ID A0A0E3S494_9EURY Unreviewed; 331 AA.
AC A0A0E3S494;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE SubName: Full=Cobalt-zinc-cadmium resistance protein {ECO:0000313|EMBL:AKB73608.1};
GN ORFNames=MSLAZ_0347 {ECO:0000313|EMBL:AKB73608.1};
OS Methanosarcina lacustris Z-7289.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=1434111 {ECO:0000313|EMBL:AKB73608.1, ECO:0000313|Proteomes:UP000033072};
RN [1] {ECO:0000313|EMBL:AKB73608.1, ECO:0000313|Proteomes:UP000033072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Z-7289 {ECO:0000313|EMBL:AKB73608.1,
RC ECO:0000313|Proteomes:UP000033072};
RA Henriksen J.R., Luke J., Reinhart S., Benedict M.N., Youngblut N.D.,
RA Metcalf M.E., Whitaker R.J., Metcalf W.W.;
RT "Methanogenic archaea and the global carbon cycle.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP009515; AKB73608.1; -; Genomic_DNA.
DR RefSeq; WP_048124452.1; NZ_CP009515.1.
DR AlphaFoldDB; A0A0E3S494; -.
DR STRING; 1434111.MSLAZ_0347; -.
DR GeneID; 24805034; -.
DR KEGG; mls:MSLAZ_0347; -.
DR PATRIC; fig|1434111.4.peg.441; -.
DR HOGENOM; CLU_013430_3_6_2; -.
DR OrthoDB; 8907at2157; -.
DR Proteomes; UP000033072; Chromosome.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR Gene3D; 1.20.1510.10; Cation efflux protein transmembrane domain; 1.
DR Gene3D; 3.30.70.1350; Cation efflux protein, cytoplasmic domain; 1.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR027470; Cation_efflux_CTD.
DR InterPro; IPR036837; Cation_efflux_CTD_sf.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR NCBIfam; TIGR01297; CDF; 1.
DR PANTHER; PTHR43840; MITOCHONDRIAL METAL TRANSPORTER 1-RELATED; 1.
DR PANTHER; PTHR43840:SF15; MITOCHONDRIAL METAL TRANSPORTER 1-RELATED; 1.
DR Pfam; PF01545; Cation_efflux; 1.
DR Pfam; PF16916; ZT_dimer; 1.
DR SUPFAM; SSF160240; Cation efflux protein cytoplasmic domain-like; 1.
DR SUPFAM; SSF161111; Cation efflux protein transmembrane domain-like; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 98..117
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 137..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 179..199
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 235..312
FT /note="Cation efflux protein cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF16916"
SQ SEQUENCE 331 AA; 35840 MW; 94FC72FE3FE2DAD3 CRC64;
MKGTDSTGNE TLSHSDETEN TRYSQAIYVT KVAMVSNVLL TGFKFFAGIM GNSSAMIADA
AHSLSDFMTD IAVIAGLKVA RKPGDSTHNY GHGKIETLSA AFIGLVLVAV AFGIFWGGLQ
KVIAFYQGEV LPTPSGIALV AAILSIVIKE WLYRYTIIYA RKLKSDALIA NAWHHRSDAF
SSVGTMVGIG GAILLGGRWV VLDPIAAVIL SFFIFKVAFD ISYKNLNELL EASLDSATHR
SIEETLMSTK GVLGFHELKT RKIGNAMAAD VHIEVDRNLN IVDAHEISTQ VEDRLKEVCG
KNGYFSIHVE PCSDSNSDSG YKGKNKDHTS S
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