKPGG TVSNVNYYGT GDTLPIPRIE WGSGMSHKDI RGGLTTGGRL
     RMERMADLCT YGRIKPEKMV THVFEGFDKM EEALILMKEK PRDLIKPVVL LDE
//