ID A0A0E3S659_9EURY Unreviewed; 612 AA.
AC A0A0E3S659;
DT 24-JUN-2015, integrated into UniProtKB/TrEMBL.
DT 24-JUN-2015, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE SubName: Full=Trk system potassium uptake protein TrkA {ECO:0000313|EMBL:AKB74458.1};
GN ORFNames=MSLAZ_1197 {ECO:0000313|EMBL:AKB74458.1};
OS Methanosarcina lacustris Z-7289.
OC Archaea; Euryarchaeota; Stenosarchaea group; Methanomicrobia;
OC Methanosarcinales; Methanosarcinaceae; Methanosarcina.
OX NCBI_TaxID=1434111 {ECO:0000313|EMBL:AKB74458.1, ECO:0000313|Proteomes:UP000033072};
RN [1] {ECO:0000313|EMBL:AKB74458.1, ECO:0000313|Proteomes:UP000033072}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Z-7289 {ECO:0000313|EMBL:AKB74458.1,
RC ECO:0000313|Proteomes:UP000033072};
RA Henriksen J.R., Luke J., Reinhart S., Benedict M.N., Youngblut N.D.,
RA Metcalf M.E., Whitaker R.J., Metcalf W.W.;
RT "Methanogenic archaea and the global carbon cycle.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Part of a potassium transport system.
CC {ECO:0000256|ARBA:ARBA00003660}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; CP009515; AKB74458.1; -; Genomic_DNA.
DR RefSeq; WP_048125368.1; NZ_CP009515.1.
DR AlphaFoldDB; A0A0E3S659; -.
DR STRING; 1434111.MSLAZ_1197; -.
DR GeneID; 24805923; -.
DR KEGG; mls:MSLAZ_1197; -.
DR PATRIC; fig|1434111.4.peg.1541; -.
DR HOGENOM; CLU_005912_10_1_2; -.
DR OrthoDB; 11709at2157; -.
DR Proteomes; UP000033072; Chromosome.
DR GO; GO:0005886; C:plasma membrane; IEA:InterPro.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0015079; F:potassium ion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.30.70.1450; Regulator of K+ conductance, C-terminal domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR006036; K_uptake_TrkA.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR006037; RCK_C.
DR InterPro; IPR036721; RCK_C_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR32507; NA(+)/H(+) ANTIPORTER 1; 1.
DR PANTHER; PTHR32507:SF0; NA(+)_H(+) ANTIPORTER 2-RELATED; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02080; TrkA_C; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR PRINTS; PR00335; KUPTAKETRKA.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR SUPFAM; SSF116726; TrkA C-terminal domain-like; 1.
DR PROSITE; PS51202; RCK_C; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 59..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 91..114
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 120..140
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 152..172
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 184..209
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 221..239
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..262
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..291
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..320
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 332..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 365..384
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 398..520
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
FT DOMAIN 530..612
FT /note="RCK C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51202"
SQ SEQUENCE 612 AA; 66137 MW; 9582FBB36022584D CRC64;
MLDPILLLGL VVAVLIMSLV AQALSCYFRI PFIIFLLIEG IIVGPEVLNL LDPALYSEGL
SAIVAISISV IVFDGGLHID LKHIRMVQDS VLKLTTIGVF VTFLGTTVLT NLLIGIPIEL
AALFGALVTA TGPTVITPIL RNIHISHRLG KILELEGVLN DAASVILAAM VFEWVAAELS
GIDAVIFILY RLGIGIVLGS LSGFALRWFY TRGTAISNRT ARLVSLTAVF ACFVLSEYLG
NESGILAVAV FGIILGTSEF PYKDTIKEFK SDIVIVMLSL IFILLAAMLK FEDIQRIGVS
GIVLVLLLIF LIRPVAVFVS MWNSQISRNE KLFISFVGPR GVVPTSVATY FAIKLDSMGI
PGGQTLVGLV FLTVIITVFM SGSLSKKVAE MLEVIPMEIL IIGGGKVGRI LAERFDKRGE
NVVVVDISEA NCKKCMELGI RIVQGDGGDV NILKKAGIEN AKYVVATTNQ DNTNLLFCQI
AKASFGFRGD QLVARVNEIE NLQAFWNLGI RAMSPATTTA VVLDNMIGRP HLFSMCEVGG
EGDMMEIKVT NPRVIGKAIK DIQFPEKSLL IMVQRGNESI IASGSLVLEY EDIVTVIGEG
DAAKQTADIL FK
//
